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Publications - Eduardo N . Chini, M.D., Ph.D.

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  1. Chini EN. CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditions. Curr Pharm Des 2009; 15(1):57-63.
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  2. Chini EN. CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditions. Curr Pharm Des 2009; 15(1):57-63.
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  3. Novak CM, Escande C, Gerber SM, Chini EN, Zhang M, Britton SL, Koch LG, Levine JA. Endurance Capacity, Not Body Size, Determines Physical Activity Levels: Role of Skeletal Muscle PEPCK. Plos One 2009.
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  4. Novak CM, Escande C, Gerber SM, Chini EN, Zhang M, Britton SL, Koch LG, Levine JA. Endurance capacity, not body size, determines physical activity levels: role of skeletal muscle PEPCK. PLoS One 2009; 4(6):e5869. Epub 2009 Jun 12.
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  5. Nagamune K, Hicks LM, Fux B, Brossier F, Chini EN, Sibley LD. Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii. Nature 2008 Jan 10; 451(7175):207-10.
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  6. Nagamune K, Moreno SN, Chini EN, Sibley LD. Calcium regulation and signaling in apicomplexan parasites. Subcell Biochem 2008; 47:70-81.
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  7. Nagamune K, Hicks LM, Fux B, Brossier F, Chini EN, Sibley LD. Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii. Nature 2008; 45:207-10.
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  8. Barbosa MT, Soares SM, Novak CM, Sinclair D, Levine JA, Aksoy P, Chini EN. The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity. FASEB J 2007 Nov; 21(13):3629-39. Epub 2007 Jun 21.
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  9. Perkins WJ, Taniguchi M, Warner DO, Chini EN, Jones KA. Reduction in soluble guanylyl cyclase-specific activity following prolonged treatment of porcine pulmonary artery with nitric oxide. Am J Physiol Lung Cell Mol Physiol 2007 Jul; 293(1):L84-95. Epub 2007 Mar 23.
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  10. Soares S, Thompson M, White T, Isbell A, Yamasaki M, Prakash Y, Lund FE, Galione A, Chini EN. NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells. Am J Physiol Cell Physiol 2007 Jan; 292(1):C227-39.
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  11. Barbosa MT, Soares SM, Novak CM, Sinclair D, Levine JA, Aksoy P, Chini EN. The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity. FASEB J 2007 (EPub ahead of print).
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  12. Perkins WJ, Taniguchi M, Warner DO, Chini EN, Jones KA. Reduction in soluble guanylyl cyclase specific activity following prolonged treatment of porcine pulmonary artery with nitric oxide. Am J Physiol Lung Cell Mol Physiol 2007; Epub ahead of print.
  13. Kip SN, Smelter M, Iyanoye A, Chini EN, Prakash YS, Pabelick CM, Sieck GC. Agonist-induced cyclic ADP ribose production in airway smooth muscle. Arch Biochem Biophys 2006 Aug 15; 452(2):102-7. Epub 2006 Jun 30.
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  14. Kip SN, Smelter M, Lyanoye A, Chini EN, Prakash YS, Pabelick CM, Sieck GC. Agonist-induced cyclic ADP ribose production in airway smooth muscle. Archives of Biochemistry & Biophysics 2006 Aug 15; 452(2):102-7.
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  15. Chini EN, Nagamune K, Wetzel DM, Sibley LD. Evidence that the cADPR signalling pathway controls calcium-mediated microneme secretion in Toxoplasma gondii. Biochem J 2005 Jul 15; 389(2):269-77.
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  16. Sen S, Chini EN, Brown MJ. Complications after unintentional intra-arterial injection of drugs: risks, outcomes, and management strategies. Mayo Clin Proc 2005 Jun; 80(6):783-95.
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  17. Soares SM, Thompson M, Chini EN. Role of the second-messenger cyclic-adenosine 5 '-diphosphate-ribose on adrenocorticotropin secretion from pituitary cells. Endocrinology 2005 May; 146(5):2186-92.
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  18. Burrow B, Burkle C, Warner DO, Chini EN. Postoperative outcome of patients with narcolepsy. A retrospective analysis. J Clin Anesth 2005 Feb; 17(1):21-5.
