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Publications - Sean C . Dowdy, M.D.

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  1. Li JP, Dowdy S, Tipton T, Podratz K, Lu WG, Xie X, Jiang SW. HE4 as a biomarker for ovarian and endometrial cancer management. Expert Rev Mol Diagn 2009 Sep; 9(6):555-66.
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  2. Li J, Dowdy S, Tipton T, Podratz K, Lu WG, Xie X, Jiang SW. HE4 as a biomarker for ovarian and endometrial cancer management. Expert Rev Mol Diagn 2009 Sep; 9(6):555-66.
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  3. Marnitz S, Dowdy S, Lanowska M, Schneider A, Podratz K, Köhler C. Exenterations 60 years after first description: results of a survey among US and German Gynecologic Oncology Centers. Int J Gynecol Cancer 2009 Jul; 19(5):974-7.
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  4. Marnitz S, Dowdy S, Lanowska M, Schneider A, Podratz K, Köhler C. Exenterations 60 Years After First Description: Results of a Survey Among US and German Gynecologic Oncology Centers. Int J Gynecol Cancer 2009 Jul; 19(5):974-977.
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  5. Marnitz S, Dowdy S, Lanowska M, Schneider A, Podratz K, Kohler C. Exenterations 60 years after first description: results of a survey among US and German Gynecologic Oncology Centers. Int J Gynecol Cancer 2009 Jul; 19(5):974-7.
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  6. Liu P, Khurana, A, Rattan R, He X, Gilks B, Kalloger S, Dowdy SC, Shridhar V. Regulation of HSulf-1 expression by variant hepatic nuclear factor 1 (vHNF1) in ovarian cancer. Cancer Res 1 2009 Jun 1; 69(11):4843-50.
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  7. Liu P, Khurana A, Rattan R, He X, Kalloger S, Dowdy S, Gilks B, Shridhar V. Regulation of HSulf-1 expression by variant hepatic nuclear factor 1 in ovarian cancer. Cancer Res 2009 Jun 1; 69(11):4843-50.
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  8. Mariani A, Dowdy SC, Podratz KC. New surgical staging of endometrial cancer: 20 years later. Int J Gynaecol Obstet 2009 May; 105(2):110-1. Epub 2009 Mar 14.
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  9. Mariani A, Dowdy SC, Podratz KC. New surgical staging of endometrial cancer: 20 years later. Int J Gynaecol Obstet 2009 May; 105(2):110-1.
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  10. Aletti GD, Dowdy SC, Gostout BS, Jones MB, Stanhope RC, Wilson TO, Podratz KC, Cliby WA. Quality improvement in the surgical approach to advanced ovarian cancer: the Mayo Clinic experience. J Am Coll Surg 2009 Apr; 208(4):614-20.
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  11. Thomas MB, Keeney GL, Podratz KC, Dowdy SC. Endometrial Stromal Sarcoma: Treatment, Patterns of Recurrence. Int J Gynecol Cancer 2009 Feb; 19(2):253-6.
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  12. Thomas MB, Keeney GL, Podratz KC, Dowdy SC. Endometrial stromal sarcoma: treatment and patterns of recurrence. Int J Gynecol Cancer 2009 Feb; 19(2):253-6.
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  13. Konecny GE, Santos L, Winterhoff B, Hatmal M, Keeney GL, Mariani A, Jones M, Neuper C, Thomas B, Muderspach L, Riehle D, Wang HJ, Dowdy S, Podratz KC, Press MF. HER2 gene amplification and EGFR expression in a large cohort of surgically staged patients with nonendometrioid (type II) endometrial cancer. Br J Cancer Epub 2008 Dec 16 2009 Jan 13; 100(1):89-95.
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  14. Konecny GE, Santos L, Winterhoff B, Hatmal M, Keeney GL, Mariani A, Jones M, Neuper C, Thomas B, Muderspach L, Riehle D, Wang HJ, Dowdy S, Podratz KC, Press MF. HER2 gene amplification and EGFR expression in a large cohort of surgically staged patients with nonendometrioid (type II) endometrial cancer. Br J Cancer 2009 Jan 13; 100(1):89-95. Epub 2008 Dec 16.
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  15. Thomas MB, Keeney GL, Podratz KC, Dowdy SC. Endometrial stromal sarcoma: treatment, patterns of recurrence. International Journal of Gynecological Cancer (In Press) 2009.
