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Publications - Steven M . Sine, Ph.D.

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  1. Sine SM, Wang HL, Hansen S, Taylor P. On the Origin of Ion Selectivity in the Cys-Loop Receptor Family. J Mol Neurosci 2009 Sep 02. [Epub ahead of print]
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  2. Engel AG, Shen XM, Selcen D, Sine SM. What Have We Learned from the Congenital Myasthenic Syndromes. J Mol Neurosci 2009 Aug 18. [Epub ahead of print]
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  3. Cheng XL, Ivanov I, Wang HL, Sine SM, McCammon JA. Molecular-dynamics simulations of ELIC-a prokaryotic homologue of the nicotinic acetylcholine receptor. Biophys J 2009 Jun 3; 96(11):4502-13.
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  4. Mukhtasimova N, Lee WY, Wang HL, Sine SM. Detection and trapping of intermediate states priming nicotinic receptor channel opening. Nature 2009 May 21; 459(7245):451-4. Epub 2009 Apr 01.
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  5. Rayes D, De Rosa MJ, Sine SM, Bouzat C. Number and locations of agonist binding sites required to activate homomeric cys-loop receptors. J Neurosci 2009 May 6; 29(18):6022-32.
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  6. Wang HL, Toghraee R, Papke D, Cheng XL, McCammon JA, Ravaioli U, Sine SM. Single-channel current through nicotinic receptor produced by closure of binding site C-loop. Biophys J 2009 May 6; 96(9):3582-90.
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  7. Lee WY, Free CR, Sine SM. Binding to gating transduction in nicotinic receptors: Cys-loop energetically couples to pre-M1 and M2-M3 regions. J Neurosci 2009 Mar 11; 29(10):3189-99.
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  8. Wu TY, Smith CM, Sine SM, Levandoski MM. Morantel allosterically enhances channel gating of neuronal nicotinic acetylcholine alpha 3 beta 2 receptors. Mol Pharmacol 2008 Aug; 74(2):466-75. Epub 2008 May 05.
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  9. Lee WY, Free CR, Sine SM. Nicotinic receptor interloop proline anchors beta1-beta2 and Cys loops in coupling agonist binding to channel gating. J Gen Physiol 2008 Aug; 132(2):265-78.
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  10. Bouzat C, Bartos M, Corradi J, Sine SM. The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization. J Neurosci 2008 Jul 30; 28(31):7808-19.
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  11. Shen XM, Fukuda T, Ohno K, Sine SM, Engel AG. Congenital myasthenia-related AChR delta subunit mutation interferes with intersubunit communication essential for channel gating. J Clin Invest 2008 May; 118(5):1867-76.
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  12. Wang HL, Cheng X, Taylor P, McCammon JA, Sine SM. Control of cation permeation through the nicotinic receptor channel. PLoS Comput Biol 2008 Feb; 4(2):e41.
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  13. Sine SM, Gao F, Lee WY, Mukhtasimova N, Wang HL, Engel AG. Recent structural and mechanistic insights into endplate acetylcholine receptors. Ann N Y Acad Sci 2008; 1132:53-60.
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  14. Engel AG, Shen XM, Selcen D, Sine SM. Further observations in congenital myasthenic syndromes. Ann N Y Acad Sci 2008; 1132:104-13.
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  15. Cheng X, Ivanov I, Wang H, Sine SM, McCammon JA. Nanosecond-timescale conformational dynamics of the human alpha7 nicotinic acetylcholine receptor. Biophys J 2007 Oct 15; 93(8):2622-34. Epub 2007 Jun 15.
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  16. Ivanov I, Cheng X, Sine SM, McCammon JA. Barriers to ion translocation in cationic and anionic receptors from the Cys-loop family. J Am Chem Soc 2007 Jul 4; 129(26):8217-24. Epub 2007 Jun 07.
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  17. Mukhtasimova N, Sine SM. An intersubunit trigger of channel gating in the muscle nicotinic receptor. J Neurosci 2007 Apr 11; 27(15):4110-9.
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  18. Gao F, Mer G, Tonelli M, Hansen SB, Burghardt TP, Taylor P, Sine SM. Solution NMR of acetylcholine binding protein reveals agonist-mediated conformational change of the C-loop. Mol Pharmacol 2006 Oct; 70(4):1230-5. Epub 2006 Jul 17.
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  19. Shen XM, Deymeer F, Sine SM, Engel AG. Slow-channel mutation in acetylcholine receptor alphaM4 domain and its efficient knockdown. Ann Neurol 2006 Jul; 60(1):128-36.