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  19. Thompson M, da Silva HB, Zielinska W, White TA, Bailey JP, Lund FE, Sieck GC, Chini EN. Role of CD38 in myometrial Ca2+ transients: modulation by progesterone. Am J Physiol Endocrinol Metab 2004 Dec; 287(6):E1142-8.
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  20. Chini EN, Brown MJ, Farrell MA, Charboneau JW. Hypertensive crisis in a patient undergoing percutaneous radiofrequency ablation of an adrenal mass under general anesthesia. Anesth Analg 2004 Dec; 99(6):1867-9.
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  21. Zielinska W, Barata H, Chini EN. Metabolism of cyclic ADP-ribose: Zinc is an endogenous modulator of the cyclase/NAD glycohydrolase ratio of a CD38-like enzyme from human seminal fluid. Life Sci 2004 Feb 20; 74(14):1781-90.
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  22. Barata H, Thompson M, Zielinska W, Han YS, Mantilla CB, Prakash YS, Feitoza S, Sieck G, Chini EN. The role of cyclic-ADP-ribose-signaling pathway in oxytocin-induced Ca2+ transients in human myometrium cells. Endocrinology 2004 Feb; 145(2):881-9. Epub 2003 Oct 16.
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  23. Chini EN. To be or not to be ... nicotinic acid adenine dinucleotide phosphate (NAADP): a new intracellular second messenger? Biol Res 2004; 37(4):559-63.
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  24. Chini EN, Chini CCS, da Silva HB, Zielinska W. The cyclic-ADP-ribose signaling pathway in human myometrium. Arch Biochem Biophys 2002 Nov 15; 407(2):152-9.
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  25. Chini EN, Keller TF, Prakash YS, Pabelick CM, Sieck G. Effect of halothane on cADP-ribose-induced Ca2+ release system in tracheal smooth muscle. Anesthesiology 2002 Oct; 97(4):1022-4.
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  26. Chini EN, De Toledo FGS. Nicotinic acid adenine dinucleotide phosphate: a new intracellular second messenger? Am J Physiol Cell Physiol 2002 Jun; 282(6):C1191-8.
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  27. Chini EN. Interactions between intracellular Ca2+ stores: Ca2+ released from the NAADP pool potentiates cADPR-induced Ca2+ release. Braz J Med Biol Res 2002 May; 35(5):543-7.
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  28. Chini EN, Chini CCS, Kato I, Takasawa S, Okamoto H. CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues. Biochem J 2002 Feb 15; 362(Part 1):125-30.
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  29. Chini EN. Signal transduction in smooth muscle: selected contribution: effect of volatile anesthetics on CAPD-ribose-induced Ca2+ release system. J Appl Physiol 2001 Jul; 91(1):516-521.
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  30. Yusufi AN, Cheng J, Thompson MA, Chini EN, Grande JP. Nicotinic acid-adenine dinucleotide phosphate (NAADP) elicits specific microsomal Ca2+ release from mammalian cells. Biochem J 2001 Feb 1; 353(Pt 3):531-6.
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  31. Cheng J, Yusufi AN, Thompson MA, Chini EN, Grande JP. Nicotinic acid adenine dinucleotide phosphate: a new Ca2+ releasing agent in kidney. J Am Soc Nephrol 2001 Jan; 12(1):54-60.
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  32. de Toledo FG, Cheng J, Liang M, Chini EN, Dousa TP. ADP-Ribosyl cyclase in rat vascular smooth muscle cells: properties and regulation. Circ Res 2000 Jun 9; 86(11):1153-9.
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  33. Chini EN, Walker H. FK506 (tacrolimus) increases halothane-induced Ca2+ release from skeletal muscle sarcoplasmic reticulum. Anesthesiology 2000 May; 92(5):1361-5.
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  34. Liang M, Chini EN, Cheng J, Dousa TP. Synthesis of NAADP and cADPR in mitochondria. Archives of Biochemistry & Biophysics 1999 Nov 15; 371(2):317-25.
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  35. Caride AJ, Chini EN, Penniston JT, Dousa TP. Selective decrease of mRNAs encoding plasma membrane calcium pump isoforms 2 and 3 in rat kidney. Kidney Int 1999 Nov; 56(5):1818-25.
