Publications - Gregory A. Worrell, M.D., Ph.D.

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  1. Bower MR, Stead M, Van Gompel JJ, Bower RS, Sulc V, Asirvatham SJ, Worrell GA. Intravenous recording of intracranial, broadband EEG. J Neurosci Methods. 2013 Mar 30; 214(1):21-6. Epub 2013 Jan 08.
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  2. Van Gompel JJ, Ottman R, Worrell GA, Marsh R, Wetjen NM, Cascino GD, Meyer FB. Use of anterior temporal lobectomy for epilepsy in a community-based population. Arch Neurol. 2012 Nov; 69(11):1476-81.
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  3. Lu Y, Yang L, Worrell GA, Brinkmann B, Nelson C, He B. Dynamic imaging of seizure activity in pediatric epilepsy patients. Clin Neurophysiol. 2012 Nov; 123(11):2122-9. Epub 2012 May 18.
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  4. Yang L, Worrell GA, Nelson C, Brinkmann B, He B. Spectral and spatial shifts of post-ictal slow waves in temporal lobe seizures. Brain. 2012 Oct; 135(Pt 10):3134-43. Epub 2012 Aug 24.
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  5. Worrell GA, Jerbi K, Kobayashi K, Lina JM, Zelmann R, Le Van Quyen M. Recording and analysis techniques for high-frequency oscillations. Prog Neurobiol. 2012 Sep; 98(3):265-78. Epub 2012 Mar 07.
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  6. Lu Y, Yang L, Worrell GA, He B. Seizure source imaging by means of FINE spatio-temporal dipole localization and directed transfer function in partial epilepsy patients. Clin Neurophysiol. 2012 Jul; 123(7):1275-83. Epub 2011 Dec 14.
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  7. Wass CT, Warner ME, Worrell GA, Castagno JA, Howe M, Kerber KA, Palzkill JM, Schroeder DR, Cascino GD. Effect of general anesthesia in patients with cerebral palsy at the turn of the new millennium: a population-based study evaluating perioperative outcome and brief overview of anesthetic implications of this coexisting disease. J Child Neurol. 2012 Jul; 27(7):859-66. Epub 2011 Dec 21.
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  8. Bower MR, Stead M, Meyer FB, Marsh WR, Worrell GA. Spatiotemporal neuronal correlates of seizure generation in focal epilepsy. Epilepsia. 2012 May; 53(5):807-16. Epub 2012 Feb 21.
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  9. Quek AM, Britton JW, McKeon A, So E, Lennon VA, Shin C, Klein C, Watson RE Jr, Kotsenas AL, Lagerlund TD, Cascino GD, Worrell GA, Wirrell EC, Nickels KC, Aksamit AJ, Noe KH, Pittock SJ. Autoimmune epilepsy: clinical characteristics and response to immunotherapy. Arch Neurol. 2012 May; 69(5):582-93.
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  10. Brinkmann BH, Jones DT, Stead M, Kazemi N, O'Brien TJ, So EL, Blumenfeld H, Mullan BP, Worrell GA. Statistical parametric mapping demonstrates asymmetric uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in normal brain. J Cereb Blood Flow Metab. 2012 Jan; 32(1):190-8. Epub 2011 Sep 21.
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  11. Zakaria T, Noe K, So E, Cascino GD, Wetjen N, Van Gompel JJ, Marsh WR, Meyer FB, Giannini C, Watson RE, Worrell GA. Scalp and intracranial EEG in medically intractable extratemporal epilepsy with normal MRI. ISRN Neurol. 2012; 2012:942849. Epub 2012 Jun 25.
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  12. Lu Y, Yang L, Worrell GA, Brinkmann B, Nelson C, He B. Dynamic seizure imaging in patients with extratemporal lobe epilepsy. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2012; 6228-31.
  13. Mullen T, Worrell G, Makeig S. Multivariate principal oscillation pattern analysis of ICA sources during seizure. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2012; 2921-4.
