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Publications - Adrian Vella, M.D.

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  1. Papathanasopoulos A, Camilleri M, Carlson PJ, Vella A, Nord SJ, Burton DD, Odunsi ST, Zinsmeister AR. A Preliminary Candidate Genotype-Intermediate Phenotype Study of Satiation and Gastric Motor Function in Obesity. Obesity (Silver Spring) 2009 Oct 29. [Epub ahead of print]
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  2. Erickson D, Erickson B, Watson R, Patton A, Atkinson J, Meyer F, Nippoldt T, Carpenter P, Natt N, Vella A, Thapa P. 3 Tesla magnetic resonance imaging with and without corticotropin releasing hormone stimulation for the detection of microadenomas in Cushing's syndrome. Clin Endocrinol (Oxf) 2009 Oct 07. [Epub ahead of print]
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  3. Vella A, Rizza RA. Application of isotopic techniques using constant specific activity or enrichment to the study of carbohydrate metabolism. Diabetes 2009 Oct; 58(10):2168-74.
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  4. Sathananthan A, Vella A. Personalized pharmacotherapy for Type 2 diabetes mellitus. Pers. Med 2009 Jul; 6(4):417-22.
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  5. Brown DL, Henrichsen TL, Clayton AC, Hudson SB, Coddington CC 3rd, Vella A. Ovarian stromal hyperthecosis: sonographic features and histologic associations. J Ultrasound Med 2009 May; 28(5):587-93.
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  6. Placzkowski KA, Vella A, Thompson GB, Grant CS, Reading CC, Charboneau JW, Andrews JC, Lloyd RV, Service FJ. Secular trends in the presentation and management of functioning insulinoma at the Mayo Clinic, 1987-2007. J Clin Endocrinol Metab 2009 Apr; 94(4):1069-73. Epub 2009 Jan 13.
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  7. Rumilla KM, Erickson LA, Service FJ, Vella A, Thompson GB, Grant CS, Lloyd RV. Hyperinsulinemic hypoglycemia with nesidioblastosis: histologic features and growth factor expression. Mod Pathol 2009 Feb; 22(2):239-45. Epub 2008 Oct 17.
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  8. Dalla Man C, Bock G, Giesler PD, Serra DB, Ligueros-Saylan M, Foley JE, Camilleri M, Toffolo G, Cobelli C, Rizza RA, Vella A. The effect of Dipeptidyl Peptidase 4 Inhibition on Insulin Secretion and Action in Type 2 Diabetes. Diabetes Care Jan. 2009; 1(14-8).
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  9. Dalla Man C, Bock G, Giesler PD, Serra DB, Ligueros Saylan M, Foley JE, Camilleri M, Toffolo G, Cobelli C, Rizza RA, Vella A. Dipeptidyl peptidase-4 inhibition by vildagliptin and the effect on insulin secretion and action in response to meal ingestion in type 2 diabetes. Diabetes Care 2009 Jan; 32(1):14-8. Epub 2008 Oct 17.
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  10. Arruda-Olson AM, Patch RK 3rd, Leibson CL, Vella A, Frye RL, Weston SA, Killian JM, Roger VL. Effect of second-generation sulfonylureas on survival in patients with diabetes mellitus after myocardial infarction. Mayo Clin Proc 2009; 84(1):28-33.
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  11. Arruda-Olson AM, Patch RK, Leibson CL, Vella A, Frye RL, Weston SA, Killian JM, Roger VL. Diabetes mellitus and death after myocardial infarction: experience of the community. Mayo Clin Proc 2009; 84(1):285-33.
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  12. Vella A, Thompson GB, Service FJ. Diagnosis and management of hyperinsulinemic hypolgycemia. In: 2009:493-506.
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  13. Vella A, Bock G, Giesler PD, Burton DB, Serra DB, Saylan ML, Deacon CF, Foley JE, Rizza RA, Camilleri M. The effect of dipeptidyl peptidase-4 inhibition on gastric volume, satiation and enteroendocrine secretion in type 2 diabetes: a double-blind, placebo-controlled crossover study. Clin Endocrinol (Oxf) 2008 Nov; 69(5):737-44. Epub 2008 Mar 10.
