Publications - Cynthia J . Wetmore, M.D., Ph.D.

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1. Jicha GA, Glantz J, Clarke MJ, Lehwald LM, Russo DP, Giannini C, Wald JT, Uhm J, Kumar N, Aksamit AJ, Wetmore CJ. Primary diffuse leptomeningeal gliomatosis. Eur Neurol 2009; 62(1):16-22.
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2. Jicha GA, Glantz J, Clarke MJ, Lehwald LM, Russo DP, Giannini C, Wald JT, Uhm J, Kumar N, Aksamit AJ, Wetmore CJ. Primary diffuse leptomeningeal gliomatosis. Eur Neurol 2009; 62(1):16-22. Epub 2009 May 04.
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3. Leonard JM, Ye H, Wetmore C, Karnitz LM. Sonic Hedgehog signaling impairs ionizing radiation-induced checkpoint activation and induces genomic instability. J Cell Biol 2008 Nov 3; 183(3):385-91. Epub 2008 Oct 27.
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4. Galvin KE, Ye H, Erstad DJ, Feddersen R, Wetmore C. Gli1 induces G2/M arrest and apoptosis in hippocampal but not tumor-derived neural stem cells. Stem Cells 2008 Apr; 26(4):1027-36. Epub 2008 Feb 14.
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5. Buckner JC, Brown PD, O'Neill BP, Meyer FB, Wetmore CJ, Uhm JH. Central nervous system tumors. Mayo Clin Proc 2007 Oct; 82(10):1271-86.
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6. Galvin KE, Ye H, Wetmore C. Differential gene induction by genetic and ligand-mediated activation of the Sonic hedgehog pathway in neural stem cells. Dev Biol 2007 Aug 15; 308(2):331-42. Epub 2007 May 31.
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7. Lee Y, Miller HL, Jensen P, Hernan R, Connelly M, Wetmore C, Zindy F, Roussel MF, Curran T, Gilbertson RJ, McKinnon PJ. A molecular fingerprint for medulloblastoma. Cancer Res 2003 Sep 1; 63(17):5428-37.
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8. Yang WQ, Senger D, Muzik H, Shi ZQ, Johnson D, Brasher PMA, Rewcastle NB, Hamilton M, Rutka J, Wolff J, Wetmore C, Curran T, Lee PWK, Forsyth PA. Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma. Cancer Res 2003 Jun 15; 63(12):3162-72.
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9. Wetmore C. Sonic hedgehog in normal and neoplastic proliferation: insight gained from human tumors and animal models. Current Opinion in Genetics & Development 2003 Feb; 13(1):34-42.
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10. Li L, Connelly MC, Wetmore C, Curran T, Morgan JI. Mouse embryos cloned from brain tumors. Cancer Research 2003; 63(11):2733-6.
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11. Karchewski LA, Gratto KA, Wetmore C, Verge VMK. Dynamic patterns of BDNF expression in injured sensory neurons: differential modulation by NGF and NT-3. Eur J Neurosci 2002 Oct; 16(8):1449-62.
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12. Weiss WA, Israel M, Cobbs C, Holland E, James CD, Louis DN, Marks C, McClatchey A, Roberts T, VanDyke T, Wetmore C, Chiu I, Giovannini M, Guha A, Higgins R, Mariono S, Radovanovic I, Reilly K, Adalpe K. Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum. Oncogene 2002; 21:7453-63.
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13. Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, McLaughlin ME, Kim JYH, Goumnerova LC, Black PM, Lau C, Allen JC, Zagzag D, Olson JM, Curran T, Wetmore C, Biegel JA, Poggio T, Mukherjee S, Califano A, Stolovitzky G, Louis DN, Mesirov JP, Lander E Prediction of central nervous system embryonal tumor outcome based on gene expression. Nature 2002; 415(6870):436-42.
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14. Gilbertson RJ, Bentley L, Hernan R, Junttila TT, Frant AJ, Haapasalo H, Connelly M, Wetmore C, Curran T, Elenius K, Ellison DW. ERBB Receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease. Clinical Cancer Research 2002; 8(10):3054-64.
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15. Wetmore C, Eberhart DE, Curran T. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 2001 Jan 15; 61(2):513-6.
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16. Wetmore C, Eberhart DE, Curran T. The normal patched allele is expressed in medulloblastomas from mice with heterozygous germline mutation of patched. Cancer Research 2000; 60(8):2239-46.
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17. Andersson H, Wetmore C, Lindqvist E, Luthman J, Olson L. Trimethyltin exposure in the rat induces delayed changes in brain-derived neurotrophic factor, fos and heat shock protein 70. Neurotoxicology 1997; 18(1):147-59.
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18. Schmidt-Kastner R, Humpel C, Wetmore C, Olson L. Cellular hybridization for BDNF, trkB and NGF mRNAs and BDNF-immunoreactivity in rat forebrain after pilocarpine-induced status epilepticus. Exp Brain Res 1996; 107:331-47.
