Publications - Liang Wang, M.D., Ph.D.

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  1. Li Y, Tang H, Sun Z, Bungum AO, Edell ES, Lingle WL, Stoddard SM, Zhang M, Jen J, Yang P, Wang L. Network-based approach identified cell cycle genes as predictor of overall survival in lung adenocarcinoma patients. Lung Cancer. 2013 Apr; 80(1):91-8. Epub 2013 Jan 26.
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  2. Pu X, Ye Y, Spitz MR, Wang L, Gu J, Lippman SM, Hildebrandt MA, Hong WK, Minna JD, Roth JA, Yang P, Wu X. Predictors of survival in never-smokers with non-small cell lung cancer: a large-scale, two-phase genetic study. Clin Cancer Res. 2012 Nov 1; 18(21):5983-91. Epub 2012 Sep 13.
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  3. Liu P, Morrison C, Wang L, Xiong D, Vedell P, Cui P, Hua X, Ding F, Lu Y, James M, Ebben JD, Xu H, Adjei AA, Head K, Andrae JW, Tschannen MR, Jacob H, Pan J, Zhang Q, Van den Bergh F, Xiao H, Lo KC, Patel J, Richmond T, Watt MA, Albert T, Selzer R, Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing. Carcinogenesis. 2012 Jul; 33(7):1270-6. Epub 2012 Apr 17.
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  4. Lu Y, Govindan R, Wang L, Liu PY, Goodgame B, Wen W, Sezhiyan A, Pfeifer J, Li YF, Hua X, Wang Y, Yang P, You M. MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer. Carcinogenesis. 2012 May; 33(5):1046-54. Epub 2012 Feb 13.
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  5. Lu Y, Wang L, Liu P, Yang P, You M. Gene-expression signature predicts postoperative recurrence in stage I non-small cell lung cancer patients. PLoS One. 2012; 7(1):e30880. Epub 2012 Jan 23.
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  6. Spitz MR, Gorlov IP, Amos CI, Dong Q, Chen W, Etzel CJ, Gorlova OY, Chang DW, Pu X, Zhang D, Wang L, Cunningham JM, Yang P, Wu X. Variants in inflammation genes are implicated in risk of lung cancer in never smokers exposed to second-hand smoke. Cancer Discov. 2011 Oct; 1(5):420-9. Epub 2011 Aug 25.
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  7. Oberg AL, French AJ, Sarver AL, Subramanian S, Morlan BW, Riska SM, Borralho PM, Cunningham JM, Boardman LA, Wang L, Smyrk TC, Asmann Y, Steer CJ, Thibodeau SN. miRNA expression in colon polyps provides evidence for a multihit model of colon cancer. PLoS One. 2011; 6(6):e20465. Epub 2011 Jun 09.
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  8. Pedersen KS, Bamlet WR, Oberg AL, de Andrade M, Matsumoto ME, Tang H, Thibodeau SN, Petersen GM, Wang L. Leukocyte DNA methylation signature differentiates pancreatic cancer patients from healthy controls. PLoS One. 2011; 6(3):e18223. Epub 2011 Mar 24.
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  9. Wang LD, Zhou FY, Li XM, Sun LD, Song X, Jin Y, Li JM, Kong GQ, Qi H, Cui J, Zhang LQ, Yang JZ, Li JL, Li XC, Ren JL, Liu ZC, Gao WJ, Yuan L, Wei W, Zhang YR, Wang WP, Sheyhidin I, Li F, Chen BP, Ren SW, Liu B, Li D, Ku JW, Fan ZM, Zhou SL, Guo ZG, Zhao Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet. 2010 Sep; 42(9):759-63. Epub 2010 Aug 22.
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  10. Wang L, Aakre JA, Jiang R, Marks RS, Wu Y, Chen J, Thibodeau SN, Pankratz VS, Yang P. Methylation markers for small cell lung cancer in peripheral blood leukocyte DNA. J Thorac Oncol. 2010 Jun; 5(6):778-85.
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  11. Li Y, Sheu CC, Ye Y, de Andrade M, Wang L, Chang SC, Aubry MC, Aakre JA, Allen MS, Chen F, Cunningham JM, Deschamps C, Jiang R, Lin J, Marks RS, Pankratz VS, Su L, Li Y, Sun Z, Tang H, Vasmatzis G, Harris CC, Spitz MR, Jen J, Wang R, Zhang ZF, Christiani Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol. 2010 Apr; 11(4):321-30. Epub 2010 Mar 19.
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  12. Wang L, Tang H, Thayanithy V, Subramanian S, Oberg AL, Cunningham JM, Cerhan JR, Steer CJ, Thibodeau SN. Gene networks and microRNAs implicated in aggressive prostate cancer. Cancer Res. 2009 Dec 15; 69(24):9490-7.
