Publications - Roshini S. Abraham, Ph.D.

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  1. Kudva YC, Erickson JR, Parsaik A, Rostambeigi N, Thapa P, Abraham RS. Comprehensive immune monitoring reveals profound immunological changes in pancreas after kidney (PAK) transplant recipients. Hum Immunol. 2013 Jun; 74(6):738-45. Epub 2013 Mar 07.
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  2. Abraham RS, Recher M, Giliani S, Walter JE, Lee YN, Frugoni F, Maddox DE, Kirmani S, Notarangelo LD. Adult-onset manifestation of idiopathic T-cell lymphopenia due to a heterozygous RAG1 mutation. J Allergy Clin Immunol. 2013 May; 131(5):1421-3. Epub 2012 Nov 02.
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  3. Juskewitch JE, Enders FT, Abraham RS, Huskins WC. Novel infrastructure for sepsis biomarker research in critically ill neonates and children. Clin Transl Sci. 2013 Feb; 6(1):21-5. Epub 2013 Jan 14.
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  4. Tschumper RC, Dispenzieri A, Abraham RS, Henderson KJ, Jelinek DF. Molecular analysis of immunoglobulin genes reveals frequent clonal relatedness in double monoclonal gammopathies. Blood Cancer J. 2013; 3:e112. Epub 2013 Apr 19.
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  5. Trushin SA, Carena AA, Bren GD, Rizza SA, Dong X, Abraham RS, Badley AD. SDF-1alpha degrades whereas glycoprotein 120 upregulates Bcl-2 interacting mediator of death extralong isoform: implications for the development of T cell memory. J Immunol. 2012 Aug 15; 189(4):1835-42. Epub 2012 Jul 16.
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  6. Abraham RS. Relevance of antibody testing in patients with recurrent infections. J Allergy Clin Immunol. 2012 Aug; 130(2):558-9.e6.
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  7. Podjasek JC, Abraham RS. Autoimmune cytopenias in common variable immunodeficiency. Front Immunol. 2012; 3:189. Epub 2012 Jul 24.
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  8. Katoh N, Poshusta TL, Manske MK, Dispenzieri A, Gertz MA, Abraham RS, Ramirez-Alvarado M. A reappraisal of immunoglobulin variable gene primers and its impact on assessing clonal relationships between PB B cells and BM plasma cells in AL amyloidosis. J Clin Immunol. 2011 Dec; 31(6):1029-37. Epub 2011 Sep 10.
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  9. Parsaik AK, Bhalla T, Dong M, Rostambeigi N, Dierkhising RA, Dean P, Abraham R, Prieto M, Kremers WK, Razonable RR, Kudva YC. Epidemiology of cytomegalovirus infection after pancreas transplantation. Transplantation. 2011 Nov 15; 92(9):1044-50.
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  10. Joshi AY, Abraham RS, Snyder MR, Boyce TG. Immune evaluation and vaccine responses in Down syndrome: evidence of immunodeficiency? Vaccine. 2011 Jul 12; 29(31):5040-6. Epub 2011 May 17.
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  11. Bellavia D, Abraham RS, Pellikka PA, Dispenzieri A, Burnett JC Jr, Al-Zahrani GB, Green TD, Manske MK, Gertz MA, Miller FA Jr, Abraham TP. Utility of Doppler myocardial imaging, cardiac biomarkers, and clonal immunoglobulin genes to assess left ventricular performance and stratify risk following peripheral blood stem cell transplantation in patients with systemic light chain amyloidosis (Al). J Am Soc Echocardiogr. 2011 Apr; 24(4):444-54. Epub 2011 Feb 18.
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  12. Abraham RS. Relevance of laboratory testing for the diagnosis of primary immunodeficiencies: a review of case-based examples of selected immunodeficiencies. Clin Mol Allergy. 2011; 9:6. Epub 2011 Apr 09.
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  13. Shah KM, Pratt EL, Al-Rahawan MM, Abraham RS. Novel combination of ITGB2 mutations causing leukocyte adhesion deficiency type 1 (LAD-1). Journal of Pediatric Infectious Diseases. 2011; 6(2):141-8.
  14. Fervenza FC, Abraham RS, Erickson SB, Irazabal MV, Eirin A, Specks U, Nachman PH, Bergstralh EJ, Leung N, Cosio FG, Hogan MC, Dillon JJ, Hickson LJ, Li X, Cattran DC, Mayo Nephrology Collaborative Group. Rituximab therapy in idiopathic membranous nephropathy: a 2-year study. Clin J Am Soc Nephrol. 2010 Dec; 5(12):2188-98. Epub 2010 Aug 12.
