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Publications - Kurt A . Jaeckle, M.D.

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  1. Jaeckle KA, Ballman K, Furth A, Buckner JC. Correlation of enzyme-inducing anticonvulsant use with outcome of patients with glioblastoma. Neurology 2009 Oct 13; 73(15):1207-13.
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  2. Galanis E, Jaeckle KA, Maurer MJ, Reid JM, Ames MM, Hardwick JS, Reilly JF, Loboda A, Nebozhyn M, Fantin VR, Richon VM, Scheithauer B, Giannini C, Flynn PJ, Moore DF Jr, Zwiebel J, Buckner JC. Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study. J Clin Oncol 2009 Apr 20; 27(12):2052-8. Epub 2009 Mar 23.
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  3. Santisteban M, Buckner JC, Reid JM, Wu W, Scheithauer BW, Ames MM, Felten SJ, Nikcevich DA, Wiesenfeld M, Jaeckle KA, Galanis E. Phase II trial of two different irinotecan schedules with pharmacokinetic analysis in patients with recurrent glioma: North Central Cancer Treatment Group results. J Neurooncol 2009 Apr; 92(10):165-75 Epub 2008 Dec 10.
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  4. Santisteban M, Buckner JC, Reid JM, Wu W, Scheithauer BW, Ames MM, Felten SJ, Nikcevich DA, Wiesenfeld M, Jaeckle KA, Galanis E, North Central Cancer Treatment Group. Phase II trial of two different irinotecan schedules with pharmacokinetic analysis in patients with recurrent glioma: North Central Cancer Treatment Group results. J Neurooncol 2009 Apr; 92(2):165-75. Epub 2008 Dec 10.
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  5. Brown PD, Krishnan S, Sarkaria JN, Wu W, Jaeckle KA, Uhm JH, Geoffroy FJ, Arusell R, Kitange G, Jenkins RB, Kugler JW, Morton RF, Rowland KM Jr, Mischel P, Yong WH, Scheithauer BW, Schiff D, Giannini C, Buckner JC, North Central Cancer Treatment Group Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177. J Clin Oncol 2008 Dec 1; 26(34):5603-9. Epub 2008 Oct 27.
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  6. Grothey A, Adjei AA, Alberts SR, Perez EA, Jaeckle KA, Loprinzi CL, Sargent DJ, Sloan JA, Buckner JC, North Central Cancer Treatment Group. North Central Cancer Treatment Group--achievements and perspectives. Semin Oncol 2008 Oct; 35(5):530-44.
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  7. Tun HW, Personett D, Baskerville KA, Menke DM, Jaeckle KA, Kreinest P, Edenfield B, Zubair AC, O'Neill BP, Lai WR, Park PJ, McKinney M. Pathway analysis of primary central nervous system lymphoma. Blood 2008 Mar 15; 111(6):3200-10. Epub 2008 Jan 09.
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  8. Blitshteyn S, Crook JE, Jaeckle KA. Is there an association between meningioma and hormone replacement therapy? J Clin Oncol 2008 Jan 10; 26(2):279-82.
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  9. Ballman KV, Buckner JC, Brown PD, Giannini C, Flynn PJ, LaPlant BR, Jaeckle KA. The relationship between six-month progression-free survival and 12-month overall survival end points for phase II trials in patients with glioblastoma multiforme. Neuro-oncol 2007 Jan; 9(1):29-38.
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  10. Brown PD, Jensen AW, Felten SJ, Ballman KV, Schaefer PL, Jaeckle KA, Cerhan JH, Buckner JC. Detrimental effects of tumor progression on cognitive function of patients with high-grade glioma. J Clin Oncol 2006 Dec 1; 24(34):5427-33.
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  11. Groves MD, Puduvalli VK, Conrad CA, Gilbert MR, Yung WK, Jaeckle K, Liu V, Hess KR, Aldape KD, Levin VA. Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: a relationship among efficacy, joint toxicity and anticonvulsant status. J Neurooncol 2006 Oct; 80(1):83-90. Epub 2006 Apr 25.