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  36. Chini EN, Dousa TP. Differential effect of glycolytic intermediaries upon cyclic ADP-ribose-, inositol 1 ',4 ',5 '-triphosphate-, and nicotinate adenine dinucleotide phosphate-induced Ca2+ release systems. Arch Biochem Biophys 1999 Oct 15; 370(2):294-299.
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  37. Chini EN, Liang M, Dousa TP. Differential effect of pH upon cyclic-ADP-ribose and nicotinate-adenine dinucleotide phosphate-induced Ca2+ release systems. Biochem J 1998 Nov 1; 335(Pt 3):499-504.
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  38. Caride AJ, Chini EN, Homma S, Penniston JT, Dousa TP. mRNA encoding four isoforms of the plasma membrane calcium pump and their variants in rat kidney and nephron segments. Journal of Laboratory & Clinical Medicine 1998 Aug; 132(2):149-56.
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  39. Caride AJ, Chini EN, Homma S, Dousa TP, Penniston JT. mRNAs coding for the calcium-sensing receptor along the rat nephron: effect of a low-phosphate diet. Kidney Blood Press Res 1998; 21(5):305-9.
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  40. Chini EN, Chini CC, Bolliger C, Jougasaki M, Grande JP, Burnett JC Jr, Dousa TP. Cytoprotective effects of adrenomedullin in glomerular cell injury: central role of cAMP signaling pathway. Kidney Int 1997 Oct; 52(4):917-25.
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  41. Chini EN, de Toledo FG, Thompson MA, Dousa TP. Effect of estrogen upon cyclic ADP ribose metabolism: beta-estradiol stimulates ADP ribosyl cyclase in rat uterus. Proc Natl Acad Sci U S A 1997 May 27; 94(11):5872-6.
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  42. Chini EN, Klener P Jr, Beers KW, Chini CC, Grande JP, Dousa TP. Cyclic ADP-ribose metabolism in rat kidney: high capacity for synthesis in glomeruli. Kidney Int 1997 May; 51(5):1500-6.
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  43. Chini CC, Grande JP, Chini EN, Dousa TP. Compartmentalization of cAMP signaling in mesangial cells by phosphodiesterase isozymes PDE3 and PDE4. Regulation of superoxidation and mitogenesis. J Biol Chem 1997 Apr 11; 272(15):9854-9.
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  44. Chini EN, Thompson MA, Chini CCS, Dousa TP. Cyclic ADP-ribose signaling in sea urchin gametes - metabolism in spermatozoa. Am J Physiol Cell Physiol 1997 Feb; 272(2):C 416-C 420.
  45. Dousa TP, Chini EN, Beers KW. Adenine nucleotide diphosphates: emerging second messengers acting via intracellular Ca2+ release. Am J Physiol 1996 Oct; 271(4 Pt 1):C1007-24.
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  46. Chini EN, Dousa TP. Nicotinate-adenine dinucleotide phosphate-induced Ca2+ release does not behave as a Ca2+-induced Ca2+-release system. Biochem J 1996 Jun 15; 316(Part 3):709-711.
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  47. Beers KW, Thompson MA, Chini EN, Dousa TP. Beta-estradiol inhibits Na+-P(1) cotransport across renal brush border membranes from ovariectomized rats. Biochem Biophys Res Commun 1996 Apr 16; 221(2):442-445.
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  48. Chini EN, Dousa TP. Palmitoyl-CoA potentiates the Ca2+ release elicited by cyclic ADP-ribose. Am J Physiol Cell Physiol 1996 Feb; 270(2):C 530-C 537.
  49. Perez-Terzic CM, Chini EN, Shen SS, Dousa TP, Clapham DE. Ca2+ release triggered by nicotinate adenine dinucleotide phosphate in intact sea urchin eggs. Biochem J 1995 Dec 15; 312(Pt 3):955-9.
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  50. Caride AJ, Chini EN, Yamaki M, Dousa TP, Penniston JT. Unique localization of mRNA encoding plasma membrane Ca2+ pump isoform 3 in rat thin descending loop of Henle. Am J Physiol 1995 Nov; 269(5 Pt 2):F681-5.
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  51. Chini EN, Choi E, Grande JP, Burnett JC, Dousa TP. Adrenomedullin suppresses mitogenesis in rat mesangial cells via cAMP pathway. Biochem Biophys Res Commun 1995 Oct 24; 215(3):868-73.
