Publications - Haidong Dong, M.D., Ph.D.

Back to Research Profile

1. Gong AY, Zhou R, Hu G, Liu J, Sosnowska D, Drescher KM, Dong H, Chen XM. Cryptosporidium parvum Induces B7-H1 Expression in Cholangiocytes by Down-Regulating MicroRNA-513. J Infect Dis 2009 Nov 16. [Epub ahead of print]
   View PubMed
2. Pulko V, Liu X, Krco CJ, Harris KJ, Frigola X, Kwon ED, Dong H. TLR3-stimulated dendritic cells up-regulate B7-H1 expression and influence the magnitude of CD8 T cell responses to tumor vaccination. J Immunol 2009 Sep 15; 183(6):3634-41. Epub 2009 Aug 26.
   View PubMed
3. Wilcox RA, Feldman AL, Wada DA, Yang ZZ, Comfere NI, Dong H, Kwon ED, Novak AJ, Markovic SN, Pittelkow MR, Witzig TE, Ansell SM. B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Blood 2009 Sep 3; 114(10):2149-58. Epub 2009 Jul 13.
   View PubMed
4. Crispen PL, Sheinin Y, Roth TJ, Lohse CM, Kuntz SM, Frigola X, Thompson RH, Boorjian SA, Dong H, Leibovich BC, Blute ML, Kwon ED. Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma. Clin Cancer Res 2008 Aug 15; 14(16):5150-7. Epub 2008 Aug 11.
   View PubMed
5. Webster WS, Thompson RH, Harris KJ, Frigola X, Kuntz S, Inman BA, Dong H. Targeting molecular and cellular inhibitory mechanisms for improvement of antitumor memory responses reactivated by tumor cell vaccine. J Immunol 2007 Sep 1; 179(5):2860-9.
   View PubMed
6. Inman BA, Sebo TJ, Frigola X, Dong H, Bergstralh EJ, Frank I, Fradet Y, Lacombe L, Kwon ED. PD-L1 (B7-H1) expression by urothelial carcinoma of the bladder and BCG-induced granulomata: associations with localized stage progression. Cancer 2007 Apr 15; 109(8):1499-505.
   View PubMed
7. Siddiqui SA, Frigola X, Bonne-Annee S, Mercader M, Kuntz SM, Krambeck AE, Sengupta S, Dong H, Cheville JC, Lohse CM, Krco CJ, Webster WS, Leibovich BC, Blute ML, Knutson KL, Kwon ED. Tumor-infiltrating Foxp3-CD4+CD25+ T cells predict poor survival in renal cell carcinoma. Clin Cancer Res 2007 Apr 1; 13(7):2075-81.
   View PubMed
8. Siddiqui SA, Frigola X, Bonne-Annee S, Mercader M, Kuntz SM, Krambeck AE, Sengupta S, Dong H, Cheville JC, Lohse CM, Krco CJ, Webster WS, Leibovich BC, Blute ML, Knutson KL, Kwon ED. Tumor-infiltrating Foxp3-CD4+CD25+ T cells predict poor survival in renal cell carcinoma. Clin Cancer Res 2007 Apr 1; 13(7):2075-81.
   View PubMed
9. Krambeck AE, Dong H, Thompson RH, Kuntz SM, Lohse CM, Leibovich BC, Blute ML, Sebo TJ, Cheville JC, Parker AS, Kwon ED. Survivin and b7-h1 are collaborative predictors of survival and represent potential therapeutic targets for patients with renal cell carcinoma. Clin Cancer Res 2007 Mar 15; 13(6):1749-56.
   View PubMed
10. Inman BA, Frigola X, Dong H, Kwon ED. Costimulation, coinhibition and cancer. Curr Cancer Drug Targets 2007 Feb; 7(1):15-30.
    View PubMed
11. Zhang X, Dong H, Lin W, Voss S, Hinkley L, Westergren M, Tian G, Berry D, Lewellen D, Vile RG, Chen L, Farber DL, Strome SE. Human bone marrow: a reservoir for "enhanced effector memory" CD8+ T cells with potent recall function. J Immunol 2006 Nov 15; 177(10):6730-7.
