Publications - Wilma Lingle, Ph.D.

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1. Lukasiewicz KB, Lingle WL. Aurora A, centrosome structure, and the centrosome cycle. Environ Mol Mutagen 2009 Oct; 50(8 Special Issue SI):602-19.
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2. Pei H, Li L, Fridley BL, Jenkins GD, Kalari KR, Lingle W, Petersen G, Lou Z, Wang L. FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell 2009 Sep 8; 16(3):259-66.
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3. Pei HD, Li L, Fridley BL, Jenkins GD, Kalari KR, Lingle W, Petersen G, Lou ZK, Wang LW. FKBP51 affects cancer cell response to chemotherapy by negatively regulating akt. Cancer Cell 2009 Sep 8; 16(3):259-66.
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4. Fu Z, Regan K, Zhang L, Muders MH, Thibodeau SN, French A, Wu Y, Kaufmann SH, Lingle WL, Chen J, Tindall DJ. Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice. J Clin Invest 2009 Sep; 119(9):2714-24. Epub 2009 Aug 17.
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5. Fu Z, Regan K, Zhang LZ, Muders MH, Thibodeau SN, French A, Wu YH, Kaufmann SH, Lingle WL, Chen JJ, Tindall DJ. Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice. J Clin Invest 2009 Sep; 119(9):2714-24.
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6. Litzow MR, Peethambaram PP, Safgren SL, Keeney GL, Ansell SM, Dispenzieri A, Elliott MA, Gastineau DA, Gertz MA, Inwards DJ, Lacy MQ, Micallef IN, Porrata LF, Lingle WL, Hartmann LC, Frost MH, Barrette BA, Long HJ, Suman VJ, Reid JM, Ames MM, Kaufmann Phase I trial of autologous hematopoietic SCT with escalating doses of topotecan combined with CY and carboplatin in patients with relapsed or persistent ovarian or primary peritoneal carcinoma. Bone Marrow Transplant 2009 Aug 03. [Epub ahead of print]
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7. Chien J, Fan JB, Bell DA, April C, Klotzle B, Ota T, Lingle WL, Gonzalez Bosquet J, Shridhar V, Hartmann LC. Analysis of gene expression in stage I serous tumors identifies critical pathways altered in ovarian cancer. Gynecol Oncol 2009 Jul; 114(1):3-11. Epub 2009 May 01.
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8. Reinholz MM, Bruzek AK, Visscher DW, Lingle WL, Schroeder MJ, Perez EA, Jenkins RB. Breast cancer and aneusomy 17: implications for carcinogenesis and therapeutic response. Lancet Oncol 2009 Mar; 10(3):267-77.
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9. Moreno-Aspitia A, Morton RF, Hillman DW, Lingle WL, Rowland KM Jr, Wiesenfeld M, Flynn PJ, Fitch TR, Perez EA. Phase II trial of sorafenib in patients with metastatic breast cancer previously exposed to anthracyclines or taxanes: North Central Cancer Treatment Group and Mayo Clinic Trial N0336. J Clin Oncol 2009 Jan 1; 27(1):11-5. Epub 2008 Dec 01.
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10. Balan V, Nangia-Makker P, Schwartz AG, Jung YS, Tait L, Hogan V, Raz T, Wang Y, Yang ZQ, Wu GS, Guo Y, Li H, Abrams J, Couch FJ, Lingle WL, Lloyd RV, Ethier SP, Tainsky MA, Raz A. Racial disparity in breast cancer and functional germ line mutation in galectin-3 (rs4644): a pilot study. Cancer Res 2008 Dec 15; 68(24):10045-50.
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11. Balan V, Nangia-Makker P, Schwartz AG, Jung YS, Tait L, Hogan V, Raz T, Wang Y, Yang ZQ, Wu GS, Guo YJ, Li HX, Abrams L, Couch FJ, Lingle WL, Lloyd RV, Ethier SP, Tainsky MA, Raz A. Racial Disparity in Breast Cancer and Functional Germ Line Mutation in Galectin-3 (rs4644): A Pilot Study. Cancer Research 2008 Dec 15; 68(24):10045-10050.