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  20. Sine SM, Engel AG. Recent advances in Cys-loop receptor structure and function. Nature 2006 Mar 23; 440(7083):448-55.
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  21. Cheng X, Wang H, Grant B, Sine SM, McCammon JA. Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors. PLoS Computational Biology 2006; 2(9):1173-84.
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  22. Lee WY, Sine SM. Principal pathway coupling agonist binding to channel gating in nicotinic receptors. Nature 2005 Nov 10; 438(7065):243-7.
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  23. Rayes D, Spitzmaul G, Sine SM, Bouzat C. Single-channel kinetic analysis of chimeric alpha 7-5HT(3A) receptors. Mol Pharmacol 2005 Nov; 68(5):1475-83.
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  24. Mukhtasimova N, Free C, Sine SM. Initial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptor. J Gen Physiol 2005 Jul; 126(1):23-39.
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  25. Engel AG, Sine SM. Current understanding of congenital myasthenic syndromes. Curr Opin Pharmacol 2005 Jun; 5(3):308-21.
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  26. Henchman RH, Wang HL, Sine SM, Taylor P, McCammon JA. Ligand-induced conformational change in the alpha 7 nicotinic receptor ligand binding domain. Biophys J 2005 Apr; 88(4):2564-76.
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  27. Gao F, Bren N, Burghardt TP, Hansen S, Henchman RH, Taylor P, McCammon JA, Sine SM. Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence. J Biol Chem 2005 Mar 4; 280(9):8443-51.
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  28. Shen XM, Ohno K, Sine SM, Engel AG. Subunit-specific contribution to agonist binding and channel gating revealed by inherited mutation in muscle acetylcholine receptor M3-M4 linker. Brain 2005 Feb; 128(Part 2):345-55.
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  29. Pennington RA, Gao F, Sine SM, Prince RJ. Structural basis for epibatidine selectivity at desensitized nicotinic receptors. Mol Pharmacol 2005 Jan; 67(1):123-31.
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  30. Ellison M, Gao F, Wang HL, Sine SM, Mclntosh JM, Olivera BM. Alpha-conotoxins ImI and ImII target distinct regions of the human alpha 7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes. Biochemistry 2004 Dec 28; 43(51):16019-26.
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  31. Lee WY, Sine SM. Invariant aspartic acid in muscle nicotinic receptor contributes selectively to the kinetics of agonist binding. J Gen Physiol 2004 Nov; 124(5):555-67.
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  32. Bouzat C, Gumilar F, Spitzmaul G, Wang HL, Rayes D, Hansen SB, Taylor P, Sine SM. Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel. Nature 2004 Aug 19; 430(7002):896-900.
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  33. Sine SM, Wang HL, Gao F. Toward atomic-scale understanding of ligand recognition in the muscle nicotinic receptor. Curr Med Chem 2004 Mar; 11(5):559-67.
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  34. Sine SM, Engel AG, Wang HL, Ohno K. Molecular insights into acetylcholine receptor structure and function revealed by mutations causing congenital myasthenic syndromes. Adv Mol Cell Biol 2004; 32:95-119.
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  35. Henchman RH, Wang HL, Sine SM, Taylor P, McCammon JA. Asymmetric structural motions of the homomeric alpha 7 nicotinic receptor ligand binding domain revealed by molecular dynamics simulation. Biophys J 2003 Nov 1; 85(5):3007-18.
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  36. Sine SM, Wang HL, Ohno K, Shen XM, Lee WY, Engel AG. Mechanistic diversity underlying fast channel congenital myasthenic syndromes. Ann N Y Acad Sci 2003 Sep; 998:128-37.
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  37. Engel AG, Ohno K, Shen XM, Sine SM. Congenital myasthenic syndromes: multiple molecular targets at the neuromuscular junction. Ann N Y Acad Sci 2003 Sep; 998:138-60.
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  38. Wang HL, Gao F, Bren N, Sine SM. Curariform antagonists bind in different orientations to the nicotinic receptor ligand binding domain. J Biol Chem 2003 Aug 22; 278(34):32284-91.
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  39. Gao F, Bren N, Little A, Wang HL, Hansen SB, Talley TT, Taylor P, Sine SM. Curariform antagonists bind in different orientations to acetylcholine-binding protein. J Biol Chem 2003 Jun 20; 278(25):23020-6.
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  40. Engel AG, Ohno K, Sine SM. Congenital myasthenic syndromes: a diverse array of molecular targets. J Neurocytol 2003 Jun-Sep; 32(5-8):1017-37.
