Publications

  1. Dalhus B, Nilsen L, Korvald H, Huffman J, Forstrom RJ, McMurray CT, Alseth I, Tainer JA, Bjoras M. Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2. Structure. 2013 Jan 8; 21(1):154-66. Epub 2012 Dec 13.
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  2. Xun Z, Lee DY, Lim J, Canaria CA, Barnebey A, Yanonne SM, McMurray CT. Retinoic acid-induced differentiation increases the rate of oxygen consumption and enhances the spare respiratory capacity of mitochondria in SH-SY5Y cells. Mech Ageing Dev. 2012 Apr; 133(4):176-85. Epub 2012 Feb 08.
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  3. Majka J, Alford B, Ausio J, Finn RM, McMurray CT. ATP hydrolysis by RAD50 protein switches MRE11 enzyme from endonuclease to exonuclease. J Biol Chem. 2012 Jan 20; 287(4):2328-41. Epub 2011 Nov 18.
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  4. Lee DY, Platt V, Bowen B, Louie K, Canaria CA, McMurray CT, Northen T. Resolving brain regions using nanostructure initiator mass spectrometry imaging of phospholipids. Integrative Biology. 2012; 4(6):693-9.
  5. Lang WH, Coats JE, Majka J, Hura GL, Lin YY, Rasnik I, McMurray CT. Conformational trapping of Mismatch Recognition Complex MSH2/MSH3 on repair-resistant DNA loops. Proceedings Of The National Academy Of Sciences Of The United States Of. 2011 Oct 18; 108(42):E837-44.
  6. Kovtun IV, Johnson KO, McMurray CT. Cockayne syndrome B protein antagonizes OGG1 in modulating CAG repeat length in vivo. Aging (Albany NY). 2011 May; 3(5):509-14.
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  7. McMurray CT. Mechanisms of trinucleotide repeat instability during human development. Nat Rev Genet. 2010 Nov; 11(11):786-99.
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  8. Liu Y, Prasad R, Beard WA, Hou EW, Horton JK, McMurray CT, Wilson SH. Coordination between polymerase beta and FEN1 can modulate CAG repeat expansion. J Biol Chem. 2009 Oct 9; 284(41):28352-66. Epub 2009 Aug 11.
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  9. Trushina E, Rana S, McMurray CT, Hua DH. Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons. BMC Neurosci. 2009 Jul; 10.
  10. Owen BA, H Lang W, McMurray CT. The nucleotide binding dynamics of human MSH2-MSH3 are lesion dependent. Nat Struct Mol Biol. 2009 May; 16(5):550-7. Epub 2009 Apr 19.
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  11. Koti JS, Morais MC, Rajagopal R, Owen BA, McMurray CT, Anderson DL. DNA packaging motor assembly intermediate of bacteriophage phi29. J Mol Biol. 2008 Sep 19; 381(5):1114-32. Epub 2008 Apr 20.
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  12. Rolseth V, Runden-Pran E, Luna L, McMurray C, Bjoras M, Ottersen OP. Widespread distribution of DNA glycosylases removing oxidative DNA lesions in human and rodent brains. DNA Repair (Amst) 2008 Sep 1; 7(9):1578-88. Epub 2008 Jul 22.
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  13. McMurray CT. Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease. DNA Repair (Amst). 2008 Jul 1; 7(7):1121-34. Epub 2008 May 09.
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  14. Delagoutte E, Goellner GM, Guo J, Baldacci G, McMurray CT. Single-stranded DNA-binding protein in vitro eliminates the orientation-dependent impediment to polymerase passage on CAG/CTG repeats. J Biol Chem. 2008 May 9; 283(19):13341-56. Epub 2008 Feb 08.
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  15. Kovtun IV, McMurray CT. Features of trinucleotide repeat instability in vivo. Cell Res. 2008 Jan; 18(1):198-213.
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  16. Kovtun IV, Liu Y, Bjoras M, Klungland A, Wilson SH, McMurray CT. OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature. 2007 May 24; 447(7143):447-52. Epub 2007 Apr 22.
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  17. Trushina E, McMurray CT. Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases. Neuroscience. 2007 Apr 14; 145(4):1233-48. Epub 2007 Feb 14.
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  18. Kovtun IV, McMurray CT. Crosstalk of DNA glycosylases with pathways other than base excision repair. DNA Repair (Amst) 2007 Apr 1; 6(4):517-29.
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  19. Trushina E, Singh RD, Dyer RB, Cao S, Shah VH, Parton RG, Pagano RE, McMurray CT. Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo. Hum Mol Genet. 2006 Dec 15; 15(24):3578-91.