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  16. Aletti GD, Dowdy SC, Gostout BS, Jones MB, Stanhope RC, Wilson TO, Podratz KC, Cliby WA. Quality improvement in the surgical approach to advanced ovarian cancer: The Mayo Clinic experience. J Am Coll Surg 208 2009:614-620.
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  17. Liu P, Khurana, A, Rattan R, He X, Gilks B, Kalloger S, Dowdy SC, Shridhar V. Regulation of HSulf-1 expression by variant hepatic nuclear factor 1 (vHNF1) in ovarian cancer. Cancer Research In Press 2009.
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  18. Dowdy SC, Aletti G, Cliby WA, Podratz KC, Mariani A. Extra-peritoneal laparoscopic para-aortic lymphadenectomy--a prospective cohort study of 293 patients with endometrial cancer. Gynecol Oncol 2008 Dec; 111(3):418-24. Epub 2008 Oct 02.
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  19. Dozois EJ, Larson DW, Dowdy SC, Pool VP, Holubar SD, Cima RR. Transvaginal colonic extraction following combined hysterectomy and laparoscopic total colectomy: a natural orifice approach. Tech Coloproctol 2008 Sep; 12(3):251-4 Epub 2008 Aug 5.
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  20. Dozois EJ, Larson DW, Dowdy SC, Poola VP, Holubar SD, Cima RR. Transvaginal colonic extraction following combined hysterectomy and laparoscopic total colectomy: a natural orifice approach. Tech Coloproctol 2008 Sep; 12(3):251-4. Epub 2008 Aug 05.
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  21. Jiang SW, Li J, Podratz K, Dowdy S. Application of DNA methylation biomarkers for endometrial cancer management Expert Rev Mol Diagn Review 2008 Sep; 8(5):607-16.
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  22. Jiang SW, Li JP, Podratz K, Dowdy S. Application of DNA methylation biomarkers for endometrial cancer management. Expert Rev Mol Diagn 2008 Sep; 8(5):607-16.
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  23. Dozois EJ, Larson DW, Dowdy SC, Poola VP, Holubar SD, Cima RR. Transvaginal colonic extraction following combined hysterectomy and laparoscopic total colectomy: a natural orifice approach Tech. Coloprotol 8/2008.
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  24. Thomas MB, Wright JD, Leiser AL, Chi DS, Mutch DG, Podratz KC, Dowdy SC. Clear cell carcinoma of the cervix: a multi-institutional review in the post-DES era. Gynecol Oncol 2008 Jun; 109(3):335-9. Epub 2008 Apr 03.
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  25. Dowdy SC, Loewen RT, Aletti G, Feitoza SS, Cliby W. Assessment of outcomes and morbidity following diaphragmatic peritonectomy for women with ovarian carcinoma. Gynecol Oncol 2008 May; 109(2):303-7. Epub 2008 Apr 01.
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  26. Konecny GE, Agarwal R, Keeney GA, Winterhoff B, Jones MB, Mariani A, Riehle D, Neuper C, Dowdy SC, Wang HJ, Morin PJ, Podratz KC. Claudin-3 and claudin-4 expression in serous papillary, clear-cell, and endometrioid endometrial cancer. Gynecol Oncol 2008 May; 109(2):263-9. Epub 2008 Mar 07.
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  27. Mariani A, Dowdy SC, Cliby WA, Gostout BS, Jones MB, Wilson TO, Podratz KC. Prospective assessment of lymphatic dissemination in endometrial cancer: a paradigm shift in surgical staging. Gynecol Oncol 2008 Apr; 109(1):11-8. Epub 2008 Mar 04.
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  28. Konecny GE, Agarwal R, Keeney GA, Winterhoff B, Jones MB, Mariani A, Riehle D, Neuper C, Dowdy SC, Wang HJ, Morin PJ, Podratz KC. Claudin-3 and claudin-4 expression in serous papillary, clear-cell, and endometrioid endometrial cancer. Gynecol Oncol 2008 Feb 29 Epub [Epub ahead of print].
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  29. Konecny GE, Agarwal R, Keeney GA, Winterhoff B, Jones MB, Mariani A, Riehle D, Neuper C, Dowdy SC, Wang HJ, Morin PJ, Podratz KC. Claudin-3 and claudin-4 expression in serous papillary, clear-cell, and endometrioid endometrial cancer. Gynecol Oncol 2008 Feb 29. [Epub ahead of print]
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  30. Thomas M, Mariani A, Wright JD, Madarek EO, Powell MA, Mutch DG, Podratz KC, Dowdy SC. Surgical management and adjuvant therapy for patients with uterine clear cell carcinoma: a multi-institutional review. Gynecol Oncol 2008 Feb; 108(2):293-7.
