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Publications - Dennis J . O'Kane, Ph.D.

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  1. Snozek CL, Mascarenhas RC, O'Kane DJ. Use of cyst fluid CEA, CA19-9, and amylase for evaluation of pancreatic lesions. Clin Biochem 2009 Oct; 42(15):1585-8. Epub 2009 Jul 02.
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  2. Kramer WE, Walker DL, O'Kane DJ, Mrazek DA, Fisher PK, Dukek BA, Bruflat JK, Black JL. CYP2D6: novel genomic structures and alleles. Pharmacogenet Genomics 2009 Oct; 19(10):813-22.
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  3. Snozek CL, O'Kane DJ, Algeciras-Schimnich A. Pharmacogenetics of solid tumors: directed therapy in breast, lung, and colorectal cancer: a paper from the 2008 william beaumont hospital symposium on molecular pathology. J Mol Diagn 2009 Sep; 11(5):381-9. Epub 2009 Jul 30.
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  4. Snozek CLH, O'Kane DJ, Algeciras-Schimnich A. Pharmacogenetics of solid tumors: directed therapy in breast, lung, and colorectal cancer: a paper from the 2008 William Beaumont Hospital Symposium on Molecular Pathology. J Mol Diagn 2009 Sep; 11(5):381-9.
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  5. Mrazek DA, Rush AJ, Biernacka JM, O'Kane DJ, Cunningham JM, Wieben ED, Schaid DJ, Drews MS, Courson VL, Snyder KA, Black JL 3rd, Weinshilboum RM. SLC6A4 variation and citalopram response. Am J Med Genet B Neuropsychiatr Genet 2009 Apr 5; 150B(3):341-51.
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  6. Algeciras-Schimnich A, O'Kane DJ, Snozek CL. Pharmacogenomics of tamoxifen and irinotecan therapies. Clin Lab Med 2008 Dec; 28(4):553-67.
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  7. Flockhart DA, O'Kane D, Williams MS, Watson MS, Flockhart DA, Gage B, Gandolfi R, King R, Lyon E, Nussbaum R, O'Kane D, Schulman K, Veenstra D, Williams MS, Watson MS, ACMG Working Group on Pharmacogenetic Testing of CYP2C9, VKORC1 Alleles for Warfarin Us Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin. Genet Med 2008 Feb; 10(2):139-50.
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  8. Flockhart DA, O'Kane D, Williams MS, Watson MS, Flockhart DA, Gage B, Gandolfi R, King R, Lyon E, Nussbaum R, O'Kane D, Schulman K, Veenstra D, Williams MS, Watson MS, ACMG Working Group on Pharmacogenetic Testing of CYP2C9, VKORC1 Alleles for Warfarin Us Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin. Genet Med 2008 Feb; 10(2):139-50.
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  9. Flockhart DA, O'Kane D, Williams MS, Watson MS, Flockhart DA, Gage B, Gandolfi R, King R, Lyon E, Nussbaum R, O'Kane D, Schulman K, Veenstra D, Williams MS, Watson MS, ACMG Working Group on Pharmacogenetic Testing of CYP2C9 VKORC1 Alleles for Warfarin Use Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin. Genet Med 2008 Feb; 10(2):139-50.
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  10. Flockhart DA, O'Kane D, Williams MS, Watson MS, Gage B, Gandolfi R, King R, Lyon E, Nussbaum R, Schulman K, Veenstra D. Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin. Genet Med 2008 Feb; 10(2):139-50.
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  11. Flockhart DA, O'Kane D, Williams MS, Watson MS, Flockhart DA, Gage B, Gandolfi R, King R, Lyon E, Nussbaum R, O'Kane D, Schulman K, Veenstra D, Williams MS, Watson MS, ACMG Working Group on Pharmacogenetic Testing of CYP2C9, VKORC1 Alleles for Warfarin Us Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin. Genet Med 2008 Feb; 10(2):139-50.