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  13. Wang L, Oberg AL, Asmann YW, Sicotte H, McDonnell SK, Riska SM, Liu W, Steer CJ, Subramanian S, Cunningham JM, Cerhan JR, Thibodeau SN. Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell lines. PLoS One. 2009; 4(6):e5878. Epub 2009 Jun 11.
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  14. Cunningham JM, Oberg AL, Borralho PM, Kren BT, French AJ, Wang L, Bot BM, Morlan BW, Silverstein KA, Staggs R, Zeng Y, Lamblin AF, Hilker CA, Fan JB, Steer CJ, Thibodeau SN. Evaluation of a new high-dimensional miRNA profiling platform. BMC Med Genomics. 2009; 2:57. Epub 2009 Aug 27.
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  15. Sarver AL, French AJ, Borralho PM, Thayanithy V, Oberg AL, Silverstein KA, Morlan BW, Riska SM, Boardman LA, Cunningham JM, Subramanian S, Wang L, Smyrk TC, Rodrigues CM, Thibodeau SN, Steer CJ. Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states. BMC Cancer. 2009; 9:401. Epub 2009 Nov 18.
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  16. Wang L, McDonnell SK, Hebbring SJ, Cunningham JM, St Sauver J, Cerhan JR, Isaya G, Schaid DJ, Thibodeau SN. Polymorphisms in mitochondrial genes and prostate cancer risk. Cancer Epidemiol Biomarkers Prev. 2008 Dec; 17(12):3558-66.
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  17. Halfdanarson TR, Wang L, Bamlet WR, de Andrade M, McWilliams RR, Cunningham JM, Petersen GM. Mitochondrial genetic polymorphisms do not predict survival in patients with pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2008 Sep; 17(9):2512-3.
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  18. Friday BB, Yu C, Dy GK, Smith PD, Wang L, Thibodeau SN, Adjei AA. BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins. Cancer Res. 2008 Aug 1; 68(15):6145-53.
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  19. Gudmundsson J, Sulem P, Rafnar T, Bergthorsson JT, Manolescu A, Gudbjartsson D, Agnarsson BA, Sigurdsson A, Benediktsdottir KR, Blondal T, Jakobsdottir M, Stacey SN, Kostic J, Kristinsson KT, Birgisdottir B, Ghosh S, Magnusdottir DN, Thorlacius S, Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat Genet. 2008 Mar; 40(3):281-3. Epub 2008 Feb 10.
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  20. Johanneson B, McDonnell SK, Karyadi DM, Hebbring SJ, Wang L, Deutsch K, McIntosh L, Kwon EM, Suuriniemi M, Stanford JL, Schaid DJ, Ostrander EA, Thibodeau SN. Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb. Hum Genet. 2008 Feb; 123(1):65-75. Epub 2007 Dec 08.
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  21. Zou H, Harrington JJ, Shire AM, Rego RL, Wang L, Campbell ME, Oberg AL, Ahlquist DA. Highly methylated genes in colorectal neoplasia: implications for screening. Cancer Epidemiol Biomarkers Prev. 2007 Dec; 16(12):2686-96.
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  22. Riegert-Johnson DL, Johnson RA, Rabe KG, Wang L, Thomas B, Baudhuin LM, Thibodeau SN, Boardman LA. The value of MUTYH testing in patients with early onset microsatellite stable colorectal cancer referred for hereditary nonpolyposis colon cancer syndrome testing. Genet Test. 2007 Winter; 11(4):361-5.
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  23. Wang L, Bamlet WR, de Andrade M, Boardman LA, Cunningham JM, Thibodeau SN, Petersen GM. Mitochondrial genetic polymorphisms and pancreatic cancer risk. Cancer Epidemiol Biomarkers Prev. 2007 Jul; 16(7):1455-9.
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  24. Cunningham JM, Hebbring SJ, McDonnell SK, Cicek MS, Christensen GB, Wang L, Jacobsen SJ, Cerhan JR, Blute ML, Schaid DJ, Thibodeau SN. Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer. Cancer Epidemiol Biomarkers Prev. 2007 May; 16(5):969-78.
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  25. Boardman LA, Johnson RA, Petersen GM, Oberg AL, Kabat BF, Slusser JP, Wang L, Morlan BW, French AJ, Smyrk TC, Lindor NM, Thibodeau SN. Higher frequency of diploidy in young-onset microsatellite-stable colorectal cancer. Clin Cancer Res. 2007 Apr 15; 13(8):2323-8.
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  26. Wang L, McDonnell SK, Slusser JP, Hebbring SJ, Cunningham JM, Jacobsen SJ, Cerhan JR, Blute ML, Schaid DJ, Thibodeau SN. Two common chromosome 8q24 variants are associated with increased risk for prostate cancer. Cancer Res. 2007 Apr 1; 67(7):2944-50.