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  31. Thomas M, Mariani A, Wright JD, Madarek EO, Powell MA, Mutch DG, Podratz KC, Dowdy SC. Surgical management and adjuvant therapy for patients with uterine clear cell carcinoma: a multi-institutional review. Gynecol Oncol 2008 Feb; 108(2):293-7. Epub 2007 Dec 21.
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  32. Bakkum-Gamez JN, Gonzalez-Bosquet J, Laack NN, Mariani A, Dowdy SC. Current issues in the management of endometrial cancer. Mayo Clin Proc 2008 Jan; 83(1):97-112.
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  33. Mariani A, Dowdy S, Podratz K. Surgical Treatment of Endometrial Cancer: the Role of Pelvic and Para-aortic Lymph Node Dissection (A View from the USA). The Obstetrician & Gynaecologist 2008. Epub In press.
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  34. Thomas M, Wright J, Leiser A, Chi D, Mutch D, Podratz K, Dowdy S. Clear cell carcinoma of the cervix: A multi-institutional review in the post-DES era. Gynecol Oncol 2008 Epub In press.
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  35. Mariani A, Dowdy S, Cliby W, Gostout B, Jones M, Wilson T, Podratz K. Prospective assessment of lymphatic dissemination in endometrial cancer: A paradigm shift in surgical staging. Gynecol Oncol 2008 Epub In press.
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  36. Bakkum-Gamez JN, Gonzalez-Bosquet J, Laack NN, Mariani A, Dowdy SC. Current issues in the management of endometrial cancer. Mayo Clin Proc 2008; 83(1):97-112.
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  37. Dowdy SC, Loewen R, Aletti G, Feitoza S, Cliby WA. Assessment of outcomes and morbidity following diaphragmatic peritonectomy for women with ovarian carcinoma. Gynecol Oncol 2008 Epub In press.
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  38. Aletti GD, Dowdy SC, Podratz KC, Cliby WA. Relationship among surgical complexity, short-term morbidity, and overall survival in primary surgery for advanced ovarian cancer. Am J Obstet Gynecol 2007 Dec; 197(6):676.e1-7.
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  39. Thomas MB, Mariani A, Cliby WA, Keeney GL, Podratz KC, Dowdy SC. Role of cytoreduction in stage III and IV uterine papillary serous carcinoma. Gynecol Oncol 2007 Nov; 107(2):190-3. Epub 2007 Sep 6.
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  40. Thomas MB, Mariani A, Cliby WA, Keeney GA, Podratz KC, Dowdy SC. Role of systematic lymphadenectomy and adjuvant therapy in stage I uterine papillary serous carcinoma. Gynecol Oncol 2007 Nov; 107(2):186-9. Epub 2007 Aug 3.
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  41. Dowdy SC, Mariani A, Bakkum JN, Cliby WA, Keeney GL, Podratz KC. Treatment of pulmonary recurrences in patients with endometrial cancer. Gynecol Oncol 2007 Nov; 107(2):242-7. Epub 2007 Sep 17.
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  42. Zhou XC, Dowdy SC, Podratz KC, Jiang SW. Epigenetic considerations for endometrial cancer prevention, diagnosis and treatment. Gynecol Oncol 2007 Oct; 107(1):143-53.
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  43. Thomas MB, Mariani A, Cliby WA, Keeney GL, Podratz KC, Dowdy SC. Role of cytoreduction in stage III and IV uterine papillary serous carcinoma. Gynecol Oncol 2007 Sep 5. [Epub ahead of print]
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  44. Thomas MB, Mariani A, Cliby WA, Keeney GA, Podratz KC, Dowdy SC. Role of systematic lymphadenectomy and adjuvant therapy in stage I uterine papillary serous carcinoma. Gynecol Oncol 2007 Aug 2. [Epub ahead of print]
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  45. Jiang S, Dowdy SC, Meng XW, Wang ZY, Jones MB, Podratz KC, Jiang SW. Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells. Gynecol Oncol 2007 May; 105(2):493-500.
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  46. Aletti GD, Dowdy SC, Podratz KC, Cliby WA. Analysis of factors impacting operability in stage IV ovarian cancer: rationale use of a triage system. Gynecol Oncol 2007 Apr; 105(1):84-9.
