Publications - Liewei Wang, M.D., Ph.D.

Back to Research Profile

1. Fridley BL, Jenkins G, Schaid DJ, Wang L. A Bayesian hierarchical nonlinear model for assessing the association between genetic variation and drug cytotoxicity. Stat Med 2009 Sep 20; 28(21):2709-22.
   View PubMed
2. Pei H, Li L, Fridley BL, Jenkins GD, Kalari KR, Lingle W, Petersen G, Lou Z, Wang L. FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell 2009 Sep 8; 16(3):259-66.
   View PubMed
3. Aksoy P, Zhu MJ, Kalari KR, Moon I, Pelleymounter LL, Eckloff BW, Wieben ED, Yee VC, Weinshilboum RM, Wang L. Cytosolic 5'-nucleotidase III (NT5C3): gene sequence variation and functional genomics. Pharmacogenet Genomics 2009 Aug; 19(8):567-76.
   View PubMed
4. Niu N, Manickam V, Kalari KR, Moon I, Pelleymounter LL, Eckloff BW, Wieben ED, Schaid DJ, Wang L. Human glucocorticoid receptor alpha gene (NR3C1) pharmacogenomics: gene resequencing and functional genomics. J Clin Endocrinol Metab 2009 Aug; 94(8):3072-84. Epub 2009 May 12.
   View PubMed
5. Aksoy P, Zhu MJ, Kalari KR, Moon I, Pelleymounter LL, Eckloff BW, Wieben ED, Yee VC, Weinshilboum RM, Wang L. Cytosolic 5’-nucleotidease III (NT5C3) gene sequence variation and functional genomics: cytosine arabinoside and gemcitabine pharmacogenetics. Pharmacogenetics and Genomics in press 2009.
   View PubMed
6. Li L, Fridley BL, Kalari K, Jenkins G, Batzler A, Weinshilboum RM, Wang L. Gemcitabine and arabinosylcytosin pharmacogenomics: genome-wide association and drug response biomarkers. PLoS One 2009; 4(11):e7765. Epub 2009 Nov 09.
   View PubMed
7. Pei H, Li L, Fridley B, Jenkins G, Kalari R, Lingle W, Petersen G, Lou Z, Wang L. FKBP51 acts as a scaffolding protein to regulate Akt phosphorylation. Cancer Cell , In press 2009.
   View PubMed
8. Li F, Wang L, Burgess RJ, Weinshilboum RM. Thiopurine S-methyltransferase pharmacogenetics: autophagy as a mechanism for variant allozyme degradation. Pharmacogenet Genomics 2008 Dec; 18(12):1083-94.
   View PubMed
9. Wang L, Weinshilboum RM. Pharmacogenomics: candidate gene identification, functional validation and mechanisms. Hum Mol Genet 2008 Oct 15; 17(R2):R174-9.
   View PubMed
10. Li L, Fridley B, Kalari K, Jenkins G, Batzler A, Safgren S, Hildebrandt M, Ames M, Schaid D, Wang L. Gemcitabine and cytosine arabinoside cytotoxicity: association with lymphoblastoid cell expression. Cancer Res 2008 Sep 1; 68(17):7050-8.
    View PubMed
11. Yu Z, Wang L, Hildebrandt MA, Schaid DJ. Testing whether genetic variation explains correlation of quantitative measures of gene expression, and application to genetic network analysis. Stat Med 2008 Aug 30; 27(19):3847-67.
    View PubMed
12. Ji Y, Olson J, Zhang J, Hildebrandt M, Wang L, Ingle J, Fredericksen Z, Sellers T, Miller W, Dixon JM, Brauch H, Eichelbaum M, Justenhoven C, Hamann U, Ko Y, Bruning T, Chang-Claude J, Wang-Gohrke S, Schaid D, Weinshilboum R. Breast cancer risk reduction and membrane-bound catechol O-methyltransferase genetic polymorphisms. Cancer Res 2008 Jul 15; 68(14):5997-6005.
    View PubMed
13. Wang L, Kumar S, Fridley BL, Kalari KR, Moon I, Pelleymounter LL, Hildebrandt MA, Batzler A, Eckloff BW, Wieben ED, Greipp PR. Proteasome beta subunit pharmacogenomics: gene resequencing and functional genomics. Clin Cancer Res 2008 Jun 1; 14(11):3503-13.
    View PubMed
14. Wang L, Salavaggione E, Pelleymounter L, Eckloff B, Wieben E, Weinshilboum R. Human 3beta-hydroxysteroid dehydrogenase types 1 and 2: Gene sequence variation and functional genomics. J Steroid Biochem Mol Biol 2007 Oct; 107(1-2):88-99. Epub 2007 Jun 08.