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  52. Chini EN, Beers KW, Chini CC, Dousa TP. Specific modulation of cyclic ADP-ribose-induced Ca2+ release by polyamines. Am J Physiol 1995 Oct; 269(4 Pt 1):C1042-7.
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  53. Matousovic K, Grande JP, Chini CC, Chini EN, Dousa TP. Inhibitors of cyclic nucleotide phosphodiesterase isozymes type-III and type-IV suppress mitogenesis of rat mesangial cells. J Clin Invest 1995 Jul; 96(1):401-10.
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  54. Beers KW, Chini EN, Dousa TP. All-trans-retinoic acid stimulates synthesis of cyclic ADP-ribose in renal llc-pk1 cells. J Clin Invest 1995 May; 95:2385-90.
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  55. de Toledo FG, Albuquerque MC, Goulart BH, Chini EN. Different thermostabilities of sarcoplasmic reticulum (Ca2+ + Mg2+)-ATPases from rabbit and trout muscles. Comparative Biochemistry & Physiology. Part C Pharmacology, Toxicology, Endocrinology 1995 May; 111(1):93-8.
  56. Chini EN, Dousa TP. Enzymatic synthesis and degradation of nicotinate adenine dinucleotide phosphate (NAADP), a Ca2+- releasing agonist in rat tissues. Biochem Biophys Res Commun 1995 Apr 6; 209:167-174.
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  57. Beers KW, Chini EN, Lee HC, Dousa TP. Metabolism of cyclic ADP-ribose in opossum kidney renal epithelial cells. Am J Physiol 1995 Mar; 37:C741-C746.
  58. Chini EN, Beers KW, Dousa TP. Nicotinate adenine dinucleotide phosphate (NAADP) triggers a specific calcium release system in sea urchin eggs. J Biol Chem 1995 Feb 17; 270(7):3216-23.
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  59. Chini CC, Chini EN, Williams JM, Matousovic K, Dousa TP. Formation of reactive oxygen metabolites in glomeruli is suppressed by inhibition of cAMP phosphodiesterase isozyme type IV. Kidney Int 1994 Jul; 46(1):28-36.
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  60. Chini EN, de Toledo FG, Albuquerque MC, de Meis L. The Ca(2+)-transporting ATPases of rabbit and trout exhibit different pH- and temperature dependences Biochem J 1993; 293:469-73.
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  61. Chini EN, de Faria FO, Cardoso CM, de Meis L. The enhancement of Ca2+ efflux from sarcoplasmic reticulum vesicles by urea Arch Biochem Biophys 1992; 299:73-6.
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  62. Chini EN, Meyer-Fernandes JR, Sola-Penna M. Monosaccharides and disaccharides decrease the Km for phosphorylation of a membrane-bound enzyme ATPase. Z Naturforsch [C] 1991; 46:644-6.
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  63. Chini EN, Montero-Lomeli M, de Meis L. K(+)- and Mg2(+)-dependent hydrolysis of acetyl phosphate catalyzed by the (Ca2+ + Mg2+)-ATPase of sarcoplasmic reticulum. Biochim et Biophys Acta 1990; 1030:152-6.
  64. Chini EN, Montero-Lomeli M, de Meis L. K(+)- and Mg2(+)-dependent hydrolysis of acetyl phosphate catalyzed by the (Ca2+ + Mg2+)-ATPase of sarcoplasmic reticulum. Biochim Biophys Acta 1990 Nov 30; 1030(1):152-6.
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  65. Chini EN, de Faria FO, Cardoso CM, de Meis L. The enhancement of Ca2+ efflux from sarcoplasmic reticulum vesicles by urea. Arch Biochem Biophys 1992 Nov 15; 299(1):73-6.
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  66. Chini EN, de Toledo FG, Albuquerque MC, de Meis L. The Ca(2+)-transporting ATPases of rabbit and trout exhibit different pH- and temperature-dependences. Biochem J 1993 Jul 15; 293 ( Pt 2):469-73.
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  67. Chini EN, Meyer-Fernandes JR, Sola-Penna M. Monosaccharides and disaccharides decrease the Km for phosphorylation of a membrane-bound enzyme ATPase. Z Naturforsch [C] 1991 Jul-Aug; 46(7-8):644-6.
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