    View PubMed
12. Zhang XY, Dong HD, Lin W, Voss S, Hinkley L, Westergren M, Tian GL, Berry D, Lewallen D, Vile RG, Chen LP, Farber DL, Strome SE. Human bone marrow: A reservoir for "enhanced effector memory" CD8(+) T cells with potent recall function. J Immunol 2006 Nov 15; 177(10):6730-7.
    View PubMed
13. Krambeck AE, Thompson RH, Dong HD, Lohse CM, Park ES, Kuntz SM, Leibovich BC, Blute ML, Cheville JC, Kwon ED. B7-H4 expression in renal cell carcinoma and tumor vasculature: Associations with cancer progression and survival. Proc Natl Acad Sci U S A 2006 Jul 5; 103(27):10391-6.
    View PubMed
14. Webster WS, Lohse CM, Thompson RH, Dong H, Frigola X, Dicks DL, Sengupta S, Frank I, Leibovich BC, Blute ML, Cheville JC, Kwon ED. Mononuclear cell infiltration in clear-cell renal cell carcinoma independently predicts patient survival. Cancer 2006 Jul 1; 107(1):46-53.
    View PubMed
15. Dong H, Chen X. Immunoregulatory role of B7-H1 in chronicity of inflammatory responses. Cell Mol Immunol 2006 Jun; 3(3):179-87.
    View PubMed
16. Thompson RH, Kuntz SM, Leibovich BC, Dong H, Lohse CM, Webster WS, Sengupta S, Frank I, Parker AS, Zincke H, Blute ML, Sebo TJ, Cheville JC, Kwon ED. Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res 2006 Apr 1; 66(7):3381-5.
    View PubMed
17. Tamura H, Dan K, Tamada K, Nakamura K, Shioi Y, Hyodo H, Wang SD, Dong HD, Chen LP, Ogata K. Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia. Clin Cancer Res 2005 Aug 15; 11(16):5708-17.
    View PubMed
18. Roden AC, Moser MT, Tri SD, Mercader M, Kuntz SM, Dong H, Hurwitz AA, McKean DJ, Celis E, Leibovich BC, Allison JP, Kwon ED. Augmentation of T cell levels and responses induced by androgen deprivation. J Immunol 2004 Nov 15; 173(10):6098-108.
    View PubMed
19. Luo LQ, Chapoval AI, Flies DB, Zhu GF, Hirano F, Wang SD, Lau JS, Dong HD, Tamada K, Flies AS, Liu Y, Chen LP. B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8(+) cytolytic T cells. J Immunol 2004 Nov 1; 173(9):5445-50.
    View PubMed
20. Dong HD, Zhu GF, Tamada K, Flies DB, van Deursen JMA, Chen LP. B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes. Immunity 2004 Mar; 20(3):327-36.
    View PubMed
21. Tamura H, Ogata K, Dong H, Chen L. Immunology of B7-H1 and its roles in human diseases. Int J Hematol 2003 Nov; 78(4):321-8.
    View PubMed
22. Strome SE, Dong HD, Tamura H, Voss SG, Flies DB, Tamada K, Salomao D, Cheville J, Hirano F, Lin W, Kasperbauer JL, Ballman KV, Chen LP. B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma. Cancer Res 2003 Oct 1; 63(19):6501-5.
    View PubMed
23. Wang SD, Bajorath J, Flies DB, Dong HD, Honjo T, Chen LP. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J Exp Med 2003 May 5; 197(9):1083-91.
    View PubMed
24. Dong HD, Chen LP. B7-H1 pathway and its role in the evasion of tumor immunity. J Mol Med 2003 May; 81(5):281-7.
    View PubMed
25. Curiel TJ, Wei S, Dong HD, Alvarez X, Cheng P, Mottram P, Krzysiek R, Knutson KL, Daniel B, Zimmermann MC, David O, Burow M, Gordon A, Dhurandhar N, Myers L, Berggren R, Hemminki A, Alvarez RD, Emilie D, Curiel DT, Chen LP, Zou WP. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med 2003 May; 9(5):562-7.
