Publications - Frank A . Sinicrope, M.D.

Back to Research Profile

1. Sinicrope FA, Rego RL, Ansell SM, Knutson KL, Foster NR, Sargent DJ. Intraepithelial effector (CD3+)/regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma. Gastroenterology 2009 Oct; 137(4):1270-9. Epub 2009 Jul 03.
   View PubMed
2. Sinicrope FA, Sargent DJ. Clinical implications of microsatellite instability in sporadic colon cancers. Curr Opin Oncol 2009 Jul; 21(4):369-73.
   View PubMed
3. Huang S, Okumura K, Sinicrope FA. BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells. Clin Cancer Res 2009 Jan 1; 15(1):150-9.
   View PubMed
4. Okumura K, Huang S, Sinicrope FA. Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737. Clin Cancer Res 2008 Dec 15; 14(24):8132-42.
   View PubMed
5. Sinicrope FA, Rego RL, Okumura K, Foster NR, O'Connell MJ, Sargent DJ, Windschitl HE. Prognostic impact of bim, puma, and noxa expression in human colon carcinomas. Clin Cancer Res 2008 Sep 15; 14(18):5810-8.
   View PubMed
6. Sinicrope FA, Rego RL, Foster NR, Thibodeau SN, Alberts SR, Windschitl HE, Sargent DJ. Proapoptotic Bad and Bid protein expression predict survival in stages II and III colon cancers. Clin Cancer Res 2008 Jul 1; 14(13):4128-33.
   View PubMed
7. Huang S, Sinicrope FA. BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells. Cancer Res 2008 Apr 15; 68(8):2944-51.
   View PubMed
8. Gines A, Cassivi SD, Martenson JA Jr, Schleck C, Deschamps C, Sinicrope FA, Alberts SR, Murray JA, Zinsmeister AR, Vazquez-Sequeiros E, Nichols FC 3rd, Miller RC, Quevedo JF, Allen MS, Alexander JA, Zais T, Haddock MG, Romero Y. Impact of endoscopic ultrasonography and physician specialty on the management of patients with esophagus cancer. Dis Esophagus 2008; 21(3):241-50.
   View PubMed
9. Half E, Sun Y, Sinicrope FA. Anti-EGFR and ErbB-2 antibodies attenuate cyclooxygenase-2 expression and cooperatively inhibit survival of human colon cancer cells. Cancer Lett 2007 Jun 28; 251(2):237-46. Epub 2006 Dec 26.
   View PubMed
10. Sinicrope FA, Rego RL, Garrity-Park MM, Foster NR, Sargent DJ, Goldberg RM, Wiesenfeld M, Witzig TE, Thibodeau SN, Burgart LJ. Alterations in cell proliferation and apoptosis in colon cancers with microsatellite instability. Int J Cancer 2007 Mar 15; 120(6):1232-8.
    View PubMed
11. Sinicrope FA, Rego RL, Foster N, Sargent DJ, Windschitl HE, Burgart LJ, Witzig TE, Thibodeau SN. Microsatellite instability accounts for tumor site-related differences in clinicopathologic variables and prognosis in human colon cancers. Am J Gastroenterol 2006 Dec; 101(12):2818-25. Epub 2006 Oct 06.
    View PubMed
12. Sinicrope FA, Rego RL, Halling KC, Foster N, Sargent DJ, La Plant B, French AJ, Laurie JA, Goldberg RM, Thibodeau SN, Witzig TE. Prognostic impact of microsatellite instability and DNA ploidy in human colon carcinoma patients. Gastroenterology 2006 Sep; 131(3):729-37.
    View PubMed
13. Bernold DM, Sinicrope FA. Advances in chemotherapy for colorectal cancer. Clin Gastroenterol Hepatol 2006 Jul; 4(7):808-21. Epub 2006 Jun 22.
    View PubMed
14. Cohen G, Mustafi R, Chumsangsri A, Little N, Nathanson J, Cerda S, Jagadeeswaran S, Dougherty U, Joseph L, Hart J, Yerian L, Tretiakova M, Yuan W, Obara P, Khare S, Sinicrope FA, Fichera A, Boss GR, Carroll R, Bissonnette M. Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci. Cancer Res 2006 Jun 1; 66(11):5656-64.