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  41. Engel AG, Ohno K, Sine SM. Sleuthing molecular targets for neurological diseases at the neuromuscular junction. Nat Rev Neurosci 2003 May; 4(5):339-52.
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  42. Shen XM, Ohno KJ, Tsujino A, Brengman JM, Gingold M, Sine SM, Engel AG. Mutation causing severe myasthenia reveals functional asymmetry of AChR signature cystine loops in agonist binding and gating. J Clin Invest 2003 Feb; 111(4):497-505.
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  43. Engel AG, Ohno K, Sine SM. Congenital myasthenic syndromes: progress over the past decade. Muscle Nerve 2003 Jan; 27(1):4-25.
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  44. Sine SM. The nicotinic receptor ligand binding domain. J Neurobiol 2002 Dec; 53(4):431-46.
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  45. Engel AG, Ohno K, Sine SM. The spectrum of congenital myasthenic syndromes. Mol Neurobiol 2002 Oct-Dec; 26(2-3):347-67.
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  46. Sine SM, Shen XM, Wang HL, Ohno K, Lee WY, Tsujino A, Brengmann J, Bren N, Vajsar J, Engel AG. Naturally occurring mutations at the acetylcholine receptor binding site independently alter ACh binding and channel gating. J Gen Physiol 2002 Oct; 120(4):483-96.
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  47. Prince RJ, Pennington RA, Sine SM. Mechanism of tacrine block at adult human muscle nicotinic acetylcholine receptors. J Gen Physiol 2002 Sep; 120(3):369-93.
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  48. Sine SM, Wang HL, Bren N. Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain. J Biol Chem 2002 Aug 9; 277(32):29210-23.
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  49. Molles BE, Tsigelny I, Nguyen PD, Gao SX, Sine SM, Taylor P. Residues in the epsilon subunit of the nicotinic acetylcholine receptor interact to confer selectivity of waglerin-1 for the alpha-epsilon subunit interface site. Biochemistry 2002 Jun 25; 41(25):7895-906.
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  50. Bouzat C, Gumilar F, Esandi MD, Sine SM. Subunit-selective contribution to channel gating of the M4 domain of the nicotinic receptor. Biophys J 2002 Apr; 82(4):1920-9.
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  51. Ibanez-Tallon I, Miwa JM, Wang HL, Adams NC, Crabtree GW, Sine SM, Heintz N. Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1. Neuron 2002 Mar 14; 33(6):893-903.
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  52. Molles BE, Rezai P, Kline EF, McArdle JJ, Sine SM, Taylor P. Identification of residues at the alpha and epsilon subunit interfaces mediating species selectivity of Waglerin-1 for nicotinic acetylcholine receptors. J Biol Chem 2002 Feb 15; 277(7):5433-40.
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  53. Malany S, Osaka H, Sine SM, Taylor P. Orientation of alpha-neurotoxin at the subunit interfaces of the nicotinic acetylcholine receptor. Biochemistry 2000 Dec 19; 39(50):15388-98.
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  54. Grosman C, Salamone FN, Sine SM, Auerbach A. The extracellular linker of muscle acetylcholine receptor channels is a gating control element. J Gen Physiol 2000 Sep; 116(3):327-40.
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  55. Wang HL, Ohno K, Milone M, Brengman JM, Evoli A, Batocchi AP, Middleton LT, Christodoulou K, Engel AG, Sine SM. Fundamental gating mechanism of nicotinic receptor channel revealed by mutation causing a congenital myasthenic syndrome. J Gen Physiol 2000 Sep; 116(3):449-62.
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  56. Bouzat C, Barrantes F, Sine S. Nicotinic receptor fourth transmembrane domain: hydrogen bonding by conserved threonine contributes to channel gating kinetics. J Gen Physiol 2000 May; 115(5):663-72.
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  57. Bren N, Sine SM. Hydrophobic pairwise interactions stabilize alpha-conotoxin MI in the muscle acetylcholine receptor binding site. J Biol Chem 2000 Apr 28; 275(17):12692-700.
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  58. Osaka H, Malany S, Molles BE, Sine SM, Taylor P. Pairwise electrostatic interactions between alpha-neurotoxins and gamma, delta, and epsilon subunits of the nicotinic acetylcholine receptor. J Biol Chem 2000 Feb 25; 275(8):5478-84.
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  59. Quiram PA, McIntosh JM, Sine SM. Pairwise interactions between neuronal alpha(7) acetylcholine receptors and alpha-conotoxin PnIB. J Biol Chem 2000 Feb 18; 275(7):4889-96.