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  12. Krishnan S, Brown PD, Ballman KV, Fiveash J, Uhm JH, Giannini C, Jaeckle KA, Geoffroy FJ, Nabors LB, Buckner JC. Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: Results of north central cancer treatment group protocol N0177. Int J Radiat Oncol Biol Phys 2006 Jul 15; 65(4):1192-9.
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  13. Krishnan S, Brown PD, Ballman KV, Fiveash JB, Uhm JH, Giannini C, Jaeckle KA, Geoffroy FJ, Nabors LB, Buckner JC, North Central Cancer Treatment Group. Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: results of North Central Cancer Treatment Group protocol N0177. Int J Radiat Oncol Biol Phys 2006 Jul 15; 65(4):1192-9. Epub 2006 Apr 19.
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  14. Jaeckle KA. Neoplastic meningitis from systemic malignancies: diagnosis, prognosis and treatment. Semin Oncol 2006 Jun; 33(3):312-23.
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  15. Marshall NE, Ballman KV, Michalak JC, Schomberg PJ, Burton GV, Sandler HM, Cascino TL, Jaeckle KA, Buckner JC. Ototoxicity of cisplatin plus standard radiation therapy vs. accelerated radiation therapy in glioblastoma patients. J Neurooncol 2006 May; 77(3):315-20.
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  16. Deen HG, Miller DA, Kostick DA, Jaeckle KA. Removal of an orbital metallic foreign body to facilitate magnetic resonance imaging: technical case report. Neurosurgery 2006 May; 58(5):E999; discussion E999.
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  17. Blitshteyn S, Jaeckle KA. Nonconvulsive status epilepticus in metastatic CNS disease. Neurology 2006 Apr 25; 66(8):1261-3.
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  18. Jaeckle KA, Ballman KV, Rao RD, Jenkins RB, Buckner JC. Current strategies in treatment of oligodendroglioma: evolution of molecular signatures of response. J Clin Oncol 2006 Mar 10; 24(8):1246-52.
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  19. Galanis E, Buckner JC, Maurer MJ, Kreisberg JI, Ballman K, Boni J, Peralba JM, Jenkins RB, Dakhil SR, Morton RF, Jaeckle KA, Scheithauer BW, Dancey J, Hidalgo M, Walsh DJ. Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study. J Clin Oncol 2005 Aug 10; 23(23):5294-304.
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  20. Blaney SM, Balis FM, Berg S, Arndt CAS, Heideman R, Geyer JR, Packer R, Adamson PC, Jaeckle K, Klenke R, Aikin A, Murphy R, McCully C, Poplack DG. Intrathecal mafosfamide: A preclinical pharmacology and phase I trial. J Clin Oncol 2005 Mar 1; 23(7):1555-63.
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  21. Jaeckle KA. Neurological manifestations of neoplastic and radiation-induced plexopathies. Semin Neurol 2004 Dec; 24(4):385-93.
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  22. Chang SM, Prados MD, Yung WKA, Fine H, Junck L, Greenberg H, Robins HI, Mehta M, Fink KL, Jaeckle KA, Kuhn J, Hess K, Schold C. Phase II study of neoadjuvant 1, 3-bis (2-chloroethyl)-1-nitrosourea and temozolomide for newly diagnosed anaplastic glioma - A North American Brain Tumor Consortium Trial. Cancer 2004 Apr 15; 100(8):1712-6.
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  23. Prados MD, Yung WKA, Jaeckle KA, Robins HI, Mehta MP, Fine HA, Wen PY, Cloughesy TF, Chang SM, Nicholas MK, Schiff D, Greenberg HS, Junck L, Fink KL, Hess KR, Kuhn J. Phase 1 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: A North American Brain Tumor Consortium study. Neuro-oncol 2004 Jan; 6(1):44-54.
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  24. Prados MD, Yung WKA, Fine HA, Greenberg HS, Junck L, Chang SM, Nicholas MK, Robins HI, Mehta MP, Fink KL, Jaeckle KA, Kuhn J, Hess KR, Schold SC. Phase 2 study of BCNU and temozolomide for recurrent glioblastoma multiforme: North American Brain Tumor Consortium study. Neuro-oncol 2004 Jan; 6(1):33-7.
