Publications - Zhenkun Lou, Ph.D.

Back to Research Profile

1. Kim JE, Chen JJ, Lou Z. p30 DBC is a potential regulator of tumorigenesis. Cell Cycle 2009 Sep 15; 8(18):2933-6.
   View PubMed
2. Kim JE, Chen JJ, Lou Z. p30 DBC is a potential regulator of tumorigenesis. Cell Cycle 2009 Sep 15; 8(18):2933-6.
   View PubMed
3. Pei HD, Li L, Fridley BL, Jenkins GD, Kalari KR, Lingle W, Petersen G, Lou ZK, Wang LW. FKBP51 affects cancer cell response to chemotherapy by negatively regulating akt. Cancer Cell 2009 Sep 8; 16(3):259-66.
   View PubMed
4. Pei H, Li L, Fridley BL, Jenkins GD, Kalari KR, Lingle W, Petersen G, Lou Z, Wang L. FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell 2009 Sep 8; 16(3):259-66.
   View PubMed
5. Yuan J, Pu M, Zhang Z, Lou Z. Histone H3-K56 acetylation is important for genomic stability in mammals. Cell Cycle 2009 Jun 1; 8(11):1747-53. Epub 2009 Jun 03.
   View PubMed
6. Yuan J, Minter-Dykhouse K, Lou Z. A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. J Cell Biol 2009 Apr 20; 185(2):203-11. Epub 2009 Apr 13.
   View PubMed
7. Luo K, Lou Z. Dual roles of topoisomerase II. Cell Cycle 2009 Mar 9; 8(5). [Epub ahead of print]
   View PubMed
8. Clarke MJ, Mulligan EA, Grogan PT, Mladek AC, Carlson BL, Schroeder MA, Curtin NJ, Lou Z, Decker PA, Wu W, Plummer ER, Sarkaria JN. Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines. Mol Cancer Ther 2009 Feb; 8(2):407-14. Epub 2009 Jan 27.
   View PubMed
9. Luo K, Yuan J, Chen J, Lou Z. Topoisomerase IIalpha controls the decatenation checkpoint. Nat Cell Biol 2009 Feb; 11(2):204-10. Epub 2008 Dec 21.
   View PubMed
10. Arneson LN, Segovis CM, Gomez TS, Schoon RA, Dick CJ, Lou Z, Billadeau DD, Leibson PJ. Dynamin 2 regulates granule exocytosis during NK cell-mediated cytotoxicity. J Immunol 2008 Nov 15; 181(10):6995-7001.
    View PubMed
11. Wu L, Luo K, Lou Z, Chen J. MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci U S A 2008 Aug 12; 105(32):11200-5. Epub 2008 Aug 04.
    View PubMed
12. Wu L, Luo K, Lou Z, Chen J. MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci U S A 2008 Aug 12; 105(32):11200-5.
    View PubMed
13. Minter-Dykhouse K, Ward I, Huen MS, Chen J, Lou Z. Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis. J Cell Biol 2008 Jun 2; 181(5):727-35. Epub 2008 May 26.
    View PubMed
14. Kim JE, Chen J, Lou Z. DBC1 is a negative regulator of SIRT1. Nature 2008 Jan 31; 451(7178):583-6.
    View PubMed
15. Ahmed EA, van der Vaart A, Barten A, Kal HB, Chen J, Lou Z, Minter-Dykhouse K, Bartkova J, Bartek J, de Boer P, de Rooij DG. Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1. DNA Repair (Amst) 2007 Sep 1; 6(9):1243-54. Epub 2007 Mar 21.
    View PubMed
16. Huang H, Regan KM, Lou Z, Chen J, Tindall DJ. CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science 2006 Oct 13; 314(5797):294-7.
    View PubMed
17. Lou Z, Chen J. Cellular senescence and DNA repair. Exp Cell Res 2006 Aug 15; 312(14):2641-6. Epub 2006 Jun 20.
    View PubMed
18. Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell 2006 Jan 20; 21(2):201-14.
    View PubMed
19. Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell 2006 Jan 20; 21(2):187-200.
    View PubMed
20. Lou Z, Minter-Dykhouse K, Chen J. BRCA1 participates in DNA decatenation. Nat Struct Mol Biol 2005 Jul; 12(7):589-93.
    View PubMed
21. Lou Z, Chen BP, Asaithamby A, Minter-Dykhouse K, Chen DJ, Chen J. MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. J Biol Chem 2004 Nov 5; 279(45):46359-62. Epub 2004 Sep 17.
    View PubMed
22. Lou Z, Chen J. BRCA proteins and DNA damage checkpoints. Front Biosci 2003 May 1; 8:s718-21. Epub 2003 May 01.
    View PubMed
23. Lou Z, Chini CC, Minter-Dykhouse K, Chen JJ. Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. J Biol Chem 2003 Apr 18; 278(16):13599-602. Epub 2003 Feb 27.
    View PubMed
24. Lou Z, Minter-Dykhouse K, Wu X, Chen J. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature 2003 Feb 27; 421(6926):957-61.
    View PubMed
25. Lou Z, Chini C, Minter-Dykhouse K, Chen J. MDC1 regulates BRCA1 relocalization and phosphorylation in DNA damage checkpoint. J Biol Chem 2003; 278:13599-603.
    View PubMed
26. Lou Z, Billadeau DD, Savoy DN, Schoon RA, Leibson PJ. A role for a RhoA/ROCK/LIM-kinase pathway in the regulation of cytotoxic lymphocytes. J Immunol 2001 Nov 15; 167(10):5749-57.
    View PubMed
27. Lou Z, Jevremovic D, Billadeau DD, Leibson PJ. A balance between positive and negative signals in cytotoxic lymphocytes regulates the polarization of lipid rafts during the development of cell-mediated killing. J Exp Med 2000 Jan 17; 191(2):347-54.
    View PubMed