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  60. Quiram PA, Ohno K, Milone M, Patterson MC, Pruitt NJ, Brengman JM, Sine SM, Engel AG. Mutation causing congenital myasthenia reveals acetylcholine receptor beta/delta subunit interaction essential for assembly. J Clin Invest 1999 Nov; 104(10):1403-10.
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  61. Prince RJ, Sine SM. Acetylcholine and epibatidine binding to muscle acetylcholine receptors distinguish between concerted and uncoupled models. J Biol Chem 1999 Jul 9; 274(28):19623-9.
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  62. Quiram PA, Jones JJ, Sine SM. Pairwise interactions between neuronal alpha (7) acetylcholine receptors and alpha-conotoxin ImI. J Biol Chem 1999 Jul 9; 274(28):19517-24.
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  63. Osaka H, Malany S, Kanter JR, Sine SM, Taylor P. Subunit interface selectivity of the alpha-neurotoxins for the nicotinic acetylcholine receptor. J Biol Chem 1999 Apr 2; 274(14):9581-6.
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  64. Wang HL, Milone M, Ohno K, Shen XM, Tsujino A, Batocchi AP, Tonali P, Brengman J, Engel AG, Sine SM. Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating. Nat Neurosci 1999 Mar; 2(3):226-33.
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  65. Engel AG, Ohno K, Sine SM. Congenital myasthenic syndromes: recent advances. Arch Neurol 1999 Feb; 56(2):163-7.
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  66. Prince RJ, Sine SM. Epibatidine activates muscle acetylcholine receptors with unique site selectivity. Biophys J 1998 Oct; 75(4):1817-27.
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  67. Engel AG, Ohno K, Milone M, Sine SM. Congenital myasthenic syndromes. New insights from molecular genetic and patch-clamp studies. Ann N Y Acad Sci 1998 May 13; (841):140-56.
  68. Quiram PA, Sine SM. Identification of residues in the neuronal alpha(7) acetylcholine receptor that confer selectivity for conotoxin IMI. J Biol Chem 1998 May 1; 273(18):11001-6.
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  69. Quiram PA, Sine SM. Structural elements in alpha-conotoxin IMI essential for binding to neuronal alpha(7) receptors. J Biol Chem 1998 May 1; 273(18):11007-11.
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  70. Prince RJ, Sine SM. Epibatidine binds with unique site and state selectivity to muscle nicotinic acetylcholine receptors. J Biol Chem 1998 Apr 3; 273(14):7843-9.
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  71. Sugiyama N, Marchot P, Kawanishi C, Osaka H, Molles B, Sine SM, Taylor P. Residues at the subunit interfaces of the nicotinic acetylcholine receptor that contribute to alpha-conotoxin M1 binding. Mol Pharmacol 1998 Apr; 53(4):787-94.
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  72. Taylor P, Osaka H, Molles BE, Sugiyama N, Marchot P, Ackermann EJ, Malany S, McArdle JJ, Sine SM, Tsigelny I. Toxins selective for subunit interfaces as probes of nicotinic acetylcholine receptor structure. J Physiol Paris 1998 Apr; 92(2):79-83.
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  73. Sine SM, Bren N, Quiram PA. Molecular dissection of subunit interfaces in the nicotinic acetylcholine receptor. J Physiol Paris 1998 Apr; 92(2):101-5.
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  74. Engel AG, Ohno K, Sine SM. Congenital myasthenic syndromes: experiments of nature. J Physiol Paris 1998 Apr; 92(2):113-7.
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  75. Milone M, Wang HL, Ohno K, Prince R, Fukudome T, Shen XM, Brengman JM, Griggs RC, Sine SM, Engel AG. Mode switching kinetics produced by a naturally occurring mutation in the cytoplasmic loop of the human acetylcholine receptor epsilon subunit. Neuron 1998 Mar; 20(3):575-88.
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  76. Engel AG, Ohno K, Wang HL, Milone M, Sine SM. Molecular basis of congenital myasthenic syndromes: mutations in the acetylcholine receptor. Neuroscientist 1998; 4(3):185-94.
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  77. Bren N, Sine SM. Identification of residues in the adult nicotinic acetylcholine receptor that confer selectivity for curariform antagonists. J Biol Chem 1997 Dec 5; 272(49):30793-8.