    View PubMed
15. Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V, Roden DM, Schaefer CA, Shuldiner AR, Skaar T, Tantisira K, Tyndale RF, Wang L The pharmacogenetics research network: from SNP discovery to clinical drug response. Clin Pharmacol Ther 2007 Mar; 81(3):328-45.
    View PubMed
16. Wood TC, Salavagionne OE, Mukherjee B, Wang L, Klumpp AF, Thomae BA, Eckloff BW, Schaid DJ, Wieben ED, Weinshilboum RM. Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies. J Biol Chem 2006 Mar 17; 281(11):7364-73. Epub 2006 Jan 06.
    View PubMed
17. Weinshilboum RM, Wang L. Pharmacogenetics and pharmacogenomics: development, science, and translation. Annu Rev Genomics Hum Genet 2006; 7:223-45.
    View PubMed
18. Wang L, Weinshilboum R. Thiopurine S-methyltransferase (TPMT) pharmacogenetics: a model for clinical and mechanistic pharmacogenetics studies. Oncogene 2006:1629-38.
19. Ji Y, Salavaggione OE, Wang LW, Adjei AA, Eckloff B, Wieben ED, Weinshilboum RM. Human phenylethanolamine N-methyltransferase pharmacogenomics: gene re-sequencing and functional genomics. J Neurochem 2005 Dec; 95(6):1766-76.
    View PubMed
20. Salavaggione OE, Wang LW, Wiepert M, Yee VC, Weinshilboum RM. Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics. Pharmacogenet Genomics 2005 Nov; 15(11):801-5.
    View PubMed
21. Wang L, Nguyen TV, McLaughlin RW, Sikkink LA, Ramirez-Alvarado M, Weinshilboum RM. Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation. Proc Natl Acad Sci U S A 2005 Jun 28; 102(26):9394-9.
    View PubMed
22. Ma CX, Adjei AA, Salavaggione OE, Pelleymounter L, Wang L, Eckloff BW, Schaid D, Wieben ED, Adjei Weinshilboum RM. Human aromatase (CYP19) pharmacogenomics: gene resequencing and functional genomics. Cancer Res 2005; 65:11071-82.
    View PubMed
23. Weinshilboum R, Wang LW. Pharmacogenomics: Bench to bedside. Nature Reviews. Drug Discovery 2004 Sep; 3(9):739-48.
    View PubMed
24. Weinshilboum R, Wang L. Pharmacogenomics: bench to bedside. Nature Rev Drug Discovery 2004 3; Nature Rev Drug Discovery 2004 3:739-748.
    View PubMed
25. Weinshilboum R, Wang L. Pharmacogenetics: inherited variation in amino acid sequence and altered protein quantity. Clin Pharmacol Ther 2004; Clin Pharmacol Ther 2004 75:253-258.
    View PubMed
26. Weinshilboum R, Wang L. Pharmacogenetics: inherited variation in amino acid sequence and altered protein quantity. Clin Pharmacol Ther 2004; Clin Pharmacol Ther 2004 75:253-258.
    View PubMed
27. Wang L, Yee VC, Weinshilboum RM. Human sulfotransferase (SULT1A3) pharmacogenetics: a model system for aggresome formation and accelerated degradation. Biochem Biophys Res Commun 2004; 325:426-33.
    View PubMed
28. Wang L, Sullivan W, Toft D, Weinshilboum R. Thiopurine S-methyltransferase pharmacogenetics: chaperone protein association and allozyme degradation. Pharmacogenetics 2003 Sep; 13(9):555-64.
    View PubMed
29. Salavaggione OE, Kidd L, Prondzinski JL, Szumlanski CL, Pankratz VS, Wang L, Trepanier L, Weinshilboum RM. Canine red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics. Pharmacogenetics 2002 Dec; 12(9):713-24.
    View PubMed
30. Wang L, Thomae B, Eckloff B, Wieben E, Weinshilboum R. Human histamine N-methyltransferase pharmacogenetics: gene resequencing, promoter characterization, and functional studies of a common 5 '-flanking region single nucleotide polymorphism (SNP). Biochem Pharmacol 2002 Aug 15; 64(4):699-710.
    View PubMed
31. Wang L, Yan L, McGuire C, Kozak CA, Wang M, Kim UJ, Siciliano M, Weinshilboum RM. Mouse histamine N-methyltransferase: cDNA cloning, expression, gene cloning and chromosomal localization. Inflamm Res 2001 Jun; 50(6):300-8.
    View PubMed
32. Holmuhamedov EL, Wang L, Terzic A. ATP-sensitive K+ channel openers prevent Ca2+ overload in rat cardiac mitochondria. J Physiol 1999 Sep 1; 519 Pt 2:347-60.
    View PubMed