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  15. Rostambeigi N, Kudva YC, John S, Mailankody S, Pedersen RA, Dean PG, Prieto M, Cosio FG, Kremers WK, Walker RC, Abraham RS, Stegall MD. Epidemiology of infections requiring hospitalization during long-term follow-up of pancreas transplantation. Transplantation. 2010 May 15; 89(9):1126-33.
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  16. Dong X, Hoeltzle MV, Hagan JB, Park MA, Li JT, Abraham RS. Phenotypic and clinical heterogeneity associated with monoallelic TNFRSF13B-A181E mutations in common variable immunodeficiency. Hum Immunol. 2010 May; 71(5):505-11. Epub 2010 Mar 12.
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  17. Zuckerman NS, McCann KJ, Ottensmeier CH, Barak M, Shahaf G, Edelman H, Dunn-Walters D, Abraham RS, Stevenson FK, Mehr R. Ig gene diversification and selection in follicular lymphoma, diffuse large B cell lymphoma and primary central nervous system lymphoma revealed by lineage tree and mutation analyses. Int Immunol. 2010; 22(11):863-73.
  18. Cummins NW, Deziel PJ, Abraham RS, Razonable RR. Deficiency of cytomegalovirus (CMV)-specific CD8+ T cells in patients presenting with late-onset CMV disease several years after transplantation. Transpl Infect Dis. 2009 Feb; 11(1):20-7. Epub 2008 Sep 21.
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  19. Joshi AY, Iyer VN, Boyce TG, Hagan JB, Park MA, Abraham RS. Elevated serum immunoglobulin E (IgE): when to suspect hyper-IgE syndrome-A 10-year pediatric tertiary care center experience. Allergy Asthma Proc. 2009 Jan-Feb; 30(1):23-7.
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  20. Park MA, Li JT, Hagan JB, Maddox DE, Abraham RS. Common variable immunodeficiency: a new look at an old disease. Lancet. 2008 Aug 9; 372(9637):489-502.
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  21. Shepard BD, De Forni D, McNamara DR, Foli A, Rizza SA, Abraham RS, Knutson K, Wettstein PJ, Lori F, Badley AD. Beneficial effect of TRAIL on HIV burden, without detectable immune consequences. PLoS One. 2008; 3(8):e3096. Epub 2008 Aug 28.
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  22. Martin W, Abraham R, Shanafelt T, Clark RJ, Bone N, Geyer SM, Katzmann JA, Bradwell A, Kay NE, Witzig TE. Serum-free light chain-a new biomarker for patients with B-cell non-Hodgkin lymphoma and chronic lymphocytic leukemia. Transl Res. 2007 Apr; 149(4):231-5.
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  23. Abraham RS, Manske MK, Zuckerman NS, Sohni A, Edelman H, Shahaf G, Timm MM, Dispenzieri A, Gertz MA, Mehr R. Novel analysis of clonal diversification in blood B cell and bone marrow plasma cell clones in immunoglobulin light chain amyloidosis. J Clin Immunol. 2007 Jan; 27(1):69-87. Epub 2006 Dec 28.
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  24. Abraham RS, Manske MK, Sohni A, Zuckerman NS, Edelman H, Shahaf G, Timm MM, Dispenzieri A, Gertz MA, Mehr R. Graphical quantification of B cell lineage trees reveals clonal diversification in immunoglobulin light chain amyloidosis. J Clin Immun. 2007; 27(1):69-87.
  25. Steiman-Shimony A, Edelman H, Hutzler A, Barak M, Zuckerman NS, Shahaf G, Dunn-Walters D, Stott DI, Abraham RS, Mehr R. Lineage tree analysis of immunoglobulin variable-region gene mutations in autoimmune diseases: chronic activation, normal selection. Cell Immunol. 2006 Dec; 244(2):130-6. Epub 2007 Apr 16.
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  26. Katzmann JA, Dispenzieri A, Kyle RA, Snyder MR, Plevak MF, Larson DR, Abraham RS, Lust JA, Melton LJ 3rd, Rajkumar SV. Elimination of the need for urine studies in the screening algorithm for monoclonal gammopathies by using serum immunofixation and free light chain assays. Mayo Clin Proc. 2006 Dec; 81(12):1575-8.
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  27. Manske MK, Zuckerman NS, Timm MM, Maiden S, Edelman H, Shahaf G, Barak M, Dispenzieri A, Gertz MA, Mehr R, Abraham RS. Quantitative analysis of clonal bone marrow CD19+ B cells: use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis. Clin Immunol. 2006 Jul; 120(1):106-20. Epub 2006 Mar 03.
