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Publications - Roshini S . Abraham, Ph.D.

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  1. Cummins NW, Deziel PJ, Abraham RS, Razonable RR. Deficiency of cytomegalovirus (CMV)-specific CD8+ T cells in patients presenting with late-onset CMV disease several years after transplantation. Transpl Infect Dis 2009 Feb; 11(1):20-7. Epub 2008 Sep 21.
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  2. Joshi AY, Iyer VN, Boyce TG, Hagan JB, Park MA, Abraham RS. Elevated serum immunoglobulin E (IgE): when to suspect hyper-IgE syndrome-A 10-year pediatric tertiary care center experience. Allergy Asthma Proc 2009 Jan-Feb; 30(1):23-7.
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  3. Kumar N, Hagan JB, Abraham RS, Aksamit AJ. Common variable immunodeficiency - associated myelitis : Report of treatment with infliximab. J Neurol 2008 Nov; 255(11):1821-4 Epub 2008 Jul 21.
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  4. Park MA, Li JT, Hagan JB, Maddox DE, Abraham RS. Common variable immunodeficiency: a new look at an old disease. Lancet 2008 Aug 9; 372(9637):489-502.
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  5. Shepard BD, De Forni D, McNamara DR, Foli A, Rizza SA, Abraham RS, Knutson K, Wettstein PJ, Lori F, Badley AD. Beneficial effect of TRAIL on HIV burden, without detectable immune consequences. PLoS One 2008; 3(8):e3096. Epub 2008 Aug 28.
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  6. Martin W, Abraham R, Shanafelt T, Clark RJ, Bone N, Geyer SM, Katzmann JA, Bradwell A, Kay NE, Witzig TE. Serum-free light chain-a new biomarker for patients with B-cell non-Hodgkin lymphoma and chronic lymphocytic leukemia. Transl Res 2007 Apr; 149(4):231-5.
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  7. Abraham RS, Manske MK, Zuckerman NS, Sohni A, Edelman H, Shahaf G, Timm MM, Dispenzieri A, Gertz MA, Mehr R. Novel analysis of clonal diversification in blood B cell and bone marrow plasma cell clones in immunoglobulin light chain amyloidosis. J Clin Immunol 2007 Jan; 27(1):69-87. Epub 2006 Dec 28.
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  8. Katzmann JA, Dispenzieri A, Kyle RA, Snyder MR, Plevak MF, Larson DR, Abraham RS, Lust JA, Melton LJ 3rd, Rajkumar SV. Elimination of the need for urine studies in the screening algorithm for monoclonal gammopathies by using serum immunofixation and free light chain assays. Mayo Clin Proc 2006 Dec; 81(12):1575-8.
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  9. Steiman-Shimony A, Edelman H, Hutzler A, Barak M, Zuckerman NS, Shahaf G, Dunn-Walters D, Stott DI, Abraham RS, Mehr R. Lineage tree analysis of immunoglobulin variable-region gene mutations in autoimmune diseases: chronic activation, normal selection. Cell Immunol 2006 Dec; 244(2):130-6. Epub 2007 Apr 16.
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  10. Manske MK, Zuckerman NS, Timm MM, Maiden S, Edelman H, Shahaf G, Barak M, Dispenzieri A, Gertz MA, Mehr R, Abraham RS. Quantitative analysis of clonal bone marrow CD19+ B cells: use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis. Clin Immunol 2006 Jul; 120(1):106-20. Epub 2006 Mar 03.
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  11. Dispenzieri A, Lacy MQ, Katzmann JA, Rajkumar SV, Abraham RS, Hayman SR, Kumar SK, Clark R, Kyle RA, Litzow MR, Inwards DJ, Ansell SM, Micallef IM, Porrata LF, Elliott MA, Johnston PB, Greipp PR, Witzig TE, Zeldenrust SR, Russell SJ, Gastineau D, Gertz Absolute values of immunoglobulin free light chains are prognostic in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation. Blood 2006 Apr 15; 107(8):3378-83. Epub 2006 Jan 05.
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  12. Steiman-Shimony A, Edelman H, Barak M, Shahaf G, Dunn-Walters D, Stott DI, Abraham RS, Mehr R. Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases. Journal of Autoimmunity Reviews 2006; 5:242-251.
  13. Katzmann JA, Abraham RS, Dispenzieri A, Lust JA, Kyle RA. Diagnostic performance of quantitative kappa and lambda free light chain assays in clinical practice. Clin Chem 2005 May; 51(5):878-81.
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  14. Abraham RS, Ballman KV, Dispenzieri A, Grill DE, Manske MK, Price-Troska TL, Paz NG, Gertz MA, Fonseca R. Functional gene expression analysis of clonal plasma cells identifies a unique molecular profile for light chain amyloidosis. Blood 2005 Jan 15; 105(2):794-803.
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  15. Abraham RS, Geyer SM, Ramirez-Alvarado M, Price-Troska TL, Gertz MA, Fonseca R. Analysis of somatic hypermutation and antigenic selection in the clonal B cell in immunoglobulin light chain amyloidosis (AL). J Clin Immunol 2004 Jul; 24(4):340-53.