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  20. Trushina E, Du Charme J, Parisi J, McMurray CT. Neurological abnormalities in caveolin-1 knock out mice. Behav Brain Res. 2006 Sep 15; 172(1):24-32. Epub 2006 Jun 05.
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  21. McMurray CT. To die or not to die: DNA repair in neurons. Mutat Res. 2005 Sep 4; 577(1-2):260-74.
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  22. Owen BAL, Yang ZY, Lai MY, Gajek M, Badger JD, Hayes JJ, Edelmann W, Kucherlapati R, Wilson TM, McMurray CT. (CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition. Nat Struct Mol Biol. 2005 Aug; 12(8):663-70.
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  23. Kantarci OH, Goris A, Hebrink DD, Heggarty S, Cunningham S, Alloza I, Atkinson EJ, de Andrade M, McMurray CT, Graham CA, Hawkins SA, Billiau A, Dubois B, Weinshenker BG, Vandenbroeck K. IFNG polymorphisms are associated with gender differences in susceptibility to multiple sclerosis. Genes Immun. 2005 Mar; 6(2):153-61.
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  24. Ortiz M, Sanoguel Z, Hu HT, Chazin WJ, McMurray C, Salisbury JL, Pastrana-Rios B. Dynamics of hydrogen - Deuterium exchange in Chlamydomonas centrin. Biochemistry. 2005 Feb 22; 44(7):2409-18.
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  25. Eide L, McMurray CT. Culture of adult mouse neurons. Biotechniques. 2005 Jan; 38(1):99-104.
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  26. Trushina E, Dyer RB, Badger JD 2nd, Ure D, Eide L, Tran DD, Vrieze BT, Legendre-Guillemin V, McPherson PS, Mandavilli BS, Van Houten B, Zeitlin S, McNiven M, Aebersold R, Hayden M, Parisi JE, Seeberg E, Dragatsis I, Doyle K, Bender A, Chacko C, McMurray Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro. Mol Cell Biol. 2004 Sep; 24(18):8195-209.
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  27. Kantarci OH, Hebrink DD, Achenbach SJ, Pittock SJ, Altintas A, Schaefer-Klein JL, Atkinson EJ, de Andrade M, McMurray CT, Rodriguez M, Weinshenker BG. Association of APOE polymorphisms with disease severity in MS is limited to women. Neurology. 2004 Mar 9; 62(5):811-4.
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  28. Kovtun IV, Welch G, Guthrie HD, Hafner KL, McMurray CT. CAG repeat lengths in X- and Y-bearing sperm indicate that gender bias during transmission of Huntington's disease gene is determined in the embryo. J Biol Chem. 2004 Mar 5; 279(10):9389-91.
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  29. Kantarci OH, Hebrink DD, Achenbach SJ, Atkinson EJ, de Andrade M, McMurray CT, Weinshenker BG. CD95 polymorphisms are associated with susceptibility to MS in women. A population-based study of CD95 and CD95L in MS. J Neuroimmunol. 2004 Jan; 146(1-2):162-70.
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  30. Trushina E, Heldebrant MP, Perez-Terzic CM, Bortolon R, Kovtun IV, Badger JD 2nd, Terzic A, Estevez A, Windebank AJ, Dyer RB, Yao J, McMurray CT. Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12171-6. Epub 2003 Oct 03.
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  31. Spiro C, McMurray CT. Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability. Mol Cell Biol. 2003 Sep; 23(17):6063-74.
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  32. Morais MC, Kanamaru S, Badasso MO, Koti JS, Owen BAL, McMurray CT, Anderson DL, Rossmann MG. Bacteriophage phi 29 scaffolding protein gp7 before and after prohead assembly. Nat Struct Biol. 2003 Jul; 10(7):572-6.
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  33. McMurray CT, Kortun IV. Repair in haploid male germ cells occurs late in differentiation as chromatin is condensing. Chromosoma. 2003 May; 111(8):505-8.
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  34. Kantarci OH, Schaefer-Klein JL, Hebrink DD, Achenbach SJ, Atkinson EJ, McMurray CT, Weinshenker BG. A population-based study of IL4 polymorphisms in multiple sclerosis. J Neuroimmunol. 2003 Apr; 137(1-2):134-9.
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  35. Johnson-Pais TL, Singer FR, Bone HG, McMurray CT, Hansen MF, Leach RJ. Identification of a novel tandem duplication in Exon 1 of the TNFRSF11A gene in two unrelated patients with familial expansile osteolysis. J Bone Miner Res. 2003 Feb; 18(2):376-80.