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  25. Jaeckle KA, Hess KR, Yung WKA, Greenberg H, Fine H, Schiff D, Pollack IF, Kuhn J, Fink K, Mehta M, Cloughesy T, Nicholas MK, Chang S, Prados M. Phase II evaluation of temozolomide and 13-cis-retinoic acid for the treatment of recurrent and progressive malignant glioma: A North American Brain Tumor Consortium study. J Clin Oncol 2003 Jun 15; 21(12):2305-11.
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  26. Sherman AM, Jaeckle K, Meyers CA. Pretreatment cognitive performance predicts survival in patients with leptomeningeal disease. Cancer 2002 Sep 15; 95(6):1311-6.
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  27. Jaeckle KA, Batchelor T, O'Day SJ, Phuphanich S, New P, Lesser G, Cohn A, Gilbert M, Aiken R, Heros D, Rogers L, Wong E, Fulton D, Gutheil JC, Baidas S, Kennedy JM, Mason W, Moots P, Russell C, Swinnen LJ, Howell SB. An open label trial of sustained-release cytarabine (DepoCyt (TM)) for the intrathecal treatment of solid tumor neoplastic meningitis. J Neurooncol 2002 May; 57(3):231-9.
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  28. Groves MD, Puduvalli VK, Hess KR, Jaeckle KA, Peterson P, Yung WK, Levin VA. Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme. J Clin Oncol 2002 Mar 1; 20(5):1383-8.
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  29. Kunschner LJ, Fine H, Hess K, Jaeckle K, Kyritsis AP, Yung WKA. CI-980 for the treatment of recurrent or progressive malignant gliomas: National Central Nervous System Consortium Phase I-II Evaluation of CI-980. Cancer Invest 2002; 20(7-8):948-54.
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  30. Jaeckle KA, Phuphanich S, Bent MJ, Aiken R, Batchelor T, Campbell T, Fulton D, Gilbert M, Heros D, Rogers L, O'Day SJ, Akerley W, Allen J, Baidas S, Gertler SZ, Greenberg HS, LaFollette S, Lesser G, Mason W, Recht L, Wong E, Chamberlain MC, Cohn A, Intrathecal treatment of neoplastic meningitis due to breast cancer with a slow-release formulation of cytarabine. Br J Cancer 2001 Jan; 84(2):157-63.
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  31. Levin VA, Uhm JH, Jaeckle KA, Choucair A, Flynn PJ, Yung WKA, Prados MD, Bruner JM, Chang SM, Kyritsis AP, Gleason MJ, Hess KR. Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme. Clin Cancer Res 2000 Oct; 6(10):3878-84.
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  32. Fine HA, Figg WD, Jaeckle K, Wen PY, Kyritsis AP, Loeffler JS, Levin VA, Black PM, Kaplan R, Pluda JM, Yung WK. Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas. J Clin Oncol 2000 Feb; 18(4):708-15.
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  33. Verschraegen CF, Jaeckle K, Giovanella B, Knight V, Gilbert BE. Alternative administration of camptothecin analogues. Ann N Y Acad Sci 2000; 922:237-46.
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  34. Glantz MJ, Jaeckle KA, Chamberlain MC, Phuphanich S, Recht L, Swinnen LJ, Maria B, LaFollette S, Schumann GB, Cole BF, Howell SB. A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors. Clin Cancer Res 1999 Nov; 5(11):3394-402.
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  35. Hess KR, Wong ET, Jaeckle KA, Kyritsis AP, Levin VA, Prados MD, Yung WK. Response and progression in recurrent malignant glioma. Neuro-oncol 1999 Oct; 1(4):282-8.
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  36. Glantz MJ, LaFollette S, Jaeckle KA, Shapiro W, Swinnen L, Rozental JR, Phuphanich S, Rogers LR, Gutheil JC, Batchelor T, Lyter D, Chamberlain M, Maria BL, Schiffer C, Bashir R, Thomas D, Cowens W, Howell SB. Randomized trial of a slow-release versus a standard formulation of cytarabine for the intrathecal treatment of lymphomatous meningitis. J Clin Oncol 1999 Oct; 17(10):3110-6.