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  47. Axtell AE, Lee MH, Bristow RE, Dowdy SC, Cliby WA, Raman S, Weaver JP, Gabbay M, Ngo M, Lentz S, Cass I, Li AJ, Karlan BY, Holschneider CH. Multi-institutional reciprocal validation study of computed tomography predictors of suboptimal primary cytoreduction in patients with advanced ovarian cancer. J Clin Oncol 2007 Feb 1; 25(4):384-9.
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  48. Aletti G, Dowdy S, Podratz K, Cliby W. Relationship among surgical complexity, short-term morbidity, and overall survival in primarly surgery for advanced ovarian cancer American Journal of Obstetrics and Gynecology 12/2007:676e1-676e7.
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  49. Thomas MB, Mariani A, Cliby WA, Keeney GL, Podratz KC, Dowdy SC. Role of systematic lymphadenectomy and adjuvant therapy in stage I uterine papillary serous carcinoma. Gynecol Oncol 2007; In press.
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  50. Thomas MB, Mariani A, Cliby WA, Keeney GL, Podratz KC, Dowdy SC. Role of cytoreduction in stage III and IV uterine papillary serous carcinoma. Gynecol Oncol 2007; In press.
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  51. Dowdy SC, Mariani A, Bakkum J, Cliby, WA, Keeney GL, Podratz KC. Outcomes of pulmonary failures in women with endometrial cancer. Gynecol Oncol 2007; In press.
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  52. Aletti GD, Dowdy S, Podratz KC, Cliby WA. Role of lymphadenectomy in the management of grossly apparent advanced stage epithelial ovarian cancer. Am J Obstet Gynecol 2006 Dec; 195(6):1862-8.
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  53. Dowdy SC, Jiang S, Zhou XC, Hou X, Jin F, Podratz KC, Jiang SW. Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells. Mol Cancer Ther 2006 Nov; 5(11):2767-76.
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  54. Xiong Y, Dowdy SC, Eberhardt NL, Podratz KC, Jiang SW. hMLH1 promoter methylation and silencing in primary endometrial cancers are associated with specific alterations in MBDs occupancy and histone modifications. Gynecol Oncol 2006 Oct; 103(1):321-8. Epub 2006 May 15.
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  55. Mariani A, Dowdy SC, Cliby WA, Haddock MG, Keeney GL, Lesnick TG, Podratz KC. Efficacy of systematic lymphadenectomy and adjuvant radiotherapy in node-positive endometrial cancer patients. Gynecol Oncol 2006 May; 101(2):200-8. Epub 2006 Feb 28.
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  56. Dowdy SC, Mariani A, Cliby WA, Haddock MG, Petersen IA, Sim FH, Podratz KC. Radical pelvic resection and intraoperative radiation therapy for recurrent endometrial cancer: technique and analysis of outcomes. Gynecol Oncol 2006 May; 101(2):280-6.
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  57. Aletti GD, Dowdy SC, Podratz KC, Cliby WA. Surgical treatment of diaphragm disease correlates with improved survival in optimally debulked advanced stage ovarian cancer. Gynecol Oncol 2006 Feb; 100(2):283-7. Epub 2005 Sep 22.
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  58. Aletti GD, Dowdy SC, Gostout BS, Jones MB, Stanhope CR, Wilson TO, Podratz KC, Cliby WA. Aggressive surgical effort and improved survival in advanced-stage ovarian cancer. Obstet Gynecol 2006 Jan; 107(1):77-85.
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  59. Mariani A, Dowdy SC, Podratz KC. Outcomes of pulmonary failures in women with endometrial cancer. Gynecol Oncol Manuscript in progress 2006.
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  60. Dowdy SC, Gostout BS, Shridhar V, Wu X, Smith DI, Podratz KC, Jiang SW. Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines. Gynecol Oncol 2005 Oct; 99(1):126-34.
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  61. Xiong YN, Dowdy SC, Bosquet JG, Zhao Y, Eberhardt NL, Podratz KC, Jiang SW. Epigenetic-mediated upregulation of progesterone receptor B gene in endometrial cancer cell lines. Gynecol Oncol 2005 Oct; 99(1):135-41.
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  62. Dowdy SC. Pravention und diagnostik von lymphknotenrezidiven beim endometriumkarzinom. Der Onkologe 2005 Aug; 11(8):866-9.
  63. Mariani A, Sebo TJ, Katzmann JA, Riehle DL, Dowdy SC, Keeney GL, Lesnick TG, Podratz KC. HER-2/neu overexpression and hormone dependency in endometrial cancer: analysis of cohort and review of literature. Anticancer Res 2005 Jul-Aug; 25(4):2921-7.