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  36. Kantarci OH, Hebrink DD, Achenbach SJ, Atkinson EJ, Waliszewska A, Buckle G, McMurray CT, de Andrade M, Hafler DA, Weinshenker BG. CTLA4 is associated with susceptibility to multiple sclerosis. J Neuroimmunol. 2003 Jan; 134(1-2):133-41.
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  37. Sobell JL, Mikesell MJ, McMurray CT. Genetics and etiopathophysiology of schizophrenia. Mayo Clin Proc. 2002 Oct; 77(10):1068-82.
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  38. Hopfner KP, Craig L, Moncalian G, Zinkel RA, Usui T, Owen BA, Karcher A, Henderson B, Bodmer JL, McMurray CT, Carney JP, Petrini JHJ, Tainer JA. The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature. 2002 Aug 1; 418(6897):562-6.
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  39. Kantarci OH, Lesnick TG, Yang P, Meyer RL, Hebrink DD, McMurray CT, Weinshenker BG. Myeloperoxidase -463 (G-->A) polymorphism associated with lower risk of lung cancer. Mayo Clin Proc. 2002 Jan; 77(1):17-22.
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  40. McMurray CT. Expanding horizons for treatment. Lancet. 2001 Dec; (Suppl S):S37.
  41. McMurray SE, McMurray CT. A sports star and a cook. Lancet. 2001 Dec; (Suppl S):S38.
  42. McMurray CT. Huntington's disease. Expanding horizons for treatment. Lancet. 2001 Dec; 358 Suppl:S37.
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  43. Weinshenker BG, Hebrink D, Kantarci OH, Schaefer-Klein J, Atkinson E, Schaid D, McMurray CM. Genetic variation in the transforming growth factor beta1 gene in multiple sclerosis. J Neuroimmunol. 2001 Nov 1; 120(1-2):138-45.
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  44. McMurray CT. Huntington's disease: new hope for therapeutics. Trends Neurosci. 2001 Nov; 24(11 Suppl):S32-8.
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  45. Dyer RB, McMurray CT. Mutant protein in Huntington disease is resistant to proteolysis in affected brain. Nat Genet. 2001 Nov; 29(3):270-8.
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  46. Kovtun IV, McMurray CT. Trinucleotide expansion in haploid germ cells by gap repair. Nat Genet. 2001 Apr; 27(4):407-11.
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  47. Wu X, McMurray CT. Calmodulin kinase II attenuation of gene transcription by preventing cAMP response element-binding protein (CREB) dimerization and binding of the CREB-binding protein. J Biol Chem. 2001 Jan 19; 276(3):1735-41. Epub 2000 Sep 29.
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  48. Kovtun IV, Goellner G, McMurray CT. Structural features of trinucleotide repeats associated with DNA expansion. Biochem Cell Biol. 2001; 79(3):325-36.
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  49. Kovtun IV, Therneau TM, McMurray CT. Gender of the embryo contributes to CAG instability in transgenic mice containing a Huntington's disease gene. Hum Mol Genet. 2000 Nov 1; 9(18):2767-75.
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  50. Raca G, Siyanova EY, McMurray CT, Mirkin SM. Expansion of the (CTG)(n) repeat in the 5'-UTR of a reporter gene impedes translation. Nucleic Acids Res. 2000 Oct 15; 28(20):3943-9.
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  51. McMurray CT. Neurodegeneration: diseases of the cytoskeleton? Cell Death & Differentiation. 2000 Oct; 7(10):861-5.
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  52. Kantarci OH, Atkinson EJ, Hebrink DD, McMurray CT, Weinshenker BG. Association of two variants in IL-1beta and IL-1 receptor antagonist genes with multiple sclerosis. J Neuroimmunol. 2000 Jul 1; 106(1-2):220-7.
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  53. Weinshenker BG, Hebrink DD, Klein C, Atkinson EJ, O'Brien PC, McMurray CT. Genetic variation in the B7-1 gene in patients with multiple sclerosis. J Neuroimmunol. 2000 Jun 26; 105(2):184-8.
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  54. Kantarci OH, Atkinson EJ, Hebrink DD, McMurray CT, Weinshenker BG. Association of a myeloperoxidase promoter polymorphism with multiple sclerosis. J Neuroimmunol. 2000 Jun 26; 105(2):189-94.
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  55. Richard GF, Goellner GM, McMurray CT, Haber JE. Recombination-induced CAG trinucleotide repeat expansions in yeast involve the MRE11-RAD50-XRS2 complex. EMBO J. 2000 May 15; 19(10):2381-90.