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  37. Groves MD, Maor MH, Meyers C, Kyritsis AP, Jaeckle KA, Yung WK, Sawaya RE, Hess K, Bruner JM, Peterson P, Levin VA. A phase II trial of high-dose bromodeoxyuridine with accelerated fractionation radiotherapy followed by procarbazine, lomustine, and vincristine for glioblastoma multiforme. Int J Radiat Oncol Biol Phys 1999 Aug 1; 45(1):127-35.
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  38. Wong ET, Hess KR, Gleason MJ, Jaeckle KA, Kyritsis AP, Prados MD, Levin VA, Yung WK. Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials. J Clin Oncol 1999 Aug; 17(8):2572.
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  39. Sodeyama N, Ishida K, Jaeckle KA, Zhang L, Azuma A, Yamada M, Mizusawa H, Wada Y. Pattern of epitopic reactivity of the anti-Hu antibody on HuD with and without paraneoplastic syndrome. Journal of Neurology, Neurosurgery & Psychiatry 1999 Jan; 66(1):97-9.
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  40. Jaeckle KA, Eyre HJ, Townsend JJ, Schulman S, Knudson HM, Belanich M, Yarosh DB, Bearman SI, Giroux DJ, Schold SC. Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study. J Clin Oncol 1998 Oct; 16(10):3310-5.
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  41. Wong ET, Jackson EF, Hess KR, Schomer DF, Hazle JD, Kyritsis AP, Jaeckle KA, Yung WK, Levin VA, Leeds NE. Correlation between dynamic MRI and outcome in patients with malignant gliomas. Neurology 1998 Mar; 50(3):777-81.
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  42. Taylor SA, Giroux DJ, Jaeckle KA, Panella TJ, Dakhil SR, Schold SC. Phase II study of Didemnin B in central nervous system tumors: a Southwest Oncology Group study. Invest New Drugs 1998-99; 16(4):331-2.
  43. Taylor SA, Giroux DJ, Townsend JJ, Craig JB, Vance RB, Solanki DL, Brown TD, Jaeckle KA. Phase II trial of amonafide in central nervous system tumors: A Southwest Oncology Group Study. Investig New Drugs 1998; 16:331-2.
  44. Przepiorka D, Jaeckle KA, Birdwell RR, Fuller GN, Kumar AJ, Huh YO, McCutcheon I. Successful treatment of progressive multifocal leukoencephalopathy with low-dose interleukin-2. Bone Marrow Transplant 1997 Dec; 20(11):983-7.
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  45. Kudelka AP, Levy T, Verschraegen CF, Edwards CL, Piamsomboon S, Termrungruanglert W, Freedman RS, Kaplan AL, Kieback DG, Meyers CA, Jaeckle KA, Loyer E, Steger M, Mante R, Mavligit G, Killian A, Tang RA, Gutterman JU, Kavanagh JJ. A phase I study of TNP-470 administered to patients with advanced squamous cell cancer of the cervix. Clin Cancer Res 1997 Sep; 3(9):1501-5.
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  46. Eng DY, DeMonte F, Ginsberg L, Fuller GN, Jaeckle K. Craniospinal dissemination of central neurocytoma. Report of two cases. J Neurosurg 1997 Mar; 86(3):547-52.
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  47. Kaba SE, Kyritsis AP, Hess K, Yung WK, Mercier R, Dakhil S, Jaeckle KA, Levin VA. TPDC-FuHu chemotherapy for the treatment of recurrent metastatic brain tumors. J Clin Oncol 1997 Mar; 15(3):1063-70.
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  48. Kaba SE, DeMonte F, Bruner JM, Kyritsis AP, Jaeckle KA, Levin V, Yung WK. The treatment of recurrent unresectable and malignant meningiomas with interferon alpha-2B. Neurosurgery 1997 Feb; 40(2):271-5.