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  78. Sine SM. Identification of equivalent residues in the gamma, delta, and epsilon subunits of the nicotinic receptor that contribute to alpha-bungarotoxin binding. J Biol Chem 1997 Sep 19; 272(38):23521-7.
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  79. Milone M, Wang HL, Ohno K, Fukudome T, Pruitt JN, Bren N, Sine SM, Engel AG. Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit. J Neurosci 1997 Aug 1; 17(15):5651-65.
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  80. Tsigelny I, Sugiyama N, Sine SM, Taylor P. A model of the nicotinic receptor extracellular domain based on sequence identity and residue location. Biophys J 1997 Jul; 73(1):52-66.
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  81. Wang HL, Auerbach A, Bren N, Ohno K, Engel AG, Sine SM. Mutation in the M1 domain of the acetylcholine receptor alpha subunit decreases the rate of agonist dissociation. J Gen Physiol 1997 Jun; 109(6):757-66.
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  82. Ohno K, Quiram PA, Milone M, Wang HL, Harper MC, Pruitt JN 2nd, Brengman JM, Pao L, Fischbeck KH, Crawford TO, Sine SM, Engel AG. Congenital myasthenic syndromes due to heteroallelic nonsense/missense mutations in the acetylcholine receptor epsilon subunit gene: identification and functional characterization of six new mutations. Hum Mol Genet 1997 May; 6(5):753-66.
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  83. Engel AG, Ohno K, Milone M, Sine SM. Congenital myasthenic syndromes caused by mutations in acetylcholine receptor genes. Neurology 1997; 48(4 Suppl 5):S28-35.
  84. Fu DX, Sine SM. Asymmetric contribution of the conserved disulfide loop to subunit oligomerization and assembly of the nicotinic acetylcholine receptor. J Biol Chem 1996 Dec 6; 271(49):31479-84.
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  85. Engel AG, Ohno K, Bouzat C, Sine SM, Griggs RC. End-plate acetylcholine receptor deficiency due to nonsense mutations in the epsilon subunit. Ann Neurol 1996 Nov; 40(5):810-7.
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  86. Prince RJ, Sine SM. Molecular dissection of subunit interfaces in the acetylcholine receptor. Identification of residues that determine agonist selectivity. J Biol Chem 1996 Oct 18; 271(42):25770-7.
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  87. Akk G, Sine S, Auerbach A. Binding sites contribute unequally to the gating of mouse nicotinic alpha D200N acetylcholine receptors. J Physiol (Lond) 1996 Oct 1; 496(Pt 1):185-96.
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  88. Engel AG, Ohno K, Milone M, Wang HL, Nakano S, Bouzat C, Pruitt JN 2nd, Hutchinson DO, Brengman JM, Bren N, Sieb JP, Sine SM. New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome. Hum Mol Genet 1996 Sep; 5(9):1217-27.
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  89. Ohno K, Wang HL, Milone M, Bren N, Brengman JM, Nakano S, Quiram P, Pruitt JN, Sine SM, Engel AG. Congenital myasthenic syndrome caused by decreased agonist binding affinity due to a mutation in the acetylcholine receptor epsilon subunit. Neuron 1996 Jul; 17(1):157-70.
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  90. Chen J, Zhang Y, Akk G, Sine S, Auerbach A. Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating. Biophys J 1995 Sep; 69(3):849-59.
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  91. Sine SM, Ohno K, Bouzat C, Auerbach A, Milone M, Pruitt JN, Engel AG. Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist-binding affinity. Neuron 1995 Jul; 15:229-39.
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  92. Sine SM, Kreienkamp HJ, Bren N, Maeda R, Taylor P. Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of determinants of alpha-conotoxin M1 selectivity. Neuron 1995 Jul; 15(1):205-11.
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  93. Kreienkamp HJ, Maeda RK, Sine SM, Taylor P. Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor. Neuron 1995 Mar; 14(3):635-44.
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  94. Ohno K, Hutchinson DO, Milone M, Brengman JM, Bouzat C, Sine SM, Engel AG. Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the epsilon subunit. Proc Natl Acad Sci U S A 1995 Jan 31; 92(3):758-62.
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  95. Bouzat C, Bren N, Sine SM. Structural basis of the different gating kinetics of fetal and adult acetylcholine receptors. Neuron 1994 Dec; 13(6):1395-402.
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  96. Fu DX, Sine SM. Competitive antagonists bridge the alpha-gamma subunit interface of the acetylcholine receptor through quaternary ammonium-aromatic interactions. J Biol Chem 1994 Oct 21; 269(42):26152-7.