  14. Blanco JA, Stead M, Krieger A, Stacey W, Maus D, Marsh E, Viventi J, Lee KH, Marsh R, Litt B, Worrell GA. Data mining neocortical high-frequency oscillations in epilepsy and controls. Brain. 2011 Oct; 134(Pt 10):2948-59. Epub 2011 Sep 08.
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  15. Worrell G, Gotman J. High-frequency oscillations and other electrophysiological biomarkers of epilepsy: clinical studies. Biomark Med. 2011 Oct; 5(5):557-66.
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  16. Morrell MJ, RNS System in Epilepsy Study Group. Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology. 2011 Sep 27; 77(13):1295-304. Epub 2011 Sep 14.
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  17. Davis KA, Sturges BK, Vite CH, Ruedebusch V, Worrell G, Gardner AB, Leyde K, Sheffield WD, Litt B. A novel implanted device to wirelessly record and analyze continuous intracranial canine EEG. Epilepsy Res. 2011 Sep; 96(1-2):116-22. Epub 2011 Jun 14.
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  18. Yang L, Wilke C, Brinkmann B, Worrell GA, He B. Dynamic imaging of ictal oscillations using non-invasive high-resolution EEG. Neuroimage. 2011 Jun 15; 56(4):1908-17. Epub 2011 Mar 29.
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  19. Hu S, Dai G, Worrell GA, Dai Q, Liang H. Causality analysis of neural connectivity: critical examination of existing methods and advances of new methods. IEEE Trans Neural Netw. 2011 Jun; 22(6):829-44. Epub 2011 Apr 19.
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  20. Van Gompel JJ, Bower MR, Worrell GA, Stead M, Meier TR, Goerss SJ, Chang SY, Kim I, Meyer FB, Richard Marsh W, Marsh MP, Lee KH. Swine model for translational research of invasive intracranial monitoring. Epilepsia. 2011 Jun; 52(6):e49-53. Epub 2011 May 31.
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  21. Wang G, Worrell G, Yang L, Wilke C, He B. Interictal spike analysis of high-density EEG in patients with partial epilepsy. Clin Neurophysiol. 2011 Jun; 122(6):1098-105. Epub 2010 Dec 03.
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  22. Iasemidis LD, Schachter S, Worrell GA, Mogul D. Dynamics and neuromodulation of the epileptic brain. Introduction. Int J Neural Syst. 2011 Apr; 21(2):v-vi.
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  23. Van Gompel JJ, Koeller KK, Meyer FB, Marsh WR, Burger PC, Roncaroli F, Worrell GA, Giannini C. Cortical ependymoma: an unusual epileptogenic lesion. J Neurosurg. 2011 Apr; 114(4):1187-94. Epub 2011 Jan 14.
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  24. Wilke C, Worrell G, He B. Graph analysis of epileptogenic networks in human partial epilepsy. Epilepsia. 2011 Jan; 52(1):84-93. Epub 2010 Dec 03.
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  25. Wass CT, Warner ME, Worrell GA, Castagno J, Howe M, Kerber K, Palzkill JM, Schroeder DR, Cascino GD. The effect of general anesthesia in cerebral palsy patients at the turn of the millinium: A population-based study evaluating perioperative outcome and brief overview of anesthetic implications of this co-existing disease. Journal of Child Neurology. 2011 (In Press).
  26. Mullen T, Acar ZA, Worrell G, Makeig S. Modeling cortical source dynamics and interactions during seizure. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2011; 1411-4.
  27. Acar ZA, Palmer J, Worrell G, Makeig S. Electrocortical source imaging of intracranial EEG data in epilepsy. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2011; 3909-12.
  28. Yang L, Wilke C, Brinkmann B, Worrell GA, He B. Dynamic imaging of ictal rhythmic activity using dense-array EEG. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2011; 8271-4.