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  49. Vriesendorp HM, Quadri SM, Jaeckle KA, Freedman RS, Cromeens DM. Proposal for translational analysis and development of clinical radiolabeled immunoglobulin therapy. Radiotherapy & Oncology 1996 Nov; 41(2):151-61.
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  50. Kyritsis AP, Yung WK, Jaeckle KA, Bruner J, Gleason MJ, Ictech SE, Flowers A, Levin VA. Combination of 6-thioguanine, procarbazine, lomustine, and hydroxyurea for patients with recurrent malignant gliomas. Neurosurgery 1996 Nov; 39(5):921-6.
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  51. Jaeckle KA. Paraneoplastic nervous system syndromes. Curr Opin Oncol 1996 May; 8(3):204-8.
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  52. Belanich M, Pastor M, Randall T, Guerra D, Kibitel J, Alas L, Li B, Citron M, Wasserman P, White A, Eyre H, Jaeckle K, Schulman S, Rector D, Prados M, Coons S, Shapiro W, Yarosh D. Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine. Cancer Res 1996 Feb 15; 56(4):783-8.
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  53. Moll JW, Antoine JC, Brashear HR, Delattre J, Drlicek M, Dropcho EJ, Giometto B, Graus F, Greenlee J, Honnorat J, Jaeckle KA, et al. Guidelines on the detection of paraneoplastic anti-neuronal-specific antibodies: report from the Workshop to the Fourth Meeting of the International Society of Neuro-Immunology on paraneoplastic neurological disease, held October 22-23, 1994, in Rotterdam, The Netherlands. Neurology 1995 Oct; 45(10):1937-41.
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  54. Jaeckle KA. Autoimmune mechanisms in the pathogenesis of paraneoplastic nervous system disease. Clinical Neurology & Neurosurgery 1995 Feb; 97(1):82-8.
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  55. Greenlee JE, Burns JB, Rose JW, Jaeckle KA, Clawson S. Uptake of systemically administered human anticerebellar antibody by rat Purkinje cells following blood-brain barrier disruption. Acta Neuropathol (Berl) 1995; 89(4):341-5.
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  56. Jaeckle KA. Immunotherapy of malignant gliomas. Semin Oncol 1994 Apr; 21(2):249-59.
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  57. Harris CP, Sigman JD, Jaeckle KA. Intravascular malignant lymphomatosis: amelioration of neurological symptoms with plasmapheresis. Ann Neurol 1994 Mar; 35(3):357-9.
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  58. Sakai K, Ogasawara T, Hirose G, Jaeckle KA, Greenlee JE. Analysis of autoantibody binding to 52-kd paraneoplastic cerebellar degeneration-associated antigen expressed in recombinant proteins. Ann Neurol 1993 Apr; 33(4):373-80.
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  59. Jaeckle KA. Causes and management of headaches in cancer patients. Oncology (Huntington) 1993 Apr; 7(4):27-31; discussion 31-2, 34.
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  60. Goodwin JW, Crowley J, Eyre HJ, Stafford B, Jaeckle KA, Townsend JJ. A phase II evaluation of tamoxifen in unresectable or refractory meningiomas: a Southwest Oncology Group study. J Neurooncol 1993 Jan; 15(1):75-7.
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  61. Greenlee JE, Parks TN, Jaeckle KA. Type Iia (anti-Hu') antineuronal antibodies produce destruction of rat cerebellar granule neurons in vitro. Neurology 1993; 43:2049-54.
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  62. Greenlee JE, Brashear HR, Jaeckle KA, Geleris A, Jordan K. Pursuing an occult carcinoma in a patient with subacute cerebellar degeneration and anticerebellar antibodies. Need for vigorous follow-up. West J Med 1992 Feb; 156(2):199-202.
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  63. Blumenfeld AM, Recht LD, Chad DA, DeGirolami U, Griffin T, Jaeckle KA. Coexistence of Lambert-Eaton myasthenic syndrome and subacute cerebellar degeneration: differential effects of treatment. Neurology 1991 Oct; 41(10):1682-5.