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12. McCollum AK, Lukasiewicz KB, Teneyck CJ, Lingle WL, Toft DO, Erlichman C. Cisplatin abrogates the geldanamycin-induced heat shock response. Mol Cancer Ther 2008 Oct; 7(10):3256-64.
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13. Goetz MP, Suman VJ, Couch FJ, Ames MM, Rae JM, Erlander MG, Ma XJ, Sgroi DC, Reynolds CA, Lingle WL, Weinshilboum RM, Flockhart DA, Desta Z, Perez EA, Ingle JN. Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance. Clin Cancer Res 2008 Sep 15; 14(18):5864-8.
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14. Gilbert JA, Goetz MP, Reynolds CA, Ingle JN, Giordano KF, Suman VJ, Blair HE, Jenkins RB, Lingle WL, Reinholz MM, Adjei AA, Ames MM. Molecular analysis of metaplastic breast carcinoma: high EGFR copy number via aneusomy. Mol Cancer Ther 2008 Apr; 7(4):944-51.
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15. Visscher DW, Pankratz VS, Santisteban M, Reynolds C, Ristimaki A, Vierkant RA, Lingle WL, Frost MH, Hartmann LC. Association between cyclooxygenase-2 expression in atypical hyperplasia and risk of breast cancer. J Natl Cancer Inst 2008 Mar 19; 100(6):421-7. Epub 2008 Mar 11.
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16. Hontz AE, Li SA, Salisbury JL, Lingle WL, Li JJ. Expression of selected Aurora A kinase substrates in solely estrogen-induced ectopic uterine stem cell tumors in the Syrian hamster kidney. Adv Exp Med Biol 2008; 617:411-8.
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17. Hartmann LC, Keeney GL, Lingle WL, Christianson TJ, Varghese B, Hillman D, Oberg AL, Low PS. Folate receptor overexpression is associated with poor outcome in breast cancer. Int J Cancer 2007 Sep 1; 121(5):938-42.
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18. Degnim AC, Visscher DW, Berman HK, Frost MH, Sellers TA, Vierkant RA, Maloney SD, Pankratz VS, de Groen PC, Lingle WL, Ghosh K, Penheiter L, Tlsty T, Melton LJ 3rd, Reynolds CA, Hartmann LC. Stratification of breast cancer risk in women with atypia: a Mayo cohort study. J Clin Oncol 2007 Jul 1; 25(19):2671-7. Epub 2007 Jun 11.
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19. Narita K, Chien J, Mullany SA, Staub J, Qian X, Lingle WL, Shridhar V. Loss of HSulf-1 expression enhances autocrine signaling mediated by amphiregulin in breast cancer. J Biol Chem 2007 May 11; 282(19):14413-20.
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20. Hontz AE, Li SA, Lingle WL, Negron V, Bruzek A, Salisbury JL, Li JJ. Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasia. Cancer Res 2007 Apr 1; 67(7):2957-63.
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21. Hontz AE, Li SA, Lingle WL, Negron V, Bruzek A, Salisbury JL, Li JJ. Aurora A and B Overexpression and Centrosome Amplification in Early Estrogen-Induced Tumor Foci in the Syrian Hamster Kidney: Implications for Chromosomal Instability, Aneuploidy, and Neoplasia. Cancer Research. 2007 Apr 1; 67(7):2957-2963.
22. Goetz MP, Knox SK, Suman VJ, Rae JM, Safgren SL, Ames MM, Visscher DW, Reynolds C, Couch FJ, Lingle WL, Weinshilboum RM, Fritcher EG, Nibbe AM, Desta Z, Nguyen A, Flockhart DA, Perez EA, Ingle JN. The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen. Breast Cancer Res Treat 2007 Jan; 101(1):113-21. Epub 2006 Nov 18.
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23. Degnim AC, Visscher DW, Berman HK, Frost MH, Sellers TA, Vierkant RA, Maloney SD, Pankratz VS, de Groen PC, Lingle WL, Ghosh K, Penheiter L, Tlsty T, Melton LJ III, Reynolds CA, Hartmann LC. Stratification of breast cancer risk in women with atypia: a Mayo cohort study. J Clin Oncol 2007; 25(19):2671-7.