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  12. Flockhart DA, O'Kane D, Williams MS, Watson MS, Flockhart DA, Gage B, Gandolfi R, King R, Lyon E, Nussbaum R, O'Kane D, Schulman K, Veenstra D, Williams MS, Watson MS, ACMG Working Group on Pharmacogenetic Testing of CYP2C9 VKORC1 Alleles for Warfarin Use Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin. Genet Med 2008 Feb; 10(2):139-50.
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  13. Baudhuin LM, Langman LJ, O'Kane DJ. Translation of pharmacogenetics into clinically relevant testing modalities. Clin Pharmacol Ther 2007 Oct; 82(4):373-6.
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  14. McAlpine DE, O'Kane DJ, Black JL, Mrazek DA. Cytochrome P450 2D6 genotype variation and venlafaxine dosage. Mayo Clin Proc 2007 Sep; 82(9):1065-8.
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  15. Baudhuin LM, Highsmith WE, Skierka J, Holtegaard L, Moore BE, O'Kane DJ. Comparison of three methods for genotyping the UGT1A1 (TA)n repeat polymorphism. Clin Biochem 2007 Jun; 40(9-10):710-7. Epub 2007 Mar 23.
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  16. Baudhuin LM, Highsmith WE, Skierka J, Holtegaard L, Moore BE, O'Kane DJ. Comparison of three methods for genotyping the UGT1A1 (TA)n repeat polymorphism. Clin Biochem 2007 Jun; 40(9-10):710-7. Epub 2007 Mar 23.
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  17. Black JL 3rd, O'Kane DJ, Mrazek DA. The impact of CYP allelic variation on antidepressant metabolism: a review. Expert Opin Drug Metab Toxicol 2007 Feb; 3(1):21-31.
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  18. Preissner CM, Reilly WM, Cyr RC, O'Kane DJ, Singh RJ, Grebe SKG. Plastic versus glass tubes: Effects on analytical performance of selected serum and plasma hormone assays. Clin Chem 2004 Jul; 50(7):1245-7.
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  19. Lagerstedt SA, O'Kane DJ, Singh RJ. Measurement of plasma free metanephrine and normetanephrine by liquid chromatographym-tandem mass spectrometry for diagnosis of pheochromocytoma. Clin Chem 2004 Mar; 50(3):603-11.
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  20. Khurana VG, Sohni TR, Mangrum WI, McClelland RL, O'Kane DJ, Meyer FB, Meissner I. Endothelial nitric oxide synthase gene polymorphisms predict susceptibility to aneurysmal subarachnoid hemorrhage and cerebral vasospasm. J Cereb Blood Flow Metab 2004 Mar; 24(3):291-7.
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  21. Nelson RE, Grebe SK, O'Kane DJ, Singh RJ. Liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of estradiol and estrone in human plasma. Clin Chem 2004 Feb; 50(2):373-84.
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  22. Khurana VG, Sohni YR, Mangrum WI, McClelland RL, O'Kane DJ, Meyer FB, Meissner I. Section on cerebrovascular surgery: Galbraith Award: Endothelial nitric oxide synthase (eNOS) and heme oxygenase-1 (HO-1) gene polymorphisms predict susceptibility to aneurysmal subarachnoid hemorrhage (SAH) and post-SAH cerebral vasospasm. Clin Neurosurg 2004; 51:343-50.
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  23. Khurana VG, Sohni YR, Mangrum WI, McClelland RL, O'Kane DJ, Meyer FB, Meissner I. Endothelial nitric oxide synthase T-786C single nucleotide polymorphism - A putative genetic marker differentiating small versus large ruptured intracranial aneurysms. Stroke 2003 Nov; 34(11):2555-9.
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  24. Preissner CM, O'Kane DJ, Singh RJ, Morris JC, Grebe SKG. Phantoms in the assay tube: Heterophile antibody interferences in serum thyroglobulin assays. J Clin Endocrinol Metab 2003 Jul; 88(7):3069-74.