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  56. Hoyne PR, Gacy AM, McMurray CT, Maher LJ 3rd. Stabilities of intrastrand pyrimidine motif DNA and RNA triple helices. Nucleic Acids Res. 2000 Feb 1; 28(3):770-5.
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  57. Trushina YV, McMurray CT. Measurement of nitrosothiols in biological samples for automated analysis. Recent Research Developments in Analytical Chemistry. 2000; 1:1-20.
  58. Trushina EV, Oda RP, McMurray CT, Landers JP. Effective and reproducible capillary electrophoretic separation of thiols under conditions where exceptionally high current is generated. Anal Chem. 1999 Dec 15; 71(24):5569-73.
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  59. Spiro C, Pelletier R, Rolfsmeier ML, Dixon MJ, Lahue RS, Gupta G, Park MS, Chen X, Mariappan SV, McMurray CT. Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats. Mol Cell. 1999 Dec; 4(6):1079-85.
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  60. Hopkins HP, Hamilton DD, Wilson WD, McMurray CT. Calorimetric studies on the pH dependence in hairpin formation within the human enkephalin enhancer region. J Solution Chem. 1999 Jun; 28(6):759-768.
  61. Weinshenker BG, Hebrink D, Wingerchuk DM, Klein CJ, Atkinson E, O'Brien PC, McMurray CT. Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS. Neurology. 1999 Apr 22; 52(7):1500-3.
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  62. McMurray CT. DNA secondary structure: a common and causative factor for expansion in human disease. Proc Natl Acad Sci U S A. 1999 Mar 2; 96(5):1823-5.
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  63. Wu X, Spiro C, Owen WG, McMurray CT. cAMP response element-binding protein monomers cooperatively assemble to form dimers on DNA. J Biol Chem. 1998 Aug 14; 273(33):20820-7.
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  64. Spiro C, McMurray CT. Regulation of the proenkephalin enhancer and synthesis by conformational switching: implications for decoy design. Antisense & Nucleic Acid Drug Development. 1998 8:159-165.
  65. Zhang F, Lemieux S, Wu X, St-Arnaud D, McMurray CT, Major F, Anderson D. Function of hexameric RNA in packaging of bacteriophage phi 29 DNA in vitro. Mol Cell. 1998 Jul; 2(1):141-7.
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  66. Weinshenker BG, Hebrink DD, Gacy AM, McMurray CT. DNA compression caused by an upstream point mutation. Biotechniques. 1998 Jul; 25(1):68-72.
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  67. Gacy AM, McMurray CT. Influence of hairpins on template reannealing at trinucleotide repeat duplexes: a model for slipped DNA. Biochemistry. 1998 Jun 30; 37(26):9426-34.
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  68. Spiro C, McMurray CT. Transcriptional regulation of the human proenkephalin gene by conformational switching: implications for decoy design. Antisense & Nucleic Acid Drug Development. 1998 Apr; 8(2):159-65.
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  69. Gacy AM, Goellner GM, Spiro C, Chen X, Gupta G, Bradbury EM, Dyer RB, Mikesell MJ, Yao JZ, Johnson AJ, Richter A, Melancon SB, McMurray CT. GAA instability in Friedreich's Ataxia shares a common, DNA-directed and intraallelic mechanism with other trinucleotide diseases. Mol Cell. 1998 Mar; 1(4):583-93.
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  70. Zhang F, Lemieux S, Wu X, McMurray CT, Major F, Anderson D, McMurray CT. Function of hexameric RNA in packaging of bacteriophage PHI29 DNA in vitro. Chemtracts. 1998; 11(13):994-999.
  71. McMurray CT. Commentary on Function of Hexameric RNA in Packaging of Bacteriophage p29 DNA in Vitro. Biochemistry and Molecular Biology (Special Issue "Biological Application of the Analytical Ultracentrifuge" Chemtracts) 1998; 11(13):994-9.
  72. Spiro C, McMurray CT. Switching of DNA secondary structure in proenkephalin transcriptional regulation. J Biol Chem. 1997 Dec 26; 272(52):33145-52.
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  73. Trushina EV, Oda RP, Landers JP, McMurray CT. Determination of nitrite and nitrate reduction by capillary ion electrophoresis. Electrophoresis. 1997 Sep; 18(10):1890-8.
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  74. Mikesell MJ, Barron YD, Nimgaonkar VL, Sobell JL, Sommer SS, McMurray CT. Gly(247)-->Asp proenkephalin A mutation is rare in schizophrenia populations. Am J Med Genet. 1997 Apr 18; 74(2):213-5.
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  75. Goellner GM, Tester D, Thibodeau S, Almqvist E, Goldberg YP, Hayden MR, McMurray CT. Different mechanisms underlie DNA instability in Huntington disease and colorectal cancer. Am J Hum Genet. 1997 Apr; 60(4):879-90.