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  14. Vella A, Shah P, Basu A, Rizza RA. Prandial insulin and the systemic appearance of meal-derived glucose in people with type 1 diabetes. Diabetes Care 2008 Nov; 31(11):2230-1.
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  15. Rumilla KM, Erickson LA, Service FJ, Vella A, Thompson GB, Grant CS, Lloyd RV. Hyperinsulinemic hypoglycemia with nesidioblastosis: histologic features and growth factor expression. Mod Pathol 2008 Oct 17.
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  16. Roberts RO, Geda YE, Knopman DS, Christianson TJ, Pankratz VS, Boeve BF, Vella A, Rocca WA, Petersen RC. Association of duration and severity of diabetes mellitus with mild cognitive impairment. Arch Neurol 2008 Aug; 65(8):1066-73.
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  17. Szarka LA, Camilleri M, Vella A, Burton D, Baxter K, Simonson J, Zinsmeister AR. A stable isotope breath test with a standard meal for abnormal gastric emptying of solids in the clinic and in research. Clin Gastroenterol Hepatol 2008 Jun; 6(6):635-643.e1. Epub 2008 Apr 14.
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  18. Vella A, Camilleri M. Pharmacogenetics: potential role in the treatment of diabetes and obesity. Expert Opin Pharmacother 2008 May; 9(7):1109-19.
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  19. Atkinson JL, Young WF Jr, Meyer FB, Davis DH, Nippoldt TB, Erickson D, Vella A, Natt N, Abboud CF, Carpenter PC. Sublabial transseptal vs transnasal combined endoscopic microsurgery in patients with Cushing disease and MRI-depicted microadenomas. Mayo Clin Proc 2008 May; 83(5):550-3.
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  20. Porterfield JR, Thompson GB, Young WF Jr, Chow JT, Fryrear RS, van Heerden JA, Farley DR, Atkinson JL, Meyer FB, Abboud CF, Nippoldt TB, Natt N, Erickson D, Vella A, Carpenter PC, Richards M, Carney JA, Larson D, Schleck C, Churchward M, Grant CS. Surgery for Cushing's syndrome: an historical review and recent ten-year experience. World J Surg 2008 May; 32(5):659-77.
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  21. Young WF Jr, du Plessis H, Thompson GB, Grant CS, Farley DR, Richards ML, Erickson D, Vella A, Stanson AW, Carney JA, Abboud CF, Carpenter PC. The clinical conundrum of corticotropin-independent autonomous cortisol secretion in patients with bilateral adrenal masses. World J Surg 2008 May; 32(5):856-62.
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  22. Vella A, Bouatia-Naji N, Heude B, Cooper JD, Lowe CE, Petry C, Ring SM, Dunger DB, Todd JA, Ong KK. Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes. Diabetologia 2008 May; 51(5):811-5. Epub 2008 Mar 04.
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  23. Vella A, Bock G, Giesler PD, Burton DB, Serra DB, Saylan ML, Deacon CF, Foley JE, Rizza RA, Camilleri M. The effect of dipeptidyl peptidase 4 inhibition on gastric volume, satiation and enteroendocrine secretion in type 2 diabetes: a double blind, placebo-controlled crossover study. Clin Endocrinol 2008; 69:737-744.
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  24. Cooper JD, Smyth DJ, Bailey R, Payne F, Downes K, Godfrey LM, Masters J, Zeitels LR, Vella A, Walker NM, Todd JA. The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes - art. no. 71. BMC Medical Genetics 2007 Nov 28; 8:71.
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  25. Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JH, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007 Jul; 39(7):857-64 Epub 2007 Jun 6.
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  26. Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JHM, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy Robust Associations of Four New Chromosome Regions from Genome-wide Analyses of Type 1 Diabetes. Nature Genetics 2007 Jul; 39(7):857-64.
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  27. Vella A, Bock G, Giesler PD, Burton DB, Serra DB, Saylan ML, Dunning BE, Foley JE, Rizza RA, Camilleri M. Effects of dipeptidyl peptidase-4 inhibition on gastrointestinal function, meal appearance, and glucose metabolism in type 2 diabetes. Diabetes 2007 May; 56(5):1475-80.