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  25. Bhuiyan J, Akhter J, O'Kane DJ. Performance characteristics of multiple urinary tumor markers and sample collection techniques in the detection of transitional cell carcinoma of the bladder. Clin Chim Acta 2003 May; 331(1-2):69-77.
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  26. Sohni YR, Burke JP, Dyck PJ, O'Kane DJ. Microfluidic chip-based method for genotyping microsatellites, VNTRs and insertion/deletion polymorphisms. Clin Biochem 2003 Feb; 36(1):35-40.
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  27. Ricart E, Taylor WR, Loftus EV, O'Kane D, Weinshilboum RM, Tremaine WJ, Harmsen WS, Zinsmeister AR, Sandborn WJ. N-acetyltransferase 1 and 2 genotypes do not predict response or toxicity to treatment with mesalamine and sulfasalazine in patients with ulcerative colitis. Am J Gastroenterol 2002 Jul; 97(7):1763-8.
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  28. Halling KC, King W, Sokolova IA, Karnes RJ, Meyer RG, Powell EL, Sebo TJ, Cheville JC, Clayton AC, Krajnik KL, Ebert TA, Nelson RE, Burkhardt HM, Ramakumar S, Stewart CS, Pankratz VS, Lieber MM, Blute ML, Zincke H, Seelig SA, Jenkins RB, O'Kane DJ. A comparison of BTA stat, hemoglobin dipstick, telomerase and vysis urovysion assays for the detection of urothelial carcinoma in urine. J Urol 2002 May; 167(5):2001-6.
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  29. Peng KW, Facteau S, Wegman T, O'Kane D, Russell SJ. Non-invasive in vivo monitoring of trackable viruses expressing soluble marker peptides. Nat Med 2002 May; 8(5):527-31.
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  30. Dhiman N, Bonilla R, O'Kane D, Poland GA. Gene expression microarrays: a 21st century tool for directed vaccine design. Vaccine 2001 Oct 12; 20(1-2):22-30.
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  31. Nagan N, O'Kane DJ. Validation of a single nucleotide polymorphism genotyping assay for the human serum paraoxonase gene using electronically active customized microarrays. Clin Biochem 2001 Oct; 34(7):589-92.
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  32. Dowdy SC, O'Kane DJ, Keeney GL, Boyd J, Podratz KC. Telomerase activity in sex cord-stromal tumors of the ovary. Gynecol Oncol 2001 Aug; 82(2):257-60.
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  33. Wang Y, Wang G, O'Kane DJ, Szalay AA. A study of protein-protein interactions in living cells using luminescence resonance energy transfer (LRET) from Renilla luciferase to Aequorea GFP. Molecular & General Genetics 2001 Jan; 264(5):578-87.
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  34. Sohni YR, Dukek B, Taylor W, Ricart E, Sandborn WJ, O'Kane DJ. Active electronic arrays for genotyping NAT2 polymorphisms. Clin Chem 2001 47; 47:1922-24.
  35. Halling KC, King W, Sokolova IA, Meyer RG, Burkhardt HM, Halling AC, Cheville JC, Sebo TJ, Ramakumar S, Stewart CS, Pankratz S, O'Kane DJ, Seelig SA, Lieber MM, Jenkins RB. A comparison of cytology and fluorescence in situ hybridization for the detection of urothelial carcinoma. J Urol 2000 Nov; 164(5):1768-75.
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  36. Bush VJ, Hallaway BJ, Ebert TA, Wilson DM, O'Kane DJ. Chemiluminescence screening assays for erythrocytes and leukocytes in urine. Methods Enzymol 2000; 305:402-10.
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  37. Tenner KS, O'Kane DJ. Clinical application of Southern blot hybridization with chemiluminescence detection. Methods Enzymol 2000; 305:450-66.
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  38. O'Kane DJ, Lee J. Absolute calibration of luminometers with low-level light standards. Methods Enzymol 2000; 305:87-96.
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  39. Hallaway BJ, O'Kane DJ. Chemiluminescence assay of serum alkaline phosphatase and phosphoprotein phosphatases. Methods Enzymol 2000; 305:391-401.