  29. Hsu D, Hsu M, Grabenstatter HL, Worrell GA, Sutula TP. Time-frequency analysis using damped-oscillator pseudo-wavelets: Application to electrophysiological recordings. J Neurosci Methods. 2010 Dec 15; 194(1):179-92. Epub 2010 Oct 07.
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  30. Lam EM, Worrell GA, Laughlin RS. Semiology of the rare seizure subtype piloerection. Arch Neurol. 2010 Dec; 67(12):1524-7.
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  31. Warren CP, Hu S, Stead M, Brinkmann BH, Bower MR, Worrell GA. Synchrony in normal and focal epileptic brain: the seizure onset zone is functionally disconnected. J Neurophysiol. 2010 Dec; 104(6):3530-9. Epub 2010 Oct 06.
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  32. Koby DG, Zirakzadeh A, Staab JP, Seime R, Cha SS, Nelson CL, Sengem S, Berge R, Marshall EA, Varner JE, Vickers KS, Trenerry MR, Worrell GA. Questioning the role of abuse in behavioral spells and epilepsy. Epilepsy Behav. 2010 Dec; 19(4):584-90. Epub 2010 Oct 20.
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  33. Whitmer D, Worrell G, Stead M, Lee IK, Makeig S. Utility of independent component analysis for interpretation of intracranial EEG. Frontiers in Human Neuroscience. 2010 Nov; 4.
  34. Blanco JA, Stead M, Krieger A, Viventi J, Marsh WR, Lee KH, Worrell GA, Litt B. Unsupervised classification of high-frequency oscillations in human neocortical epilepsy and control patients. J Neurophysiol. 2010 Nov; 104(5):2900-12. Epub 2010 Sep 01.
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  35. Hu S, Stead M, Dai Q, Worrell GA. On the recording reference contribution to EEG correlation, phase synchrony, and coherence. IEEE Trans Syst Man Cybern B Cybern. 2010 Oct; 40(5):1294-304. Epub 2010 Jan 26.
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  36. Van Gompel JJ, Marsh WR, Meyer FB, Worrell GA. Patient-assessed satisfaction and outcome after microsurgical resection of cavernomas causing epilepsy. Neurosurg Focus. 2010 Sep; 29(3):E16.
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  37. Stead M, Bower M, Brinkmann BH, Lee K, Marsh WR, Meyer FB, Litt B, Van Gompel J, Worrell GA. Microseizures and the spatiotemporal scales of human partial epilepsy. Brain. 2010 Sep; 133(9):2789-97. Epub 2010 Aug 04.
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  38. Frei MG, Zaveri HP, Arthurs S, Bergey GK, Jouny CC, Lehnertz K, Gotman J, Osorio I, Netoff TI, Freeman WJ, Jefferys J, Worrell G, Quyen Mle V, Schiff SJ, Mormann F. Controversies in epilepsy: debates held during the Fourth International Workshop on Seizure Prediction. Epilepsy Behav. 2010 Sep; 19(1):4-16. Epub 2010 Aug 13.
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  39. Van Gompel JJ, Meyer FB, Marsh WR, Lee KH, Worrell GA. Stereotactic electroencephalography with temporal grid and mesial temporal depth electrode coverage: does technique of depth electrode placement affect outcome? J Neurosurg. 2010 Jul; 113(1):32-8.
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  40. Kazemi NJ, Worrell GA, Stead SM, Brinkmann BH, Mullan BP, O'Brien TJ, So EL. Ictal SPECT statistical parametric mapping in temporal lobe epilepsy surgery. Neurology. 2010 Jan 5; 74(1):70-6.
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  41. Benish SM, Cascino GD, Warner ME, Worrell GA, Wass CT. Effect of general anesthesia in patients with epilepsy: a population-based study. Epilepsy Behav. 2010 Jan; 17(1):87-9. Epub 2009 Nov 11.