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19. Schmidt-Kastner R, Wetmore C, Olson L. Comparative study of brain-derived neurotrophic factor mRNA and protein at the cellular level suggests multiple roles in hippocampus, striatum and cortex. Neuroscience 1996; 74:161-83.
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20. Wetmore C, Olson L. Neuronal and non-neuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia of rat suggest new intercellular trophic interactions. J Comp Neurol 1995; 353:143-59.
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21. Wetmore C, Olson L, Bean AJ. Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors. J Neurosci 1994; 14:1688-700.
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22. Humpel C, Giacobini MMJ, Wetmore C, Olson L. Brain-derived neurotrophic factor and trkB receptor mRNAs in grafts of cortex cerebri. Exp Neurol 1994; 127:171-7.
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23. Wetmore CJ, Cao Y, Pettersson RF, Olson L. Brain-derived neurotrophic factor (BDNF) peptide antibodies: characterization using a Vaccinia virus expression system. J Histochem Cytochem 1993; 41:521-33.
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24. Humpel C, Wetmore C, Olson L. Regulation of brain-derived neurotrophic factor messenger RNA and protein at the cellular level in pentylenetetrazol-induced epileptic seizures. Neuroscience 1993; 53:909-18.
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25. Wetmore C, Olson L. Expression and regulation of neurotrophins and their receptors in hippocampal systems. Hippocampus Spec No 1993; 3:171-81.
26. Schousboe A, Bachevalier J, Braak H, Heinemann U, Nitsch R, Schroder H, Wetmore C. Structural correlates and cellular mechanisms in entorhinal-hippocampal dysfunction. Hippocampus Spec No 1993; 3:293-301.
27. Meyer M, Matsuoka I, Wetmore C, Olson L, Thoenen H. Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA. J Cell Biol 1992; 119:45-54.
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28. Wetmore C, Bygdeman M, Olson L. High and low-affinity NGF receptor mRNAs in human foetal spinal cord and ganglia. Neuroreport 1992; 3:689-92.
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29. Freedman R, Strömberg I, Seiger A, Olson L, Nordstrom AL, Wiesel FA, Bygdeman M, Wetmore C. Palmer MR, Hoffer BJ. Initial studies of embryonic transplants of human hippocampus and cerebral cortex derived from schizophrenic women Biol Psychiatr 1992; 32:1148-63.
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30. Freedman R, Strömberg I, Seiger A, Olson L, Nordstrom AL, Wiesel FA, Bygdeman M, Wetmore C, Palmer MR, Hoffer BJ. Initial studies of embryonic transplants of human hippocampus and cerebral cortex derived from schizophrenic women. Biol Psychiatr 1992; 32:1148-63.
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31. Ebendal T, Söderstrom S, Hallböök F, Ernfors P, Ibanez, Persson H, Wetmore C, Strömberg I, Olson L. Human nerve growth factor: biological and immunological activities, and clinical possibilities in neurodegenerative disease. Adv Exp Med Biol 1991; 296:207-25.
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32. Wetmore C, Elde R. Detection and characterization of sensory microganglion associated with the spinal accessory nerve. J Comp Neurol 1991; 305:148-63.
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33. Wetmore C, Cao Y, Pettersson R, Olson L. Brain-derived neurotrophic factor: Subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies. Proc Natl Acad Sci 1991; 88:9843-7.
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34. Ernfors P, Wetmore C, Eriksdotter-Nilsson M, Bygdeman M, Stromberg I, Olson L, Persson H. The nerve growth factor receptor gene is expressed in both neuronal and non-neuronal tissues in the human fetus. Int J Dev Neurosci 1991; 9(1):57-66.
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35. Ernfors P, Wetmore C, Eriksdotter-Nilsson M, Bygdeman M, Strömberg I, Wetmore C, Olson L, Persson H. The nerve growth factor gene is expressed in both neuronal and non-neuronal tissues in the human embryo. Int J Dev Neurosci 1991; 9:57-66.
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36. Strömberg I, Wetmore CJ, Ebendal T, Ernfors P, Persson H, Olson L. Rescue of forebrain cholinergic neurons after implantation of genetically modified cells producing recombinant NGF. J Neurosci Res 1990; 25:405-11.
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37. Wetmore C, Ernfors P, Persson H, Olson L. Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization. Exp Neurol 1990; 109:141-52.
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38. Ernfors P, Wetmore C, Olson L, Persson H. Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family. Neuron 1990; 5:511-26.
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39. Freedman R, Wetmore C, Strömberg I, Leonard S, Olson L. Alpha-bungarotoxin binding to hippocampal interneurons: immunocytochemical characterization and effects on growth factor expression. J Neurosci 1993 75 1965-19; 13:1965-75.
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