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24. Gilbert JA, Goetz MP, Reynolds CA, Ingle JN, Giordano KF, Blair HE, Jenkins RB, Lingle WL, Reinholz MM, Adjei AA, Ames MA. Metaplastic breast carcinomas: Increased EGFR gene copy number via aneusomy. Breast Cancer Research and Treatment In Press 2007.
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25. Perez EA, Suman VJ, Davidson NE, Martino S, Kaufman PA, Lingle WL, Flynn PJ, Ingle JN, Visscher D, Jenkins RB. HER2 testing by local, central, and reference laboratories in specimens from the North Central Cancer Treatment Group N9831 intergroup adjuvant trial. J Clin Oncol 2006 Jul 1; 24(19):3032-8.
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26. Jones MB, Houwink AP, Freeman BK, Greenwood TM, Lafky JM, Lingle WL, Berchuck A, Maxwell GL, Podratz KC, Maihle NJ. The granulin-epithelin precursor is a steroid-regulated growth factor in endometrial cancer. J Soc Gynecol Investig 2006 May; 13(4):304-11.
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27. Holmes AL, Wise SS, Sandwick SJ, Lingle WL, Negron VC, Thompson WD, Wise JP Sr. Chronic exposure to lead chromate causes centrosome abnormalities and aneuploidy in human lung cells. Cancer Res 2006 Apr 15; 66(8):4041-8.
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28. Goetz MP, Suman VJ, Ingle JN, Nibbe AM, Visscher DW, Reynolds CA, Lingle WL, Erlander M, Ma XJ, Sgroi DC, Perez EA, Couch FJ. A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen. Clin Cancer Res 2006 Apr 1; 12(7 Pt 1):2080-7.
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29. Goetz MP, Knox SK, Suman VJ, Rae JM, Safgren SL, Ames MM, Visscher DW, Reynolds C, Couch FJ, Lingle WL, Weinshilboum RM, Fritcher EGB, Nibbe AM, Desta Z, Nguyen A, Flockhart DA, Perez EA, Ingle JN, 2006. The impact of cytochrome P450 2C6 metabolism in women receiving adjuvant tamoxifen. Breast Cancer Res Treat 2006 Jan; 101(1):113-121.
30. Goetz MP, Rae JM, Suman VJ, Safgren SL, Ames MM, Visscher DW, Reynolds C, Couch FJ, Lingle WL, Flockhart DA, Desta Z, Perez EA, Ingle JN. Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol 2005 Dec 20; 23(36):9312-8.
31. Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE, Davidson NE, Tan-Chiu E, Martino S, Paik S, Kaufman PA, Swain SM, Pisansky TM, Fehrenbacher L, Kutteh LA, Vogel VG, Visscher DW, Yothers G, Jenkins RB, Brown AM, Dakhil SR, Mamounas EP, Lingle WL, Klein P Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. New Engl J Med 2005 Oct 20; 353(16):1673-84.
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32. Kelemen LE, Sellers TA, Keeney GL, Lingle WL. Multivitamin and alcohol intake and folate receptor alpha expression in ovarian cancer. Cancer Epidemiol Biomarkers Prev 2005 Sep; 14(9):2168-72.
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33. Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K, Vierkant RA, Maloney SD, Pankratz VS, Hillman DW, Suman VJ, Johnson J, Blake C, Tlsty T, Vachon CM, Melton LJ 3rd, Visscher DW. Benign breast disease and the risk of breast cancer. N Engl J Med 2005 Jul 21; 353(3):229-37.
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34. Reinholz MM, Nibbe A, Jonart LM, Kitzmann K, Suman VJ, Ingle JN, Houghton R, Zehentner B, Roche PC, Lingle WL. Evaluation of a panel of tumor markers for molecular detection of circulating cancer cells in women with suspected breast cancer. Clin Cancer Res 2005 May 15; 11(10):3722-32.
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35. Lingle WL, Lukasiewicz K, Salisbury JL. Deregulation of the centrosome cycle and the origin of chromosomal instability in cancer. Adv Exp Med Biol 2005; 570:393-421.
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36. Li JJ, Weroha SJ, Lingle WL, Papa D, Salisbury JL, Li SA. Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACl rats. Proc Natl Acad Sci U S A 2004 Dec 28; 101(52):18123-8.