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  28. Dingli D, Wolf RC, Vella A. Imatinib and type 2 diabetes. Endocr Pract 2007 Mar-Apr; 13(2):126-30.
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  29. Ortu M, Vaccarezza M, Trovati S, Galli M, Gervasoni C, Vella A. A martial arts injury: karate induced unilateral haematoma of the adrenal gland. Br J Sports Med 2006 Aug; 40(8):730-1; discussion 731. Epub 2006 May 24.
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  30. Smyth DJ, Howson JM, Payne F, Maier LM, Bailey R, Holland K, Lowe CE, Cooper JD, Hulme JS, Vella A, Dahlman I, Lam AC, Nutland S, Walker NM, Twells RC, Todd JA. Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases. BMC Med Genet 2006; 7:20. Epub 2006 Mar 06.
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  31. Morris GA, Lowe CE, Cooper JD, Payne F, Vella A, Godfrey L, Hulme JS, Walker NM, Healy BC, Lam AC, Lyons PA, Todd JA. Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes. BMC Genet 2006; 7:12. Epub 2006 Feb 22.
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  32. Vella A, Cooper JD, Lowe CE, Walker N, Nutland S, Widmer B, Jones R, Ring SM, McArdle W, Pembrey ME, Strachan DP, Dunger DB, Twells RC, Clayton DG, Todd JA. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet 2005 May; 76(5):773-9.
  33. Stewart CE, Vella A. Acarbose in liver cirrhosis: cognitive or glycemic control? Clin Gastroenterol Hepatol 2005 Feb; 3(2):108-9.
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  34. Maier LM, Smyth DJ, Vella A, Payne F, Cooper JD, Pask R, Lowe C, Hulme J, Smink LJ, Fraser H, Moule C, Hunter KM, Chamberlain G, Walker N, Nutland S, Undlien DE, Ronningen KS, Guja C, Ionescu-Tirgoviste C, Savage DA, Strachan DP, Peterson LB, Todd JA, Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes. BMC Genet 2005; 6(1):9. Epub 2005 Feb 18.
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  35. Smyth D, Cooper JD, Collins JE, Heward JM, Franklyn JA, Howson JM, Vella A, Nutland S, Rance HE, Maier L, Barratt BJ, Guja C, Ionescu-Tirgoviste C, Savage DA, Dunger DB, Widmer B, Strachan DP, Ring SM, Walker N, Clayton DG, Twells RC, Gough SC, Todd JA. Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes 2004 Nov; 53(11):3020-3.
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  36. Vella A, Rizza RA. Extrapancreatic effects of GIP and GLP-1. Horm Metab Res 2004 Nov-Dec; 36(11-12):830-6.
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  37. Vella A, Camilleri M, Rizza RA. The gastrointestinal tract and glucose tolerance. Curr Opin Clin Nutr Metab Care 2004 Jul; 7(4):479-84.
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  38. Vella A, Howson JM, Barratt BJ, Twells RC, Rance HE, Nutland S, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE, Ronningen KS, Guja C, Ionescu-Tirgoviste C, Savage DA, Todd JA. Lack of association of the Ala(45)Thr polymorphism and other common variants of the NeuroD gene with type 1 diabetes. Diabetes 2004 Apr; 54(4):1158-61.
  39. Reed AS, Charkoudian N, Vella A, Shah P, Rizza RA, Joyner MJ. Forearm vascular control during acute hyperglycemia in healthy humans. Am J Physiol Endocrinol Metab 2004 Mar; 286(3):E472-80.
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  40. Eftychi C, Howson JM, Barratt BJ, Vella A, Payne F, Smyth DJ, Twells RC, Walker NM, Rance HE, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE, Ronningen KS, Guja C, Ionescu-Tiirgoviste C, Savage DA, Todd JA. Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes. Diabetes 2004 Mar; 53(3):870-3.
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  41. Adkins A, Basu R, Persson M, Dicke B, Shah P, Vella A, Schwenk WF, Rizza R. Higher insulin concentrations are required to suppress gluconeogenesis than glycogenolysis in nondiabetic humans. Diabetes 2003 Sep; 52(9):2213-20.