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  64. Taylor SA, Crowley J, Pollock TW, Eyre HJ, Jaeckle C, Hynes HE, Stephens RL. Objective antitumor activity of acivicin in patients with recurrent CNS malignancies: a Southwest Oncology Group trial. J Clin Oncol 1991 Aug; 9(8):1476-9.
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  65. Taylor SA, Crowley J, Vogel FS, Townsend JJ, Eyre HJ, Jaeckle KA, Hynes HE, Guy JT. Phase II evaluation of fludarabine phosphate in patients with central nervous system tumors. A Southwest Oncology Group trial. Invest New Drugs 1991 May; 9(2):195-7.
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  66. Jaeckle KA. Neuroimaging for central nervous system tumors. Semin Oncol 1991 Apr; 18(2):150-7.
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  67. Luque FA, Furneaux HM, Ferziger R, Rosenblum MK, Wray SH, Schold SC Jr, Glantz MJ, Jaeckle KA, Biran H, Lesser M, et al. Anti-Ri: an antibody associated with paraneoplastic opsoclonus and breast cancer. Ann Neurol 1991 Mar; 29(3):241-51.
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  68. Lachance DH, O'Neill BP, Macdonald DR, Jaeckle KA, Witzig TE, Li CY, Posner JB. Primary leptomeningeal lymphoma: report of 9 cases, diagnosis with immunocytochemical analysis, and review of the literature. Neurology 1991 Jan; 41(1):95-100.
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  69. Jaeckle KA. Opinion on paraneoplastic syndromes. Primary Care & Cancer 1991; 11:53-4.
  70. Jaeckle KA. Nerve plexus metastases. Neurologic Complications of System Cancer Neurologic Clinics 1991; 9(4):857-66.
  71. Jaeckle KA, Digre KB, Jones CR, Bailey PL, McMahill PC. Central neurogenic hyperventilation: pharmacologic intervention with morphine sulfate and correlative analysis of respiratory, sleep, and ocular motor dysfunction. Neurology 1990 Nov; 40(11):1715-20.
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  72. Jaeckle KA, Mittelman A, Hill FH. Phase II trial of Serratia marcescens extract in recurrent malignant astrocytoma. J Clin Oncol 1990 Aug; 8(8):1408-18.
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  73. Brashear HR, Greenlee JE, Jaeckle KA, Rose JW. Anticerebellar antibodies in neurologically normal patients with ovarian neoplasms. Neurology 1989 Dec; 39(12):1605-9.
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  74. Jaeckle KA, Graus F, Houghton A, Cardon-Cardo C, Nielsen SL, Posner JB. Autoimmune response of patients with paraneoplastic cerebellar degeneration to a Purkinje cell cytoplasmic protein antigen. Ann Neurol 1985 Nov; 18(5):592-600.
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  75. Jaeckle KA. Assessment of tumor markers in cerebrospinal fluid. Clin Lab Med 1985 Jun; 5(2):303-15.
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  76. Jaeckle KA, Krol G, Posner JB. Evolution of computed tomographic abnormalities in leptomeningeal metastases. Ann Neurol 1985 Jan; 17(1):85-9.
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  77. Jaeckle KA, Young DF, Foley KM. The natural history of lumbosacral plexopathy in cancer. Neurology 1985 Jan; 35(1):8-15.
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  78. Sowers JJ, Jaeckle KA, Allen JH, Correa-Paz F. Computed tomography in the diagnosis of congenital cytomegalic inclusion disease. South Med J 1982 Nov; 75(11):1421-4.
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  79. Jaeckle KA. Cerebrospinal fluid cytomorphology in systemic lupus erythematosus with Anton's syndrome. Acta Cytol 1982 Jul-Aug; 26(4):532-6.
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  80. Jaeckle KA, Freemon FR. Pokeweed poisoning. South Med J 1981 May; 74(5):639-40.
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  81. Jaeckle KA, Allen JH. Subdural hygroma: diagnosis with computed tomography. J Comput Tomogr 1979 Sep; 3(3):201-6.
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