Publications - Richard J . Bram, M.D., Ph.D.

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1. Lee JJ, Rauter I, Garibyan L, Ozcan E, Sannikova T, Dillon SR, Cruz AC, Siegel RM, Bram R, Jabara H, Geha RS. The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function. Blood 2009 Sep 10; 114(11):2254-62.
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2. Lee JJ, Rauter I, Garibyan L, Ozcan E, Sannikova T, Dillon SR, Cruz AC, Siegel RM, Bram R, Jabara H, Geha RS. The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function. Blood 2009 Sep 10; 114(11):2254-62.
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3. Ozcan E, Garibyan L, Lee JJY, Bram RJ, Lam KP, Geha RS. Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells. J Allergy Clin Immunol 2009 Jun; 123(6):1277-86.
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4. Liu Y, Malureanu L, Jeganathan KB, Tran DD, Lindquist LD, van Deursen JM, Bram RJ. CAML loss causes anaphase failure and chromosome missegregation. Cell Cycle 2009 Mar 15; 8(6):940-9. Epub 2009 Mar 26.
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5. Kanswal S, Katsenelson N, Selvapandiyan A, Bram RJ, Akkoyunlu M. Deficient TACI expression on B lymphocytes of newborn mice leads to defective Ig secretion in response to BAFF or APRIL. J Immunol 2008 Jul 15; 181(2):976-90.
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6. Varthakavi V, Heimann-Nichols E, Smith RM, Sun Y, Bram RJ, Ali S, Rose J, Ding L, Spearman P. Identification of calcium-modulating cyclophilin ligand as a human host restriction to HIV-1 release overcome by Vpu. Nat Med 2008 Jun; 14(6):641-7. Epub 2008 May 25.
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7. Yuan X, Yao J, Norris D, Tran DD, Bram RJ, Chen G, Luscher B. Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors. Mol Cell Neurosci 2008 Jun; 38(2):277-89. Epub 2008 Mar 13.
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8. Mantchev GT, Cortesao CS, Rebrovich M, Cascalho M, Bram RJ. TACI is required for efficient plasma cell differentiation in response to T-independent type 2 antigens. J Immunol 2007 Aug 15; 179(4):2282-8.
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9. Treml LS, Carlesso G, Hoek KL, Stadanlick JE, Kambayashi T, Bram RJ, Cancro MP, Khan WN. TLR stimulation modifies BLyS receptor expression in follicular and marginal zone B cells. J Immunol 2007 Jun 15; 178(12):7531-9.
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10. Murali NS, Ackerman AW, Croatt AJ, Cheng J, Grande JP, Sutor SL, Bram RJ, Bren GD, Badley AD, Alam J, Nath KA. Renal upregulation of HO-1 reduces albumin-driven MCP-1 production: implications for chronic kidney disease. Am J Physiol Renal Physiol 2007 Feb; 292(2):F837-44.
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11. Bischof D, Elsawa SF, Mantchev G, Yoon J, Michels GE, Nilson A, Sutor SL, Platt JL, Ansell SM, von Bulow G, Bram RJ. Selective activation of TACI by syndecan-2. Blood 2006 Apr 15; 107(8):3235-42. Epub 2005 Dec 15.
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12. Diaz-de-Durana Y, Mantchev GT, Bram RJ, Franco A. TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo. Blood 2006 Jan 15; 107(2):594-601. Epub 2005 Sep 29.
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13. Nagano J, Kitamura K, Hujer KM, Ward CJ, Bram RJ, Hopfer U, Tomita K, Huang CF, Miller RT. Fibrocystin interacts with CAML, a protein involved in Ca2+ signaling. Biochemical & Biophysical Research Communications 2005 Dec 16; 338(2):880-9.
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14. Seyler TM, Park YW, Takemura S, Bram RJ, Kurtin PJ, Goronzy JJ, Weyand CM. BLyS and APRIL in rheumatoid arthritis. J Clin Invest 2005 Nov; 115(11):3083-92.
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15. Tran DD, Edgar CE, Heckman KL, Sutor SL, Huntoon CJ, van Deursen J, McKean DL, Bram RJ. CAML is a p56Lck-interacting protein that is required for thymocyte development. Immunity 2005 Aug; 23(2):139-52.
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16. Castigli E, Wilson SA, Scott S, Dedeoglu F, Xu SL, Lam KP, Bram RJ, Jabara H, Geha RS. TACI and BAFF-R mediate isotype switching in B cells. J Exp Med 2005 Jan 3; 201(1):35-9.