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  42. Delgado-Aros S, Vella A, Camilleri M, Low PA, Burton DD, Thomforde GM, Stephens D. Effects of glucagon-like peptide-1 and feeding on gastric volumes in diabetes mellitus with cardio-vagal dysfunction. Neurogastroenterol Motil 2003 Aug; 15(4):435-43.
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  43. Vella A, Reed AS, Charkoudian N, Shah P, Basu R, Basu A, Joyner MJ, Rizza RA. Glucose-induced suppression of endogenous glucose production: dynamic response to differing glucose profiles. Am J Physiol Endocrinol Metab 2003 Jul; 285(1):E25-30.
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  44. Vella A, Service FJ, O'Brien PC. Glucose counterregulatory hormones in the 72-hour fast. Endocr Pract 2003 Mar-Apr; 9(2):115-8.
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  45. Shah P, Vella A, Basu A, Basu R, Adkins A, Schwenk WF, Johnson CM, Nair KS, Jensen MD, Rizza RA. Elevated free fatty acids impair glucose metabolism in women - Decreased stimulation of muscle glucose uptake and suppression of splanchnic glucose production during combined hyperinsulinemia and hyperglycemia. Diabetes 2003 Jan; 52(1):38-42.
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  46. Basu R, Di Camillo B, Toffolo G, Basu A, Shah P, Vella A, Rizza R, Cobelli C. Use of a novel triple-tracer approach to assess postprandial glucose metabolism. Am J Physiol Endocrinol Metab 2003 Jan; 284(1):E55-69.
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  47. Kurtkaya-Yapicier O, Scheithauer BW, Carney JA, Kovacs K, Horvath E, Stratakis CA, Vidal S, Vella A, Young WF Jr, Atkinson JL, Lloyd RV, Kontogeorgos G. Pituitary adenoma in Carney complex: an immunohistochemical, ultrastructural, and immunoelectron microscopic study. Ultrastruct Pathol 2002 Nov-Dec; 26(6):345-53.
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  48. Vella A, Shah P, Reed AS, Adkins AS, Basu R, Rizza RA. Lack of effect of exendin-4 and glucagon-like peptide-1-(7,36)-amide on insulin action in non-diabetic humans. Diabetologia 2002 Oct; 45(10):1410-5.
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  49. Charkoudian N, Vella A, Reed AS, Minson CT, Shah P, Rizza RA, Joyner MJ. Cutaneous vascular function during acute hyperglycemia in healthy young adults. J Appl Physiol 2002 Oct; 93(4):1243-50.
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  50. Vella A, Shah P, Basu R, Basu A, Camilleri M, Schwenk WF, Rizza RA. Effect of enteral vs. parenteral glucose delivery on initial splanchnic glucose uptake in nondiabetic humans. Am J Physiol Endocrinol Metab 2002 Aug; 283(2):E259-66.
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  51. Vella A, Lee JS, Camilleri M, Szarka LA, Burton DD, Zinsmeister AR, Rizza RA, Klein PD. Effects of pramlintide, an amylin analogue, on gastric emptying in type 1 and 2 diabetes mellitus. Neurogastroenterol Motil 2002 Apr; 14(2):123-31.
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  52. Delgado-Aros S, Kim DY, Burton DD, Thomforde GM, Stephens D, Brinkmann BH, Vella A, Camilleri M. Effect of GLP-1 on gastric volume, emptying, maximum volume ingested, and postprandial symptoms in humans. Am J Physiol Gastrointest Liver Physiol 2002 Mar; 282(3):G424-31.
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  53. Shah P, Vella A, Basu A, Basu R, Adkins A, Schwenk WF, Johnson CM, Nair KS, Jensen MD, Rizza RA. Effects of free fatty acids and glycerol on splanchnic glucose metabolism and insulin extraction in nondiabetic humans. Diabetes 2002 Feb; 51(2):301-10.
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  54. Vella A, Pineda AA, O'Brien T. Low-density lipoprotein apheresis for the treatment of refractory hyperlipidemia. Mayo Clin Proc 2001 Oct; 76(10):1039-46.
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  55. Vella A, Young WF. Pituitary apoplexy. Endocrinologist 2001 Jul-Aug; 11(4):282-8.