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  64. Mariani A, Dowdy SC, Keeney GL, Haddock MG, Lesnick TG, Podratz KC. Predictors of vaginal relapse in stage I endometrial cancer. Gynecol Oncol 2005 Jun; 97(3):820-7.
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  65. Xiong YN, Dowdy SC, Podratz KC, Jin F, Attewell JR, Eberhardt NL, Jiang SW. Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells. Cancer Res 2005 Apr 1; 65(7):2684-9.
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  66. Xiong YN, Dowdy SC, Xue AL, Jiang SJ, Eberhardt NL, Podratz KC, Jiang SW. Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers. Gynecol Oncol 2005 Mar; 96(3):601-9.
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  67. Jin F, Dowdy SC, Xiong YN, Eberhardt NL, Podratz KC, Jiang SN. Up-regulation of DNA methyltransferase 3B expression in endometrial cancers. Gynecol Oncol 2005 Feb; 96(2):531-8.
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  68. Dowdy SC, Metzinger DS, Gebhart JB, Srivatsa P, Haddock MG, Suman VJ, Podratz KC. Salvage whole-abdominal radiation therapy after second-look laparotomy or secondary debulking surgery in patients with ovarian cancer. Gynecol Oncol 2005 Feb; 96(2):389-94.
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  69. Dowdy SC, Mariani A, Reinholz MM, Keeney GL, Spelsberg TC, Podratz KC, Janknecht R. Overexpression of the TGF-beta antagonist Smad7 in endometrial cancer. Gynecol Oncol 2005 Feb; 96(2):368-73.
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  70. Mariani A, Dowdy SC, Keeney GL, Long HJ, Lesnick TG, Podratz KC. High-risk endometrial cancer subgroups: candidates for target-based adjuvant therapy. Gynecol Oncol 2004 Oct; 95(1):120-6.
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  71. Dowdy SC, Stefanek M, Hartmann LC. Surgical risk reduction: prophylactic salpingo-oophorectomy and prophylactic mastectomy. Am J Obstet Gynecol 2004 Oct; 191(4):1113-23.
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  72. Cliby W, Dowdy S, Feitoza SS, Gostout BS, Podratz KC. Diaphragm resection for ovarian cancer: technique and short-term complications. Gynecol Oncol 2004 Sep; 94(3):655-60.
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  73. Dowdy SC, Mullany SA, Brandt KR, Huppert BJ, Cliby WA. The utility of computed tomography scans in predicting suboptimal cytoreductive surgery in women with advanced ovarian carcinoma. Cancer 2004 Jul 15; 101(2):346-52.
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  74. Dowdy SC, Constantinou CL, Hartmann LC, Keeney GL, Suman VJ, Hillman DW, Podratz KC. Long-term follow-up of women with ovarian cancer after positive second-look laparotomy. Gynecol Oncol 2003 Dec; 91(3):563-8.
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  75. Dowdy SC, Mariani A, Janknecht R. HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81. J Biol Chem 2003 Nov 7; 278(45):44377-84.
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  76. Dowdy SC, Cliby WA. Preparing for the unexpected: encountering gynecologic problems when operating for colon cancer. Current Surgery 2003 Jan; 60(1):12-16.
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  77. Dowdy SC, Boardman CH, Wilson TO, Podratz KC, Hartmann LC, Long HJ. Multimodal therapy including neoadjuvant methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) for stage IIB to IV cervical cancer. American Journal of Obstetrics & Gynecology 2002 Jun; 186(6):1167-73.
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  78. Dowdy SC, O'Kane DJ, Keeney GL, Boyd J, Podratz KC. Telomerase activity in sex cord-stromal tumors of the ovary. Gynecol Oncol 2001 Aug; 82(2):257-60.
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  79. Dowdy SC, Pfeifer EA, Longcope DC, Cliby WA. Unusual recurrence of ovarian carcinoma 9 years after initial diagnosis. Gynecol Oncol 1999 Sep; 74(3):495-8.
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  80. Aletti GD, Dowdy SC, Podratz KC, Cliby WA. Analysis of factors impacting operability in stage IV ovarian cancer: Rationale use of a triage system. Gynecol Oncol 2007 Apr; 105(1):84-9.
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  81. Jiang S, Dowdy SC, Meng XW, Podratz KC, Jiang SW. Histone deacetylase inhibitors induce apoptosis in both type I and type II endometrial cancer cells. Gynecology Oncology 2007; 105(2):493-500.
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