    View PubMed
26. Radhakrishnan S, Nguyen LT, Ciric B, Ure DR, Zhou B, Tamada K, Dong H, Tseng SY, Shin T, Pardoll DM, Chen LP, Kyle RA, Rodriguez M, Pease LR. Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells. J Immunol 2003 Feb 15; 170(4):1830-8.
    View PubMed
27. Dong HD, Strome SE, Matteson EL, Moder KG, Flies DB, Zhu GF, Tamura H, Driscoll CLW, Chen LP. Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis. J Clin Invest 2003 Feb; 111(3):363-70.
    View PubMed
28. Tamura H, Ogata K, Dong H, Chen L. Immunology of B7-H1 and its roles in human diseases. Int J Hematol 2003; 78:321-8.
    View PubMed
29. Trabattoni D, Saresella M, Biasin M, Boasso A, Piacentini L, Ferrante P, Dong H, Maserati R, Shearer GM, Chen L, Clerici M. B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression Blood 2003; 2003 Apr 1;101(7):2514-20. Epub 2002 Dec 5
    View PubMed
30. Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche PC, Lu J, Zhu G, Tamada K, Lennon VA, Celis E, Chen L. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002 Aug; 8(8):793-800.
    View PubMed
31. Tamura H, Dong H, Zhu G, Sica GL, Flies DB, Tamada K, Chen L. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 2001 Mar 15; 97(6):1809-16.
    View PubMed
32. Chapoval AI, Ni J, Lau JS, Wilcox RA, Flies DB, Liu D, Dong H, Sica GL, Zhu G, Tamada K, Chen L. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol 2001 Mar; 2(3):269-74.
    View PubMed
33. Wang S, Zhu G, Chapoval AI, Dong H, Tamada K, Ni J, Chen L. Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood 2000 Oct 15; 96(8):2808-13.
    View PubMed
34. Shinagawa T, Dong HD, Xu M, Maekawa T, Ishii S. The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice. EMBO J 2000 May 15; 19(10):2280-91.
    View PubMed
35. Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 1999 Dec; 5(12):1365-9.
    View PubMed
36. Nomura T, Khan MM, Kaul SC, Dong HD, Wadhwa R, Colmenares C, Kohno I, Ishii S. Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Genes Dev 1999 Feb 15; 13(4):412-23.
    View PubMed
37. Dong H, Chen J, Chen W. Membrane molecules in induction of apoptosis of thymocytes by thymic medullar dendritic cells which express Fas ligand. Science in China 1998; 41(2):189-94.
38. Dong HD, Kimoto Y, Takai S, Taguchi T. Apoptosis as a mechanism of lectin-dependent monocyte-mediated cytotoxicity. Immunol Invest 1996 Jan-Mar; 25(1-2):65-78.
    View PubMed
39. Dong H, Xing R, Guo L, Yang C, Qian Z. Apoptosis of tumor cells in lectin-dependent lymphokine-activated killer cell-mediated cytotoxicity. J Cancer Res 1996; 8(1):14-8.
40. Dong H, Wang X, Shen J, Qian Z. Effect of pokeweed mitogen on the expression of HLA-DR antigen on human monocytes and leukemia cells. J Immunol 1996; 12(4):218-21.
41. Dong H, Xing R, Guo L. [Apoptosis of tumor cells in lectin-dependent lymphokine-activated killer cell-mediated cytotoxicity]. [Chinese]. Chung-Hua Chung Liu Tsa Chih [Chinese Journal of Oncology] 1995 Jul; 17(4):245-8.
    View PubMed
42. Dong HD, Kimoto Y, Taguchi T. Pokeweed mitogen induces p55 interleukin-2 receptor expression on human monocytes and its effect on interleukin-2 activated monocyte cytotoxicity. Immunol Invest 1992 Dec; 21(7):663-70.
    View PubMed
43. Dong H, Zhao Y, Fu T, Yu L, Qian Z. Preliminary studies on the function of macrophages in different immune-deficient mice. J Immunol 1992; 8:96-8.
44. Dong H, Qian Z. In vitro and in vivo anti-tumor activity of cytokine-activated murine macrophages (CAM). Shanghai Journal of Immunology 1991; 11(5):264-7.