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  27. Wang X, Wang F, Taniguchi K, Seelan RS, Wang L, Zarfas KE, McDonnell SK, Qian C, Pan K, Lu Y, Shridhar V, Couch FJ, Tindall DJ, Beebe-Dimmer JL, Cooney KA, Isaacs WB, Jacobsen SJ, Schaid DJ, Thibodeau SN, Liu W. Truncating variants in p53AIP1 disrupting DNA damage-induced apoptosis are associated with prostate cancer risk. Cancer Res. 2006 Nov 1; 66(21):10302-7.
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  28. Domingo E, Laiho P, Ollikainen M, Pinto M, Wang L, French AJ, Westra J, Frebourg T, Espin E, Armengol M, Hamelin R, Yamamoto H, Hofstra RM, Seruca R, Lindblom A, Peltomaki P, Thibodeau SN, Aaltonen LA, Schwartz S Jr. BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing. J Med Genet. 2004 Sep; 41(9):664-8.
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  29. Wang L, Baudhuin LM, Boardman LA, Steenblock KJ, Petersen GM, Halling KC, French AJ, Johnson RA, Burgart LJ, Rabe K, Lindor NM, Thibodeau SN. MYH mutations in patients with attenuated and classic polyposis and with young-onset colorectal cancer without polyps. Gastroenterology. 2004 Jul; 127(1):9-16.
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  30. Wang L, McDonnell SK, Cunningham JM, Hebbring S, Jacobsen SJ, Cerhan JR, Slager SL, Blute ML, Schaid DJ, Thibodeau SN. No association of germline alteration of MSR1 with prostate cancer risk. Nat Genet. 2003 Oct; 35(2):128-9. Epub 2003 Sep 07.
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  31. Hahnloser D, Petersen GM, Rabe K, Snow K, Lindor NM, Boardman L, Koch B, Doescher D, Wang L, Steenblock K, Thibodeau SN. The APC E1317Q variant in adenomatous polyps and colorectal cancers. Cancer Epidemiol Biomarkers Prev. 2003 Oct; 12(10):1023-8.
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  32. Wang L, Cunningham JM, Winters JL, Guenther JC, French AJ, Boardman LA, Burgart LJ, McDonnell SK, Schaid DJ, Thibodeau SN. BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair. Cancer Res. 2003 Sep 1; 63(17):5209-12.
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  33. Slager SL, Schaid DJ, Wang L, Thibodeau SN. Candidate-gene association studies with pedigree data: controlling for environmental covariates. Genet Epidemiol. 2003 May; 24(4):273-83.
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  34. Dong X, Wang L, Taniguchi K, Wang X, Cunningham JM, McDonnell SK, Qian C, Marks AF, Slager SL, Peterson BJ, Smith DI, Cheville JC, Blute ML, Jacobsen SJ, Schaid DJ, Tindall DJ, Thibodeau SN, Liu W. Mutations in CHEK2 associated with prostate cancer risk. Am J Hum Genet. 2003 Feb; 72(2):270-80. Epub 2003 Jan 17.
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  35. Wang L, McDonnell SK, Elkins DA, Slager SL, Christensen E, Marks AF, Cunningham JM, Peterson BJ, Jacobsen SJ, Cerhan JR, Blute ML, Schaid DJ, Thibodeau SN. Analysis of the RNASEL gene in familial and sporadic prostate cancer. Am J Hum Genet. 2002 Jul; 71(1):116-23. Epub 2002 May 17.
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  36. Zhang JS, Wang L, Huang H, Nelson M, Smith DI. Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells. Genes Chromosomes Cancer. 2001 Feb; 30(2):123-35.
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  37. Wang L, McDonnell SK, Elkins DA, Slager SL, Christensen E, Marks AF, Cunningham JM, Peterson BJ, Jacobsen SJ, Cerhan JR, Blute ML, Schaid DJ, Thibodeau SN. Role of HPC2/ELAC2 in familial prostate cancer. Cancer Res. 2001; 61(17):6494-9.
  38. McIver B, Grebe SK, Wang L, Hay ID, Yokomizo A, Liu W, Goellner JR, Grant CS, Smith DI, Eberhardt NL. FHIT and TSG101 in thyroid tumours: aberrant transcripts reflect rare abnormal RNA processing events of uncertain pathogenetic or clinical significance. Clin Endocrinol (Oxf). 2000 Jun; 52(6):749-57.
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  39. Wang L, Darling J, Zhang JS, Liu W, Qian J, Bostwick D, Hartmann L, Jenkins R, Bardenhauer W, Schutte J, Opalka B, Smith DI. Loss of expression of the DRR 1 gene at chromosomal segment 3p21.1 in renal cell carcinoma. Genes Chromosomes Cancer. 2000 Jan; 27(1):1-10.