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  40. Ramakumar S, Bhuiyan J, Besse JA, Roberts SC, Wollan PC, Blute ML, O'Kane DJ. Comparison of screening methods in detection of bladder cancer. J Urol 1999 Feb; 161(2):388-394.
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  41. Baron AT, Lafky JM, Connolly DC, Peoples J, O'Kane DJ, Suman VJ, Boardman CH, Podratz KC, Maihle NJ. A sandwich type acridinium-linked immunosorbent assay (ALISA) detects soluble ErbB1 (sErbB1) in normal human sera. J Immunol Methods 1998 Oct 1; 219(1-2):23-43.
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  42. Liu J, O'Kane DJ, Escher A. Secretion of functional Renilla reniformis luciferase by mammalian cells. Gene 1997 Dec 12; 203(2):141-8.
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  43. Korf GM, Landers JP, O'Kane DJ. Capillary electrophoresis with laser-induced fluorescence detection for the analysis of free and immune-complexed green fluorescent protein. Anal Biochem 1997 Sep 5; 251(2):210-8.
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  44. O'Kane DJ, Ebert TA, Hallaway BJ, Roberts SG, Bhuiyan AK, Tenner KS. A laboratorian's perspective on evaluation and implementation of new laboratory tests. Clin Chem 1997 Sep; 43(9):1771-80.
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  45. Lorenz WW, Cormier MJ, O'Kane DJ, Hua D, Escher AA, Szalay AA. Expression of the Renilla reniformis luciferase gene in mammalian cells. Journal of Bioluminescence & Chemiluminescence 1996 Jan-Feb; 11(1):31-7.
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  46. Ehrig T, O'Kane DJ, Prendergast FG. Green-fluorescent protein mutants with altered fluorescence excitation spectra. FEBS Lett 1995 Jun 26; 367(2):163-6.
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  47. Lee CY, O'Kane DJ, Meighen EA. Riboflavin synthesis genes are linked with the lux operon of Photobacterium phosphoreum. J Bacteriol 1994 Apr; 176(7):2100-4.
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  48. Moore SA, James MN, O'Kane DJ, Lee J. Crystal structure of a flavoprotein related to the subunits of bacterial luciferase. EMBO J 1993 May; 12(5):1767-74.
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  49. Lee J, Gibson BG, O'Kane DJ, Kohnle A, Bacher A. Fluorescence study of the ligand stereospecificity for binding to lumazine protein. Eur J Biochem 1992 Dec 15; 210(3):711-9.
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  50. Moore SA, James MN, O'Kane DJ, Lee J. Crystallization of Photobacterium leiognathi non-fluorescent flavoprotein, an unusual flavoprotein with limited sequence identity to bacterial luciferase. J Mol Biol 1992 Mar 20; 224(2):523-6.
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  51. Stults NL, Stocks NF, Rivera H, Gray J, McCann RO, O'Kane D, Cummings RD, Cormier MJ, Smith DF. Use of recombinant biotinylated aequorin in microtiter and membrane-based assays: purification of recombinant apoaequorin from Escherichia coli. Biochemistry 1992 Feb 11; 31(5):1433-42.
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  52. O'Kane DJ, Prasher DC. Evolutionary origins of bacterial bioluminescence. Mol Microbiol 1992 Feb; 6(4):443-9.
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  53. Lingle WL, Porter D, O'Kane DJ. Preliminary analysis of genetic complementation of bioluminescence in Panellus stypticus isolated from pine and hardwood. Mycologia 1992; 84:94-104.
  54. Lee J, Bradley EA, O'Kane DJ. Protein structure, spectral properties, and photobiological function of lumazine protein. Proc Soc Photo-Opt Instr Eng 1992; 1640:148-158.
  55. Escher A, O'Kane DJ, Szalay AA. The beta subunit polypeptide of Vibrio harveyi luciferase determines light emission at 42 degrees C. Molecular & General Genetics 1991 Dec; 230(3):385-93.