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  42. Bell ML, Rao S, So EL, Trenerry M, Kazemi N, Stead SM, Cascino G, Marsh R, Meyer FB, Watson RE, Giannini C, Worrell GA. Epilepsy surgery outcomes in temporal lobe epilepsy with a normal MRI. Epilepsia. 2009 Sep; 50(9):2053-60. Epub 2009 Apr 06.
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  43. Wetjen NM, Marsh WR, Meyer FB, Cascino GD, So E, Britton JW, Stead SM, Worrell GA. Intracranial electroencephalography seizure onset patterns and surgical outcomes in nonlesional extratemporal epilepsy. J Neurosurg. 2009 Jun; 110(6):1147-52.
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  44. Van Gompel JJ, Rubio J, Cascino GD, Worrell GA, Meyer FB. Electrocorticography-guided resection of temporal cavernoma: is electrocorticography warranted and does it alter the surgical approach? J Neurosurg. 2009 Jun; 110(6):1179-85.
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  45. Brinkmann BH, Bower MR, Stengel KA, Worrell GA, Stead M. Large-scale electrophysiology: acquisition, compression, encryption, and storage of big data. J Neurosci Methods. 2009 May 30; 180(1):185-92. Epub 2009 Apr 01.
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  46. Bower MR, Stead M, Brinkmann BH, Dufendach K, Worrell GA. Metadata and annotations for multi-scale electrophysiological data. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:2811-4.
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  47. Brinkmann BH, Bower MR, Stengel KA, Worrell GA, Stead M. Multiscale electrophysiology format: an open-source electrophysiology format using data compression, encryption, and cyclic redundancy check. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:7083-6.
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  48. Wang G, Yang L, Worrell G, He B. The relationship between conductivity uncertainties and EEG source localization accuracy. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC. 2009 2009; 4799-802.
  49. Wilke C, Worrell GA, He B. Analysis of epileptogenic network properties during ictal activity. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC. 2009 2009; 2220-3.
  50. Acar ZA, Worrell G, Makeig S. Patch-basis electrocortical source imaging in epilepsy. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC. 2009 2009; 2930-3.
  51. Tan KM, Britton JW, Buchhalter JR, Worrell GA, Lagerlund TD, Shin C, Cascino GD, Meyer FB, So EL. Influence of subtraction ictal SPECT on surgical management in focal epilepsy of indeterminate localization: a prospective study. Epilepsy Res. 2008 Dec; 82(2-3):190-3. Epub 2008 Oct 01.
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  52. Van Gompel JJ, Stead SM, Giannini C, Meyer FB, Marsh WR, Fountain T, So E, Cohen-Gadol A, Lee KH, Worrell GA. Phase I trial: safety and feasibility of intracranial electroencephalography using hybrid subdural electrodes containing macro- and microelectrode arrays. Neurosurg Focus. 2008 Sep; 25(3):E23.
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  53. Van Gompel JJ, Worrell GA, Bell ML, Patrick TA, Cascino GD, Raffel C, Marsh WR, Meyer FB. Intracranial electroencephalography with subdural grid electrodes: techniques, complications, and outcomes. Neurosurgery. 2008 Sep; 63(3):498-505; discussion 505-6.
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  54. Worrell GA, Gardner AB, Stead SM, Hu S, Goerss S, Cascino GJ, Meyer FB, Marsh R, Litt B. High-frequency oscillations in human temporal lobe: simultaneous microwire and clinical macroelectrode recordings. Brain. 2008 Apr; 131(Pt 4):928-37. Epub 2008 Feb 07.
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  55. Acar ZA, Makeig S, Worrell GA. Head modeling and cortical source localization in epilepsy. Conf Proc IEEE Eng Med Biol Soc 19163530 2008; 20083763-6. PubMed PMID:3763-6.