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  40. Parc YR, Halling KC, Wang L, Christensen ER, Cunningham JM, Burgart LJ, Price-Troska TL, Thibodeau SN. hMSH6 Alterations in Patients with MSI-L Colorectal Cancer. Cancer Res. 2000; 60(8):2225-31.
  41. Huang H, Reed CP, Zhang JS, Shridhar V, Wang L, Smith DI. Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells. Cancer Res. 1999 Jun 15; 59(12):2981-8.
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  42. Wang L, Darling J, Zhang JS, Huang H, Liu W, Smith DI. Allele-specific late replication and fragility of the most active common fragile site, FRA3B. Hum Mol Genet. 1999 Mar; 8(3):431-7.
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  43. Huang H, Reed CP, Mordi A, Lomberk G, Wang L, Shridhar V, Hartmann L, Jenkins R, Smith DI. Frequent deletions within FRA7G at 7q31.2 in invasive epithelial ovarian cancer. Genes Chromosomes Cancer. 1999 Jan; 24(1):48-55.
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  44. Zhang JS, Nelson M, Wang L, Liu W, Qian CP, Shridhar V, Urrutia R, Smith DI. Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin. Genomics. 1998 Nov 15; 54(1):149-54.
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  45. Wang L, Darling J, Zhang JS, Qian CP, Hartmann L, Conover C, Jenkins R, Smith DI. Frequent homozygous deletions in the FRA3B region in tumor cell lines still leave the FHIT exons intact. Oncogene. 1998 Feb 5; 16(5):635-42.
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  46. Smith DI, Huang H, Wang L. Common fragile sites and cancer (review). Int J Oncol. 1998 Jan; 12(1):187-96.
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  47. Wang L, Zhu D, Zhang C, Mao X, Wang G, Mitra S, Li BF, Wang X, Wu M. Mutations of O6-methylguanine-DNA methyltransferase gene in esophageal cancer tissues from Northern China. Int J Cancer. 1997 May 29; 71(5):719-23.
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  48. Wang L, Paradee W, Mullins C, Shridhar R, Rosati R, Wilke CM, Glover TW, Smith DI. Aphidicolin-induced FRA3B breakpoints cluster in two distinct regions. Genomics. 1997 May 1; 41(3):485-8.
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  49. Shridhar V, Wang L, Rosati R, Paradee W, Shridhar R, Mullins C, Sakr W, Grignon D, Miller OJ, Sun QC, Petros J, Smith DI. Frequent breakpoints in the region surrounding FRA3B in sporadic renal cell carcinomas. Oncogene. 1997 Mar 20; 14(11):1269-77.
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  50. Paradee W, Wilke CM, Wang L, Shridhar R, Mullins CM, Hoge A, Glover TW, Smith DI. A 350-kb cosmid contig in 3p14.2 that crosses the t(3;8) hereditary renal cell carcinoma translocation breakpoint and 17 aphidicolin-induced FRA3B breakpoints. Genomics. 1996 Jul 1; 35(1):87-93.
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  51. Wang L, Li W, Wang X, Zhang C, Zhang T, Mao X, Wu M. Genetic alterations on chromosomes 3 and 9 of esophageal cancer tissues from China. Oncogene. 1996 Feb 1; 12(3):699-703.
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  52. Li W, Wang L, Wang X, et al. Chromosome loci-specific loss of heterozygosity and microsatellite instability in esophageal cancer tissues. Chin J Med Genet. 1996; 13(4):194-7.
  53. Wang L, Wu M. Advances on PCR-based detection of gene mutations. Chinese J Med Genet. 1995; 12(1):30-3.
  54. Zhu D, Yan S, Wang L, Wu M. Detection of gene amplifications in a small amount of samples by RPSB hybridization method. High Technol Lett. 1994; 4:1-3.
  55. Zhu D, Wang L, Wu M. Screening for point mutations of p53 gene in esophageal cancers by PCR-SSCP silver staining Method. Chinese J Med Genet. 1994; 11(6):354-5.
  56. Wang L, Zhang J, Wu M. Rapid and reliable sequencing protocol for PCR products. Biochem Biophys. 1994; 21(5):459-60.
  57. Wang L, Wu M. O6-methylguanine-DNA methyltransferase and tumors. Adv Med Sci (Section of Tumor) 1994; 21(3):129-31.
  58. Wang L, Wu M. Human DNA repair genes. Adv Med Sci (Section of Genetics) 1994; 17:61-5.
  59. Wang L, You W, Liu Y, et al. Hot chromosomal breakpoints of lymphocyte in patients with esophageal cancer correlated with fragile sites, neoplasia-associated breakpoints and oncogene sites. Hered Dis. 1990; 7(3):158-61.
  60. Wang L, Geng T, Liu Y, et al. Exfoliated cell micronuclei in patients with esophageal cancer. Hereditas (Beijing) 1989; 11:35-6.


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