  56. Basu A, Basu R, Shah P, Vella A, Johnson CM, Jensen M, Nair KS, Schwenk WF, Rizza RA. Type 2 diabetes impairs splanchnic uptake of glucose but does not alter intestinal glucose absorption during enteral glucose feeding: additional evidence for a defect in hepatic glucokinase activity. Diabetes 2001 Jun; 50(6):1351-62.
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  57. Basu A, Basu R, Shah P, Vella A, Rizza RA, Jensen MD. Systemic and regional free fatty acid metabolism in type 2 diabetes. Am J Physiol Endocrinol Metab 2001 Jun; 280(6):E1000-6.
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  58. Vella A, Shah P, Basu R, Basu A, Camilleri M, Schwenk WF, Rizza RA. Type I diabetes mellitus does not alter initial splanchnic glucose extraction or hepatic UDP-glucose flux during enteral glucose administration. Diabetologia 2001 Jun; 44(6):729-37.
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  59. Vella A, Thompson GB, Grant CS, van Heerden JA, Farley DR, Young WF Jr. Laparoscopic adrenalectomy for adrenocorticotropin-dependent Cushing's syndrome. J Clin Endocrinol Metab 2001 Apr; 86(4):1596-9.
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  60. Vella A, Shah P, Basu R, Basu A, Camilleri M, Schwenk FW, Holst JJ, Rizza RA. Effect of glucagon-like peptide-1(7-36)-amide on initial splanchnic glucose uptake and insulin action in humans with type 1 diabetes. Diabetes 2001 Mar; 50(3):565-72.
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  61. Vella A, Nippoldt TB, Morris JC 3rd. Adrenal hemorrhage: a 25-year experience at the Mayo Clinic. Mayo Clin Proc 2001 Feb; 76(2):161-8.
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  62. Shah P, Vella A, Basu A, Basu R, Schwenk WF, Rizza RA. Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab 2000 Nov; 85(11):4053-9.
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  63. Samsom M, Szarka LA, Camilleri M, Vella A, Zinsmeister AR, Rizza RA. Pramlintide, an amylin analog, selectively delays gastric emptying: potential role of vagal inhibition. Am J Physiol Gastrointest Liver Physiol 2000 Jun; 278(6):G946-51.
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  64. Vella A, Shah P, Basu R, Basu A, Holst JJ, Rizza RA. Effect of glucagon-like peptide 1(7-36) amide on glucose effectiveness and insulin action in people with type 2 diabetes. Diabetes 2000 Apr; 49(4):611-7.
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  65. Basu A, Basu R, Shah P, Vella A, Johnson CM, Nair KS, Jensen MD, Schwenk WF, Rizza RA. Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism - evidence for a defect in haptic glucokinase activity. Diabetes 2000 Feb; 49(2):272-83.
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  66. Vella A, Carlson LA, Blier B, Felty C, Kuiper JD, Rooke TW. Circulator boot therapy alters the natural history of ischemic limb ulceration. Vasc Med 2000; 5(1):21-5.
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  67. Vella A, Gerber TC, Hayes DL, Reeder GS. Digoxin, hypercalcaemia, and cardiac conduction. Postgrad Med J 1999 Sep; 75(887):554-6.
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  68. Vella A, McPhail I, Litin S. Unilateral proptosis in a 74-year-old woman. Adv Exp Med Biol 1999; 455:529-33.
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  69. Vella A, Farrugia G. D-lactic acidosis: pathologic consequence of saprophytism. Mayo Clin Proc 1998 May; 73(5):451-6.
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  70. Vella A, Dinneen SF, DeGroen P. Toglitazone hepatotoxicity. Annals Int Med 1998; 129:1080.
  71. Vella A, McPhail IR, Litin SC. 74-year-old woman with cough and proptosis. Mayo Clin Proc 1997 Jun; 72(6):575-8.
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  72. Vella A, Farrugia G. 90-year-old man with fever and melena (translated into Polish). Medycyna Prakyczna 1997 May.
  73. Vella A, Farrugia G. 90-year-old man with fever and melena. Mayo Clin Proc 1996 Dec; 71(12):1205-8.
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