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37. Miller DV, Leontovich AA, Lingle WL, Suman VJ, Mertens ML, Lillie J, Ingalls KA, Perez EA, Ingle JN, Couch FJ, Visscher DW. Utilizing Nottingham prognostic index in microarray gene expression profiling of breast carcinomas. Mod Pathol 2004 Jul; 17(7):756-64.
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38. Mora GR, Olivier KR, Cheville JC, Mitchell RF, Lingle WL, Tindall DJ. The cytoskeleton differentially localizes the early growth response gene-1 protein in cancer and benign cells of the prostate. Mol Cancer Res 2004 Feb; 2(2):115-28.
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39. D'Assoro AB, Lingle WL, Salisbury JL. Centrosome amplification and the development of cancer. Oncogene 2002 Sep 9; 21(40):6146-53.
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40. D'Assoro AB, Barrett SL, Folk C, Negron VC, Boeneman K, Busby R, Whitehead C, Stivala F, Lingle WL, Salisbury JL. Amplified centrosomes in breast cancer: A potential indicator of tumor aggressiveness. Breast Cancer Research & Treatment 2002 Sep; 75(1):25-34.
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41. Lingle WL, Barrett SL, Negron VC, D'Assoro AB, Boeneman K, Liu WG, Whitehead CM, Reynolds C, Salisbury JL. Centrosome amplification drives chromosomal instability in breast tumor development. Proc Natl Acad Sci U S A 2002 Feb 19; 99(4):1978-83.
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42. Wang X, Babu JR, Harden JM, Jablonski SA, Gazi MH, Lingle WL, de Groen PC, Yen TJ, van Deursen JM. The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. J Biol Chem 2001 Jul 13; 276(28):26559-67.
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43. Lutz W, Lingle WL, McCormick D, Greenwood TM, Salisbury JL. Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication. J Biol Chem 2001 Jun 8; 276(23):20774-80.
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44. Lingle WL, Salisbury JL. Methods for the analysis of centrosome reproduction in cancer cells. Methods Cell Biol 2001; 67:325-336.
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45. Lingle WL, Salisbury JL. The role of the centrosome in the development of malignant tumors. Curr Top Dev Biol 2000; 49:313-29.
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46. Lingle WL, Salisbury JL. Altered centrosome structure is associated with abnormal mitoses in human breast tumors. Am J Pathol 1999 Dec; 155(6):1941-51.
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47. Salisbury JL, Lingle WL, White RA, Cordes LE, Barrett S. Microtubule nucleating capacity of centrosomes in tissue sections. Journal of Histochemistry & Cytochemistry 1999 Oct; 47(10):1265-74.
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48. Salisbury JL, Whitehead CM, Lingle WL, Barrett SL. Centrosomes and cancer. Biol Cell 1999 Jul; 91(6):451-60.
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49. Kumar R, Kobayashi T, Warner GM, Wu Y, Salisbury JL, Lingle W, Pittelkow MR. A novel immediate early response gene, IEX-1, is induced by ultraviolet radiation in human keratinocytes. Biochem Biophys Res Commun 1998 Dec 18; 253(2):336-41.
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50. Lingle WL, Lutz WH, Ingle JN, Maihle NJ, Salisbury JL. Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity. Proc Natl Acad Sci U S A 1998 Mar 17; 95(6):2950-5.
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51. McManus MJ, Lingle WL, Salisbury JL, Maihle NJ. A transformation-associated complex involving tyrosine kinase signal adapter proteins and caldesmon links v-erbB signaling to actin stress fiber disassembly. Proc Natl Acad Sci U S A 1997 Oct 14; 94(21):11351-6.
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52. McManus MJ, Lingle WL, Salisbury JL, Maihle NJ. A Shc-Grb2-Sos-caldesmon complex links oncogenic signaling to cytoskeletal regulatory processes. Proc Natl Acad Sci USA 1997; 94:11351-6.
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53. Lingle WL, Salisbury JL. Centrin and the cytoskeleton of the protist Holomastigotoides. Cell Motility & the Cytoskeleton 1997; 36(4):377-90.