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  97. Sine SM, Quiram P, Papanikolaou F, Kreienkamp HJ, Taylor P. Conserved tyrosines in the alpha subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists. J Biol Chem 1994 Mar 25; 269(12):8808-16.
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  98. Kreienkamp HJ, Sine SM, Maeda RK, Taylor P. Glycosylation sites selectively interfere with alpha-toxin binding to the nicotinic acetylcholine receptor. J Biol Chem 1994 Mar 18; 269(11):8108-14.
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  99. Sine SM. Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine curare selectivity. Proc Natl Acad Sci U S A 1993 Oct 15; 90(20):9436-40.
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  100. Sine SM, Claudio T. Gamma- and delta-subunits regulate the affinity and the cooperativity of ligand binding to the acetylcholine receptor. J Biol Chem 1991 Oct 15; 266(29):19369-77.
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  101. Sine SM, Claudio T. Stable expression of the mouse nicotinic acetylcholine receptor in mouse fibroblasts. Comparison of receptors in native and transfected cells. J Biol Chem 1991 Jul 25; 266(21):13679-89.
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  102. Sine SM, Claudio T, Sigworth FJ. Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Single channel current kinetics reveal distinct agonist binding affinities. J Gen Physiol 1990 Aug; 96(2):395-437.
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  103. Sine SM. Functional properties of human skeletal muscle acetylcholine receptors expressed by the TE671 cell line. J Biol Chem 1988 Dec 5; 263(34):18052-62.
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  104. Claudio T, Green WN, Hartman DS, Hayden D, Paulson HL, Sigworth FJ, Sine SM, Swedlund A. Genetic reconstitution of functional acetylcholine receptor channels in mouse fibroblasts. Science 1987 Dec 18; 238(4834):1688-94.
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  105. Sigworth FJ, Sine SM. Data transformations for improved display and fitting of single-channel dwell time histograms. Biophys J 1987 Dec; 52(6):1047-54.
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  106. Sine SM, Steinbach JH. Activation of acetylcholine receptors on clonal mammalian BC3H-1 cells by high concentrations of agonist. J Physiol (Lond) 1987 Apr; 385:325-59.
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  107. Sine SM, Steinbach JH. Acetylcholine receptor activation by a site-selective ligand: nature of brief open and closed states in BC3H-1 cells. J Physiol (Lond) 1986 Jan; 370:357-79.
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  108. Sine SM, Steinbach JH. Activation of acetylcholine receptors by low concentrations of agonist. J Physiol 1986; 373:129-62.
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  109. Sine SM, Steinbach JH. Agonists block currents through acetylcholine receptor channels. Biophys J 1984 Aug; 46(2):277-83.
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  110. Sine SM, Steinbach JH. Activation of a nicotinic acetylcholine receptor. Biophys J 1984 Jan; 45(1):175-85.
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  111. Sine SM, Taylor P. Local anesthetics and histrionicotoxin are allosteric inhibitors of the acetylcholine receptor. Studies of clonal muscle cells. J Biol Chem 1982 Jul 25; 257(14):8106-4.
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  112. Taylor P, Sine SM. Ligand occupation and the functional states of nicotinic receptor. Trends Pharmacol Sci 1982; 3:197-200.
  113. Sine SM, Taylor P. Relationship between reversible antagonist occupancy and the functional capacity of the acetylcholine receptor. J Biol Chem 1981 Jul 10; 256(13):6692-9.
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  114. Sine SM, Taylor P. The relationship between agonist occupation and the permeability response of the cholinergic receptor revealed by bound cobra alpha-toxin. J Biol Chem 1980 Nov 10; 255(21):10144-56.
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  115. Taylor P, Weiland G, Sine SM, Chignell C, Brown R. Cholinergic receptor state transitions and local anesthetic action. Prog Anesthesiol 1980; 2:175-88.
  116. Sine S, Taylor P. Functional consequences of agonist-mediated state transitions in the cholinergic receptor. Studies in cultured muscle cells. J Biol Chem 1979 May 10; 254(9):3315-25.
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  117. Sine SM, Conklin TE, Okamura WH. Studies on vitamin D and its analogs. VI. 3-deoxy-A-homovitamin D3, a model synthesis. J Org Chem 1974 Dec 13; 39(25):3797-9.
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  118. Wing RM, Okamura WH, Pirio MR, Sine SM, Norman AW. Vitamin D in solution: conformations of vitamin D3, 1alpha,25-dihydroxyvitamin D3, and dihydrotachysterol3. Science 1974 Dec 6; 186(4167):939-41.
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