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  28. Dispenzieri A, Lacy MQ, Katzmann JA, Rajkumar SV, Abraham RS, Hayman SR, Kumar SK, Clark R, Kyle RA, Litzow MR, Inwards DJ, Ansell SM, Micallef IM, Porrata LF, Elliott MA, Johnston PB, Greipp PR, Witzig TE, Zeldenrust SR, Russell SJ, Gastineau D, Gertz Absolute values of immunoglobulin free light chains are prognostic in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation. Blood. 2006 Apr 15; 107(8):3378-83. Epub 2006 Jan 05.
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  29. Steiman-Shimony A, Edelman H, Barak M, Shahaf G, Dunn-Walters D, Stott DI, Abraham RS, Mehr R. Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases. Journal of Autoimmunity Reviews. 2006; 5:242-251.
  30. Katzmann JA, Abraham RS, Dispenzieri A, Lust JA, Kyle RA. Diagnostic performance of quantitative kappa and lambda free light chain assays in clinical practice. Clin Chem. 2005 May; 51(5):878-81.
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  31. Abraham RS, Ballman KV, Dispenzieri A, Grill DE, Manske MK, Price-Troska TL, Paz NG, Gertz MA, Fonseca R. Functional gene expression analysis of clonal plasma cells identifies a unique molecular profile for light chain amyloidosis. Blood. 2005 Jan 15; 105(2):794-803.
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  32. Abraham RS, Geyer SM, Ramirez-Alvarado M, Price-Troska TL, Gertz MA, Fonseca R. Analysis of somatic hypermutation and antigenic selection in the clonal B cell in immunoglobulin light chain amyloidosis (AL). J Clin Immunol. 2004 Jul; 24(4):340-53.
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  33. Bergen HR, Abraham RS, Johnson KL, Bradwell AR, Naylor S. Characterization of amyloidogenic immunoglobulin light chains directly from serum by on-line immunoaffinity isolation. Biomed Chromatogr. 2004 Apr; 18(3):191-201.
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  34. Abraham RS, Geyer SM, Price-Troska TL, Allmer C, Kyle RA, Gertz MA, Fonseca R. Immunoglobulin light chain variable (V) region genes influence clinical presentation and outcome in light chain-associated amyloidosis (AL). Blood. 2003 May 15; 101(10):3801-8.
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  35. Abraham RS, Katzmann JA, Clark RJ, Bradwell AR, Kyle RA, Gertz MA. Quantitative analysis of serum free light chains - A new marker for the diagnostic evaluation of primary systemic amyloidosis. Am J Clin Pathol. 2003 Feb; 119(2):274-8.
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  36. Kudva YC, Rajagopalan G, Raju R, Abraham RS, Smart M, Hanson J, David CS. Modulation of insulitis and type 1 diabetes by transgenic HLA-DR3 and DQ8 in NOD mice lacking endogenous MHC class II. Hum Immunol. 2002 Nov; 63(11):987-99.
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  37. Abraham RS, Charlesworth MC, Owen BAL, Benson LM, Katzmann JA, Reeder CB, Kyle RA. Trimolecular complexes of lambda light chain dimers in serum of a patient with multiple myeloma. Clin Chem. 2002 Oct; 48(10):1805-11.
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  38. Katzmann JA, Clark RJ, Abraham RS, Bryant S, Lymp JF, Bradwell AR, Kyle RA. Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains. Clin Chem. 2002 Sep; 48(9):1437-44.
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  39. Peng H, Kim DI, Sarkaria JN, Cho YS, Abraham RT, Zalkow LH. Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases. Bioorg Med Chem. 2002 Jan; 10(1):167-74.
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  40. Abraham RS, Clark RJ, Bryant SC, Lymp JF, Larson T, Kyle RA, Katzmann JA. Correlation of serum immunoglobulin free light chain quantification with urinary Bence Jones protein in light chain myeloma. Clin Chem. 2002; 48(4):655-7.
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  41. Naumov YN, Bahjat KS, Gausling R, Abraham R, Exley MA, Koezuka Y, Balk SB, Strominger JL, Clare-Salzer M, Wilson SB. Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13838-43. Epub 2001 Nov 13.
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  42. Kudva YC, Deng YJ, Govindarajan R, Abraham RS, Marietta EV, Notkins AL, David CS. HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2. Hum Immunol. 2001 Oct; 62(10):1099-105.
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  43. Abraham RS, Wen L, Marietta EV, David CS. Type 1 diabetes-predisposing MHC alleles influence the selection of glutamic acid decarboxylase (GAD) 65-specific T cells in a transgenic model. J Immunol. 2001 Jan 15; 166(2):1370-9.
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  44. Sekulic A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 2000 Jul 1; 60(13):3504-13.
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  45. Busby EC, Leistritz DF, Abraham RT, Karnitz LM, Sarkaria JN. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res. 2000 Apr 15; 60(8):2108-12.
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  46. Abraham RS, Kudva YC, Wilson SB, Strominger JL, David CS. Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice. Diabetes. 2000 Apr; 49(4):548-54.