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17. Novak AJ, Grote DM, Stenson M, Ziesmer SC, Witzig TE, Habermann TM, Harder B, Ristow KM, Bram RJ, Jelinek DF, Gross JA, Ansell SM. Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome. Blood 2004 Oct 15; 104(8):2247-53.
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18. O'Connor BP, Raman VS, Erickson LD, Cook WJ, Weaver LK, Ahonen C, Lin LL, Mantchev GT, Bram RJ, Noelle RJ. BCMA is essential for the survival of long-lived bone marrow plasma cells. J Exp Med 2004 Jan 5; 199(1):91-7.
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19. Tran DD, Russell HR, Sutor SL, van Deursen J, Bram RJ. CAML is required for efficient EGF receptor recycling. Developmental Cell 2003 Aug; 5(2):245-56.
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20. Feng PH, Park J, Lee BS, Lee SH, Bram RJ, Jung JU. Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis. J Virol 2002 Nov; 76(22):11491-504.
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21. Novak AJ, Bram RJ, Kay NE, Jelinek DF. Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival. Blood 2002 Oct 15; 100(8):2973-9.
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22. von Bulow GU, van Deursen JM, Bram RJ. Regulation of the T-independent humoral response by TACI. Immunity 2001 May; 14(5):573-82.
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23. Tovey SC, Bootman MD, Lipp P, Berridge MJ, Bram RJ. Calcium-modulating cyclophilin ligand desensitizes hormone-evoked calcium release. Biochem Biophys Res Commun 2000 Sep 16; 276(1):97-100.
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24. von Bulow GU, Russell H, Copeland NG, Gilbert DJ, Jenkins NA, Bram RJ. Molecular cloning and functional characterization of murine transmembrane activator and CAML interactor (TACI) with chromosomal localization in human and mouse. Mamm Genome 2000 Aug; 11(8):628-32.
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25. Holloway MP, Bram RJ. Co-localization of Calcium-Modulating cyclophilin Ligand (CAML) with intracellular calcium pools. Journal of Biological Chemistry 1998; 273:16346-50.
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26. von Bulow GU, Bram RJ. NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily. Science 1997 Oct 3; 278(5335):138-41.
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27. Bram RJ. Isolation of a cDNA encoding the chicken homologue of the human calcium-modulating cyclophilin ligand. Gene 1996 Oct 3; 174(2):307-9.
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28. Holloway MP, Bram RJ. A hydrophobic domain of Ca2+-modulating cyclophilin ligand modulates calcium influx signaling in T lymphocytes. J Biol Chem 1996 Apr 12; 271(15):8549-52.
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29. Bram RJ, Valentine V, Shapiro DN, Jenkins NA, Gilbert DJ, Copeland NG. The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13. Genomics 1996 Jan 15; 31(2):257-60.
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30. Serafini AT, Lewis RS, Clipstone NA, Bram RJ, Fanger C, Fiering S, Herzenberg LA, Crabtree GR. Isolation of mutant T lymphocytes with defects in capacitative calcium entry. Immunity 1995 Aug; 3(2):239-50.
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31. Bram RJ, Crabtree GR. Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. Nature 1994 Sep 22; 371(6495):355-8.
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32. Bram RJ, Hung DT, Martin PK, Schreiber SL, Crabtree GR. Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Mol Cell Biol 1993 Aug; 13(8):4760-9.
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33. Flanagan WM, Corthesy B, Bram RJ, Crabtree GR. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature 1991 Aug 29; 352(6338):803-7.
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34. Eichler I, Joris L, Hsu YP, Van Wye J, Bram R, Moss R. Nonopsonic antibodies in cystic fibrosis. Pseudomonas aeruginosa lipopolysaccharide-specific immunoglobulin G antibodies from infected patient sera inhibit neutrophil oxidative responses. Journal of Clinical Investigation 1989; 84(6):1794-804.
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35. Bram RJ, Kornberg RD. Isolation of a Saccharomyces cerevisiae centromere DNA-binding protein, its human homolog, and its possible role as a transcription factor. Mol Cell Biol 1987 Jan; 7(1):403-9.
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36. Bram RJ, Lue NF, Kornberg RD. A GAL family of upstream activating sequences in yeast: roles in both induction and repression of transcription. EMBO J 1986 Mar; 5(3):603-8.
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37. Bram RJ, Kornberg RD. Specific protein binding to far upstream activating sequences in polymerase II promoters. Proc Natl Acad Sci U S A 1985 Jan; 82(1):43-7.
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38. Bram RJ, Young RA, Steitz JA. The ribonuclease III site flanking 23S sequences in the 30S ribosomal precursor RNA of E. coli. Cell 1980 Feb; 19(2):393-401.
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