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  16. Bergen HR, Abraham RS, Johnson KL, Bradwell AR, Naylor S. Characterization of amyloidogenic immunoglobulin light chains directly from serum by on-line immunoaffinity isolation. Biomed Chromatogr 2004 Apr; 18(3):191-201.
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  17. Abraham RS, Geyer SM, Price-Troska TL, Allmer C, Kyle RA, Gertz MA, Fonseca R. Immunoglobulin light chain variable (V) region genes influence clinical presentation and outcome in light chain-associated amyloidosis (AL). Blood 2003 May 15; 101(10):3801-8.
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  18. Abraham RS, Katzmann JA, Clark RJ, Bradwell AR, Kyle RA, Gertz MA. Quantitative analysis of serum free light chains - A new marker for the diagnostic evaluation of primary systemic amyloidosis. Am J Clin Pathol 2003 Feb; 119(2):274-8.
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  19. Kudva YC, Rajagopalan G, Raju R, Abraham RS, Smart M, Hanson J, David CS. Modulation of insulitis and type 1 diabetes by transgenic HLA-DR3 and DQ8 in NOD mice lacking endogenous MHC class II. Hum Immunol 2002 Nov; 63(11):987-99.
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  20. Abraham RS, Charlesworth MC, Owen BAL, Benson LM, Katzmann JA, Reeder CB, Kyle RA. Trimolecular complexes of lambda light chain dimers in serum of a patient with multiple myeloma. Clin Chem 2002 Oct; 48(10):1805-11.
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  21. Katzmann JA, Clark RJ, Abraham RS, Bryant S, Lymp JF, Bradwell AR, Kyle RA. Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: Relative sensitivity for detection of monoclonal light chains. Clin Chem 2002 Sep; 48(9):1437-44.
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  22. Naumov YN, Bahjat KS, Gausling R, Abraham R, Exley MA, Koezuka Y, Balk SB, Strominger JL, Clare-Salzer M, Wilson SB. Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets. Proc Natl Acad Sci U S A 2001 Nov 20; 98(24):13838-43.
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  23. Kudva YC, Deng YJ, Rajagopalan G, Abraham RS, Marietta EV, Notkins AL, David CS. HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2. Hum Immunol 2001 Oct; 62(10):1099-1105.
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  24. Kudva YC, Deng YJ, Govindarajan R, Abraham RS, Marietta EV, Notkins AL, David CS. HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2. Hum Immunol 2001 Oct; 62(10):1099-105.
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  25. Kudva YC, Deng YJ, Rajagopalan, G, Abraham RS, Marietta EV, Notkins AL, David CS. HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2. Hum Immunol 2001 Oct; 62(10):1099-1105.
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  26. Abraham RS, Wen L, Marietta EV, David CS. Type 1 diabetes-predisposing MHC alleles influence the selection of glutamic acid decarboxylase (GAD) 65-specific T cells in a transgenic model. J Immunol 2001 Jan 15; 166(2):1370-9.
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  27. Abraham RS, Kudva YC, Wilson SB, Strominger JL, David CS. Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice. Diabetes 2000 Apr; 49(4):548-54.
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  28. Abraham RS, David CS. Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice. Curr Opin Immunol 2000 Feb; 12(1):122-9.
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  29. Das P, Abraham R, David C. HLA transgenic mice as models of human autoimmune diseases. Rev Immunogenet 2000; 2(1):105-14.
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  30. Abraham RS, Wilson SB, de Souza NF Jr, Strominger JL, Munn SR, David CS. NOD background genes influence T cell responses to GAD 65 in HLA-DQ8 transgenic mice. Hum Immunol 1999 Jul; 60(7):583-90.
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  31. Das P, Abraham RS, David CS. HLA transgenic mice as models of human autoimmune diseases. Reviews in Immunogenetics 1999 2; 2:105-11.
  32. Abraham RS, Kudva YC, Wilson SB, Strominger JL, David CS. NOD background genes influence T cell responses to GAD 65 in HLA-DQ8 transgenic mice. Diabetes 1999; 49:548-55.
  33. Singh N, Bhatia S, Abraham RS, Basu SK, George A, Bal V, Rath S. Modulation of T cell cytokine profiles and peptide-MHC complex availability in vivo by delivery to scavenger receptors via antigen maleylation. Journal of Immunology 1998; 160:4869-880.
  34. Abraham RS, Choudhury A, Basu SK, Bal V, Rath S. Disruption of T cell tolerance by directing a self-antigen to macrophage-specific scavenger receptor. Journal of Immunology 1997; 158:4029-35.
  35. Abraham RS, Singh N, Mukhopadhyay A, Basu S K, Bal V, Rath, S. Modulation of immunogenicity and antigenicity of proteins by maleylation to target scavenger receptors on macrophages. Journal of Immunology 1995; 154:1-8.
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