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  47. Abraham RS, David CS. Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice. Curr Opin Immunol. 2000 Feb; 12(1):122-9.
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  48. Binstadt BA, Williams BL, Abraham RT, Leibson PJ. Use of mutant Jurkat T cell lines to define human natural killer cell surface receptor signaling pathways. Methods Mol Biol. 2000; 121:297-304.
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  49. Das P, Abraham R, David C. HLA transgenic mice as models of human autoimmune diseases. Rev Immunogenet. 2000; 2(1):105-14.
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  50. Reiter TA, Abraham RT, Choi M, Rusnak F. Redox regulation of calcineurin in T-lymphocytes. J Biol Inorg Chem. 1999 Oct; 4(5):632-44.
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  51. Sarkaria JN, Busby EC, Tibbetts RS, Roos P, Taya Y, Karnitz LM, Abraham RT. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res. 1999 Sep 1; 59(17):4375-82.
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  52. Abraham RS, Wilson SB, de Souza NF Jr, Strominger JL, Munn SR, David CS. NOD background genes influence T cell responses to GAD 65 in HLA-DQ8 transgenic mice. Hum Immunol. 1999 Jul; 60(7):583-90.
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  53. Sutor SL, Vroman BT, Armstrong EA, Abraham RT, Karnitz LM. A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-Raf and A-Raf. J Biol Chem. 1999 Mar 12; 274(11):7002-10.
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  54. Jevremovic D, Billadeau DD, Schoon RA, Dick CJ, Irvin BJ, Zhang W, Samelson LE, Abraham RT, Leibson PJ. Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity. J Immunol. 1999 Mar 1; 162(5):2453-6.
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  55. Das P, Abraham RS, David CS. HLA transgenic mice as models of human autoimmune diseases. Reviews in Immunogenetics. 1999 2; 2:105-11.
  56. Tibbetts RS, Brumbaugh KM, Williams JM, Sarkaria JN, Cliby WA, Shieh SY, Taya Y, Prives C, Abraham RT. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 1999 Jan 15; 13(2):152-7.
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  57. Abraham RS, Kudva YC, Wilson SB, Strominger JL, David CS. NOD background genes influence T cell responses to GAD 65 in HLA-DQ8 transgenic mice. Diabetes. 1999; 49:548-55.
  58. Binstadt BA, Billadeau DD, Jevremovic D, Williams BL, Fang N, Yi T, Koretzky GA, Abraham RT, Leibson PJ. SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors. J Biol Chem. 1998 Oct 16; 273(42):27518-23.
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  59. Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE, Abraham RT. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res. 1998 Oct 1; 58(19):4375-82.
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  60. Kato M, Abraham RT, Okada S, Kita H. Ligation of the beta(2) integrin triggers activation and degranulation of human eosinophils. Am J Respir Cell Mol Biol. 1998 May; 18(5):675-686.
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  61. Williams BL, Schreiber KL, Zhang W, Wange RL, Samelson LE, Leibson PJ, Abraham RT. Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Mol Cell Biol. 1998 Mar; 18(3):1388-99.
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  62. Singh N, Bhatia S, Abraham RS, Basu SK, George A, Bal V, Rath S. Modulation of T cell cytokine profiles and peptide-MHC complex availability in vivo by delivery to scavenger receptors via antigen maleylation. Journal of Immunology. 1998; 160:4869-880.
  63. Eischen CM, Williams BL, Zhang W, Samelson LE, Lynch DH, Abraham RT, Leibson PJ. ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis. J Immunol. 1997 Aug 1; 159(3):1135-9.
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  64. Abraham RS, Choudhury A, Basu SK, Bal V, Rath S. Disruption of T cell tolerance by directing a self-antigen to macrophage-specific scavenger receptor. Journal of Immunology. 1997; 158:4029-35.
  65. Lim KK, Su WP, Schroeter AL, Sabers CJ, Abraham RT, Pittelkow MR. Cyclosporine in the treatment of dermatologic disease: an update. Mayo Clin Proc. 1996 Dec; 71(12):1182-91.
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  66. Binstadt BA, Brumbaugh KM, Dick CJ, Scharenberg AM, Williams BL, Colonna M, Lanier LL, Kinet JP, Abraham RT, Leibson PJ. Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity. 1996 Dec; 5(6):629-38.
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  67. Karnitz LM, Abraham RT. Interleukin-2 receptor signaling mechanisms. Adv Immunol. 1996; 61:147-99.
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  68. Abraham RS, Singh N, Mukhopadhyay A, Basu S K, Bal V, Rath, S. Modulation of immunogenicity and antigenicity of proteins by maleylation to target scavenger receptors on macrophages. Journal of Immunology. 1995; 154:1-8.


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