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54. Newell SY, Porter D, Lingle WL. Lignocellulolysis by ascomycetes (fungi) of a saltmarsh grass (smooth cordgrass). Microscopy Research & Technique 1996 Jan 1; 33(1):32-46.
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55. Lingle WL, Salisbury JL. Ultrastructure of the parabasalid protist holomas-tigotoides. J Eukaryot Microbiol 1995 Sep-Oct; 42:490-505.
56. Ainley WM, McNeil KJ, Hill JW, Lingle WL, Simpson RB, Brenner ML, Nagao RT, Key JL. Regulatable endogenous production of cytokinins up to 'toxic' levels in transgenic plants and plant tissues. Plant Mol Biol 1993 Apr; 22(1):13-23.
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57. Roberts JK, Lingle WL, DeSimone N, Dure LS. Cellular concentrations and uniformity of cell-type accumulation of two Lea proteins in cotton embryos. Plant Cell 1993; 5:769-780.
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58. Lingle WL, Porter D, O'Kane DJ. Preliminary analysis of genetic complementation of bioluminescence in Panellus stypticus isolated from pine and hardwood. Mycologia 1992; 84:94-104.
59. Lingle WL, Clay RP, Porter D. TEM analysis of basidiosporogenesis in Panellus stypticus. Can J Bot 1992; 70:2017-2027.
60. Porter D, Lingle WL. Endolithic thraustochytrid marine fungi from planted shell fragments. Mycologia 1992; 84:289-299.
61. Lingle WL. Application of freeze substitution fixations for the study of biological samples. The Beam Newsletter of the Southeastern Electron Microscopy Society 1991; 7:10-16.
62. O'Kane DJ, Lingle WL, Porter D, Wampler JE. Localization of bioluminescent tissues during basidiocarp development in Panellus stypticus. Mycologia 1990; 82:595-605.
63. O'Kane DJ, Lingle WL, Porter D, Wampler JE. Spectral analysis of the bioluminescence of Panellus stypticus. Mycologia 1990; 82:606-615.
64. Porter D, Newell SY, Lingle WL. Tunneling bacteria in decaying leaves of the seagrass Thalassia testudinum. Aquatic Botany 1989; 35:395-401.
65. Lingle WL. Enhanced staining of the Basidiomycete Panellus stypticus. Cryptogam Bot 1989; 1:236-242.
66. O'Kane DJ, Lingle WL, Wampler JE, Legocki RP, Legocki M, Szalay AA. Visualization of bioluminescence as a marker of gene expression in Rhizobium-infected soybean root nodules. Plant Mol Biol 1988; 10:387-399.
67. Mansfield MA, Lingle WL, Key JL. The effects of lethal HS on nonadapted and thermotolerant root cells of Glycine max. J Ultrastruct Mol Struct Res 1988; 99:96-105.
68. O'Kane DJ, Lingle WL, Wampler JE, Legocki M, Legocki RP, Szalay A. Visualization of bioluminescence as a marker of gene expression in rhizobium-infected soybean root nodules. Plant Molecular Biology 1987; 10:387-99.
69. Rigsby WE, Lingle WL, O'Kane DJ, Lee J. Examination of penetrable volumes ('pores') in a high performance size exclusion chromatography matrix. Proc Elec Microscope Soc Amer 1985; 43:386-387.
70. Barstow WE, Lingle WL, Lovett JE. Observations on tubular smooth endoplasmic reticulum in the aquatic fungi Blastocladiella emersonii, Blastocladiella Britannica, and Catenaria anguillulae. J Ultrastruct Res 1985; 93:168-178.
71. Aldrich HC, Barstow WE, Lingle WL. Elemental analysis of particles in fungal zoospores. Arch Microbiol 1984; 139:102-104.
72. Lingle WL, Barstow WE. Ultrastructure of the zoospore of Blastocladia ramosa (Blastocladiales). Can J Bot 1983; 61:3502-3513.
73. Hartmann LC, Keeney GL, Lingle WL, Christianson TJH, Varghese B, Hillman D, Oberg AL, Low PS. Folate Receptor Overexpression is Associated with Poor Outcome in Breast Cancer. International Journal of Cancer. In Press. 2007.
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