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  76. Weinshenker BG, Hebrink D, Wingerchuk DM, Sommer SS, McMurray CT. Application of VAPSE-based analysis to genetic studies in MS. Mult Scler. 1997; 3:322.
  77. Mikesell MJ, Sobell JL, Sommer SS, McMurray CT. Identification of a missense mutation and several polymorphisms in the proenkephalin A gene of schizophrenic patients. Am J Med Genet. 1996 Sep 20; 67(5):459-67.
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  78. Spiro C, Bazett-Jones DP, Wu X, McMurray CT. DNA structure determines protein binding and transcriptional efficiency of the proenkephalin cAMP-responsive enhancer. J Biol Chem. 1995 Nov 17; 270(46):27702-10.
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  79. McMurray CT. Mechanisms of DNA expansion. Chromosoma. 1995 Oct; 104(1):2-13.
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  80. Goldberg YP, McMurray CT, Zeisler J, Almqvist E, Sillence D, Richards F, Gacy AM, Buchanan J, Telenius H, Hayden MR. Increased instability of intermediate alleles in families with sporadic Huntington disease compared to similar sized intermediate alleles in the general population. Hum Mol Genet. 1995 Oct; 4(10):1911-8.
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  81. Gacy AM, Goellner G, Juranic N, Macura S, McMurray CT. Trinucleotide repeats that expand in human disease form hairpin structures in vitro. Cell. 1995 May 19; 81(4):533-40.
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  82. McMurray CT, Juranic N, Chandrasekaran S, Macura S, Li Y, Jones RL, Wilson WD. Hairpin formation within the human enkephalin enhancer region. 2. Structural studies. Biochemistry. 1994 Oct 4; 33(39):11960-70.
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  83. Gacy AM, McMurray CT. Hairpin formation within the human enkephalin enhancer region. 1. Kinetic analysis. Biochemistry. 1994 Oct 4; 33(39):11951-9.
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  84. Collins-Hicok J, Lin L, Spiro C, Laybourn PJ, Tschumper R, Rapacz B, McMurray CT. Induction of the rat prodynorphin gene through Gs-coupled receptors may involve phosphorylation-dependent derepression and activation. Mol Cell Biol. 1994 May; 14(5):2837-48.
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  85. Spiro C, Richards JP, Chandrasekaran S, Brennan RG, McMurray CT. Secondary structure creates mismatched base pairs required for high-affinity binding of cAMP response element-binding protein to the human enkephalin enhancer. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4606-10.
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  86. Kaynard AH, McMurray CT, Douglass J, Curry TE, Melner MH. Regulation of prodynorphin gene expression in the ovary: distal DNA regulatory elements confer gonadotropin regulation of promoter activity. Mol Endocrinol. 1992 Dec; 6(12):2244-56.
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  87. McMurray CT, Pollock KM, Douglass J. Cellular and molecular analysis of opioid peptide gene expression. NIDA Res Monogr. 1992; 126:113-31.
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  88. McMurray CT, Small EW, van Holde KE. Binding of ethidium to the nucleosome core particle. 2. Internal and external binding modes. Biochemistry. 1991 Jun 11; 30(23):5644-52.
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  89. McMurray CT, van Holde KE. Binding of ethidium to the nucleosome core particle. 1. Binding and dissociation reactions. Biochemistry. 1991 Jun 11; 30(23):5631-43.
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  90. McMurray CT, Wilson WD, Douglass JO. Hairpin formation within the enhancer region of the human enkephalin gene. Proc Natl Acad Sci U S A. 1991 Jan 15; 88(2):666-70.
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  91. Kaynard AH, McMurray CT, Douglass JO, Melner MH. FSH and LH stimulation of granulosa cell prodynorphin gene expression is abolished by oversuppression of a non-functional mutant of the RII subunit of protein kinase A in regulation and actions of follicle stimulating hormone. Proceedings of the Serono Symposia. 1991; 309-14.
  92. Douglass JO, Iadarola MJ, Hong JS, Garrett JE, McMurray CT. Transcriptional regulation of the rat prodynorphin gene. NIDA Res Monogr. 1991; 111:133-48.
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  93. Yager TD, McMurray CT, van Holde KE. Salt-Induced Release of DNA from Nucleosome Core Particles. Biochemistry. 1989; 28:2271-81.
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  94. Douglass JD, McMurray CT, Garrett J, Adelman JP, Calavetta L. Molecular characterization of the rat prodynorphin gene. Molecular Endocrinology. 1989; 3(12):2070-8.
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