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  56. O'Kane DJ, Woodward B, Lee J, Prasher DC. Borrowed proteins in bacterial bioluminescence. Proc Natl Acad Sci U S A 1991 Feb 15; 88(4):1100-4.
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  57. Prasher DC, O'Kane D, Lee J, Woodward B. The lumazine protein gene in Photobacterium phosphoreum is linked to the lux operon. Nucleic Acids Res 1990 Nov 11; 18(21):6450.
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  58. O'Kane DJ, Lee J. Encapsulated radiophosphorescent standards for day-to-day photometer calibration. Photochemistry & Photobiology 1990 Oct; 52(4):723-34.
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  59. Vervoort J, O'Kane DJ, Muller F, Bacher A, Strobl G, Lee J. 13C and 15N NMR studies on the interaction between 6,7-dimethyl-8-ribityllumazine and lumazine protein. Biochemistry 1990 Feb 20; 29(7):1823-8.
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  60. O'Kane DJ, Lingle WL, Porter D, Wampler JE. Localization of bioluminescent tissues during basidiocarp development in Panellus stypticus. Mycologia 1990; 82:595-605.
  61. O'Kane DJ, Lingle WL, Porter D, Wampler JE. Spectral analysis of the bioluminescence of Panellus stypticus. Mycologia 1990; 82:606-615.
  62. Lee J, Holtom GR, O'Kane DJ. Picosecond resolution study of intramolecular energy transfer in lumazine protein. Proc Photo-Opt Instr Eng 1990; 1204:581-589.
  63. Lee J, Yanyun W, Gibson BG, O'Kane DJ. Fluorescence dynamics measurements of energy transfer in the bacterial luciferase and lumazine protein interaction. Proc Photo-Opt Instr Eng 1990; 1204:706-716.
  64. Escher A, O'Kane DJ, Lee J, Szalay AA. Bacterial luciferase alpha beta fusion protein is fully active as a monomer and highly sensitive in vivo to elevated temperature. Proc Natl Acad Sci U S A 1989 Sep; 86(17):6528-32.
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  65. Lee J, O'Kane DJ, Gibson BG. Bioluminescence spectral and fluorescence dynamics study of the interaction of lumazine protein with the intermediates of bacterial luciferase bioluminescence. Biochemistry 1989 May 16; 28(10):4263-71.
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  66. Lee J, O'Kane DJ, Gibson BG. Dynamic fluorescence study of the interaction of lumazine protein with bacterial luciferases. Biophys Chem 1989 Mar; 33(1):99-111.
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  67. Vervoort J, O'Kane DJ, Muller F, Bacher A, Lee J. 13C and 15N NMR studies on the interaction between 6, 7-dimethyl-8-ribityl-lumazine protein. Biochemistry 1989; 28:1823-1828.
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  68. Escher A, O'Kane DJ, Lee J, Langridge WHR, Szalay AA. Construction of a novel functional bacterial luciferase by gene fusion. Proc Soc Photo-Opt Instr Eng 1989; 1161:230-235.
  69. Langridge WHR, Escher A, Baga M, O'Kane DJ, Wampler J, Koncz C, Schell J, Szalay AA. Use of genetically engineered bacterial luciferase to monitor gene regulation in living cells and gene activation throughout the development of a transgenic organism. Proc Soc Photo-Opt Instr Eng 1989; 1161:216-229.
  70. O'Kane DJ, Wampler JE. A variable intensity electroluminescence standard for video microscopy. Proc Soc Photo-Opt Eng 1989; 1161:205-215.
  71. Visser AJ, van Hoek A, O'Kane DJ, Lee J. Time-resolved fluorescence spectroscopy of lumazine protein from Photobacterium phosphoreum using synchrotron radiation. Eur Biophys J 1989; 17(2):75-85.
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  72. Lee J, O'Kane DJ, Gibson BG. Dynamic fluorescence properties of bacterial luciferase intermediates. Biochemistry 1988 Jun 28; 27(13):4862-70.