  56. Hu S, Stead M, Worrell GA. Removal of scalp reference signal and line noise for intracranial EEGs. IEEE International Conference on Networking, Sensing and Control, 2008:1486-91.
  57. Worrell GA, Stead M, Cascino GD. Electrocorticography. Handbook of Clinical Neurophysiology. 2008; 8(C):141-9.
  58. Firpi H, Smart O, Worrell G, Marsh E, Dlugos D, Litt B. High-frequency oscillations detected in epileptic networks using swarmed neural-network features. Ann Biomed Eng. 2007 Sep; 35(9):1573-84. Epub 2007 Jun 01.
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  59. Hu S, Stead M, Worrell GA. Automatic identification and removal of scalp reference signal for intracranial EEGs based on independent component analysis. IEEE Trans Biomed Eng. 2007 Sep; 54(9):1560-72.
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  60. Gardner AB, Worrell GA, Marsh E, Dlugos D, Litt B. Human and automated detection of high-frequency oscillations in clinical intracranial EEG recordings. Clin Neurophysiol. 2007 May; 118(5):1134-43.
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  61. Tan KM, Worrell GA, Parisi JE, Lachance DH. Creutzfeldt-Jakob disease with focal electroencephalographic and magnetic resonance imaging findings. Arch Neurol. 2007 Apr; 64(4):600-1.
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  62. Ding L, Worrell GA, Lagerlund TD, He B. Ictal source analysis: localization and imaging of causal interactions in humans. Neuroimage. 2007 Jan 15; 34(2):575-86. Epub 2006 Nov 16.
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  63. Hu S, Stead SM, Gardner A, Worrell GA. The Effect of Recording Reference on EEG: Phase Synchrony and Coherence. Lecture Notes in Computer Science-Advances in Neural Networks. 2007:73-1280.
  64. Ding L, Worrell GA, Lagerlund TD, He B. 3D source localization of interictal spikes in epilepsy patients with MRI lesions. Phys Med Biol. 2006 Aug 21; 51(16):4047-62. Epub 2006 Aug 02.
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  65. D'Alessandro M, Vachtsevanos G, Esteller R, Echauz J, Cranstoun S, Worrell G, Parish L, Litt B. A multi-feature and multi-channel univariate selection process for seizure prediction. Clin Neurophysiol. 2005 Mar; 116(3):506-16.
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  66. Esteller R, Echauz J, D'Alessandro M, Worrell G, Cranstoun S, Vachtsevanos G, Litt B. Continuous energy variation during the seizure cycle: towards an on-line accumulated energy. Clin Neurophysiol. 2005 Mar; 116(3):517-26.
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  67. Stead M, Worrell GA, Litt B. Frequency and dependence of long range temporal correlations in human hippocampal energy fluctuations. Complexity. 2005; 10(5):35-44.
  68. Worrell GA, Parish L, Cranstoun SD, Jonas R, Baltuch G, Litt B. High-frequency oscillations and seizure generation in neocortical epilepsy. Brain. 2004 Jul; 127(Part 7):1496-506.
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  69. Vadlamudi L, So EL, Worrell GA, Mosewich RK, Cascino GD, Meyer FB, Lesnick TG. Factors underlying scalp-EEG interictal epileptiform discharges in intractable frontal lobe epilepsy. Epileptic Disorders. 2004 Jun; 6(2):89-95.
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  70. Cohen-Gadol AA, Britton JW, Worrell GA, Meyer FB. Transient cortical abnormalities on magnetic resonance imaging after status epilepticus: case report. Surg Neurol. 2004 May; 61(5):479-82; discussion 482.
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  71. Parish LM, Worrell GA, Cranstoun SD, Stead SM, Pennell P, Litt B. Long-range temporal correlations in epileptogenic and non-epileptogenic human hippocampus. Neuroscience. 2004; 125(4):1069-76.