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  73. O'Kane DJ, Lingle WL, Wampler JE, Legocki RP, Legocki M, Szalay AA. Visualization of bioluminescence as a marker of gene expression in Rhizobium-infected soybean root nodules. Plant Mol Biol 1988; 10:387-399.
  74. Kulinski T, Visser AJ, O'Kane DJ, Lee J. Spectroscopic investigations of the single tryptophan residue and of riboflavin and 7-oxolumazine bound to lumazine apoprotein from Photobacterium leiognathi. Biochemistry 1987 Jan 27; 26(2):540-9.
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  75. Matheson IB, O'Kane DJ, Lee J. Free radical participation in bacterial bioluminescence. Free Radic Res Commun 1986; 2(1-2):1-5.
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  76. O'Kane DJ, Lee J. Purification and properties of lumazine proteins from Photobacterium strains. Methods Enzymol 1986; 133:149-72.
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  77. O'Kane DJ, Ahmad M, Matheson IB, Lee J. Purification of bacterial luciferase by high-performance liquid chromatography. Methods Enzymol 1986; 133:109-28.
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  78. Vervoort J, Muller F, O'Kane DJ, Lee J, Bacher A. Bacterial luciferase: a carbon-13, nitrogen-15, and phosphorus-31 nuclear magnetic resonance investigation. Biochemistry 1986; 25:8067-8075.
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  79. Visser AJ, Ykema T, van Hoek A, O'Kane DJ, Lee J. Determination of rotational correlation times from deconvoluted fluorescence anisotropy decay curves. Demonstration with 6,7-dimethyl-8- ribityllumazine and lumazine protein from photobacterium Leiognathus as fluorescent indicators. Biochemistry 1985 Mar 12; 24(6):1489-96.
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  80. O'Kane DJ, Lee J. Physical characterization of lumazine proteins from photobacterium. Biochemistry 1985 Mar 12; 24(6):1484-8.
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  81. O'Kane DJ, Lee J. Chemical characterization of lumazine protein from photobacterium Leiognathus: comparison with lumazine protein from photobacterium phosphoreum. Biochemistry 1985 Mar 12; 24(6):1467-75.
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  82. O'Kane DJ, Karle VA, Lee J. Purification of lumazine proteins from photobacterium Leiognathus and photobacterium phosphoreum: bioluminescence properties. Biochemistry 1985 Mar 12; 24(6):1461-7.
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  83. Lee J, O'Kane DJ, Visser AJ. Spectral properties and function of two lumazine proteins from photobacterium. Biochemistry 1985 Mar 12; 24(6):1476-83.
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  84. Rigsby WE, Lingle WL, O'Kane DJ, Lee J. Examination of penetrable volumes ('pores') in a high performance size exclusion chromatography matrix. Proc Elec Microscope Soc Amer 1985; 43:386-387.
  85. Visser AJ, Vervoort J, O'Kane DJ, Lee J, Carreira LA. Raman spectra of flavin bound in flavodoxins and in other flavoproteins. Evidence for structural variations in the flavin-binding region. Eur J Biochem 1983 Apr 5; 131(3):639-45.
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  86. Vervoort J, O'Kane DJ, Carriera L, Lee J. Identification of a lumazine protein from photobacterium Leiognathi by coherent anti-stokes Raman spectography. Photochem Photobiol 1983; 37:117-9.
  87. Palevitz BA, O'kane DJ. Epifluorescence and Video Analysis of Vacuole Motility and Development in Stomatal Cells of Allium. Science 1981 Oct 23; 214(4519):443-445.
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  88. Palevitz BA, O'Kane DJ. The vacuole system in stomatal cells of allium. Vacuole movements and changes in morphology in differentiating cells as revealed by epifluorescence, video and electron microscope. Protoplasma 1981; 109:23-55.
  89. O'Kane DJ, Levenson RG, Jones RF. A rapid and sensitive method for the detection of histone peptides. Anal Biochem 1978 May; 86(1):214-9.
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