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  72. Cambier DM, Kantarci K, Worrell GA, Westmoreland BF, Aksamit AJ. Lateralized and focal clinical, EEG, and FLAIR MRI abnormalities in Creutzfeldt-Jakob disease. Clin Neurophysiol. 2003 Sep; 114(9):1724-8.
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  73. Worrell GA, Cranstoun SD, Echauz J, Litt B. Evidence for self-organized criticality in human epileptic hippocampus. Neuroreport. 2002 Nov 15; 13(16):2017-21.
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  74. Worrell GA, Lagerlund TD, Buchhalter JR. Role and limitations of routine and ambulatory scalp electroencephalography in diagnosing and managing seizures. Mayo Clin Proc. 2002 Sep; 77(9):991-8.
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  75. Worrell GA, Sencakova D, Jack CR, Flemming KD, Fulgham JR, So EL. Rapidly progressive hippocampal atrophy: Evidence for a seizure-induced mechanism. Neurology. 2002 May 28; 58(10):1553-6.
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  76. Worrell GA, Fleming K, Fulgham JR, So EL. Hippocampal atrophy secondary to complex partial seizures initiated by an acute extratemporal focus. Neurology. 2002 May 28; 58(10):1553-6.
  77. Worrell GA, So EL, Kazemi J, O'Brien TJ, Mosewich RK, Cascino GD, Meyer FB, Marsh WR. Focal ictal beta discharge on scalp EEG predicts excellent outcome of frontal lobe epilepsy surgery. Epilepsia. 2002 Mar; 43(3):277-82.
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  78. Worrell GA, Wijdicks EF, Eggers SD, Phan T, Damario MA, Mullany CJ. Ovarian hyperstimulation syndrome with ischemic stroke due to an intracardiac thrombus. Neurology. 2001 Oct 9; 57(7):1342-4.
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  79. Nahab FB, Worrell GA, Weinshenker BG. 25-year-old man with recurring headache and confusion. Mayo Clin Proc. 2001 Jan; 76(1):75-8.
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  80. Phan TG, Wijdicks EF, Worrell GA, Fulgham JR. False subarachnoid hemorrhage in anoxic encephalopathy with brain swelling. J Neuroimaging. 2000 Oct; 10(4):236-8.
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  81. Worrell GA, Lagerlund TD, Sharbrough FW, Brinkmann BH, Busacker NE, Cicora KM, O'Brien TJ. Localization of the epileptic focus by low-resolution electromagnetic tomography in patients with a lesion demonstrated by MRI. Brain Topogr. 2000 Summer; 12(4):273-82.
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  82. Worrell GA, Buchhalter JR, McBride KL. Lyme disease and pseudotumor. Mayo Clinc Prceedings. 2000; 75(3):315.
  83. Worrell GA, McBride KL, Buchhalter JR. 14-year-old boy with blurred vision and diplopia. Mayo Clin Proc. 1999 Nov; 74(11):1157-60.
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  84. Worrell GA, Miller BN, Reese TL. Virial expansion of a quantum particle in a classical gas: Application to the orthopositronium decay rate. Phys Rev A. 1996 Apr; 53(4):2101-7.
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  85. Miller BN, Reese TL, Worrell GA. Viral expansion of the positron and positronium decay rate in a dilute gas: The linear contribution. Canadian Journal of Physics. 1996; 74:548-53.
  86. Miller BN, Chen J, Reese TL, Worrell GA. Path-Integral Studies of Positrons and Positronium in Fluids. Journal de Physique IV. 1993; C4(3):31-9.
  87. Worrell GA, Matulich A, Miller BN. Dynamics in a Discontinuous Field. Chaos. 1993; 3:397.
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  88. Miller BN, Worrell GA, Reese T. Positron Life-time Distributions in Fluids. Physical Review E. 1993; 47:4083.
  89. Worrell GA, Miller BN. Positron annihilation in xenon: The path-integral approach. Phys Rev A. 1992 Sep 15; 46(6):3380-9.
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