    View PubMed
15. Sinicrope FA. Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer. Mol Carcinog 2006 Jun; 45(6):447-54.
    View PubMed
16. Sinicrope FA, Rego RL, Halling KC, Foster NR, Sargent DJ, La Plant B, French AJ, Allegra CJ, Laurie JA, Goldberg RM, Witzig TE, Thibodeau SN. Thymidylate synthase expression in colon carcinomas with microsatellite instability. Clin Cancer Res 2006 May 1; 12(9):2738-44.
    View PubMed
17. Yeung BH, Huang DC, Sinicrope FA. PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells. J Biol Chem 2006 Apr 28; 281(17):11923-32. Epub 2006 Jan 30.
    View PubMed
18. Sinicrope FA, Penington RC. Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2. Mol Cancer Ther 2005 Oct; 4(10):1475-83.
19. Alberts SR, Sinicrope FA, Grothey A. N0147: a randomized phase III trial of oxaliplatin plus 5-fluorouracil/leucovorin with or without cetuximab after curative resection of stage III colon cancer. Clin Colorectal Cancer 2005 Sep; 5(3):211-3.
    View PubMed
20. Gill S, Sinicrope FA. Colorectal cancer prevention: Is an ounce of prevention worth a pound of cure? Semin Oncol 2005 Feb; 32(1):24-34.
    View PubMed
21. Sinicrope FA, Penington RC, Xi MT. Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells. Clin Cancer Res 2004 Dec 15; 10(24):8284-92.
    View PubMed
22. Wargovich MJ, Chang P, Velasco M, Sinicrope F, Eisenbrodt E, Sellin J. Expression of cellular adhesion proteins and abnormal glycoproteins in human aberrant crypt foci. Appl Immunohistochem Mol Morphol 2004 Dec; 12(4):350-5.
23. Sinicrope FA, Half E, Morris JS, Lynch PM, Morrow JD, Levin B, Hawk ET, Cohen DS, Ayers GD, Stephens LC. Cell proliferation and apoptotic indices predict adenoma regression in a placebo-controlled trial of celecoxib in familial adenomatous polyposis patients. Cancer Epidemiol Biomarkers Prev 2004 Jun; 13(6):920-7.
    View PubMed
24. Half E, Broaddus R, Danenberg KD, Danenberg PV, Ayers GD, Sinicrope FA. HER-2 receptor expression, localization, and activation in colorectal cancer cell lines and human tumors. Int J Cancer 2004 Feb 10; 108(4):540-8.
    View PubMed
25. Sinicrope FA, Gill S. Role of cyclooxygenase-2 in colorectal cancer. Cancer Metastasis Reviews 2004 Jan-Jun; 23(1-2):63-75.
    View PubMed
26. Sun YJ, Tang XM, Half E, Kuo MT, Sinicrope FA. Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. Cancer Res 2002 Nov 1; 62(21):6323-8.
    View PubMed
27. Bismar MM, Sinicrope FA. Radiation enteritis. Curr Gastroenterol Rep 2002 Oct; 4(5):361-5.
    View PubMed
28. Tang XM, Sun YJ, Half E, Kuo MT, Sinicrope F. Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells. Cancer Res 2002 Sep 1; 62(17):4903-8.
    View PubMed
29. Sinicrope FA, Gwyn K. Chemoprevention of colorectal cancer. Am J Gastroenterol 2002; 97:13-21.
    View PubMed
30. Half E, Tang XM, Gwyn K, Sahin A, Wathen K, Sinicrope FA. Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. Cancer Res 2002; 62:1676-81.
    View PubMed
31. Tatabe S, Sinicrope FA, Kuo MT. Induction of multidrug resistance protein MRP1and MRP3 and y-glutamylcystein synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. Biochem Biophys Res Commun 2002; 290:1427-33.
    View PubMed
32. Sample D, Wargovich MJ, Fischer SM, Inamdar N, Schwartz P, Wang X, Do, K-A, Sinicrope FA. A dose-finding study of aspirin for chemoprevention utilizing rectal mucosal PGE2 levels as a biomarker. Cancer Epidemiol Biomarkers Prev 2002; 11:275-9.
    View PubMed
33. Sample D, Sinicrope PS, Wargovich MJ, Sinicrope FA. Post study aspirin intake and factors motivating participation in a colorectal cancer chemoprevention trial. Cancer Epidemiol Biomarkers Prev 2002; 11:281-5.
    View PubMed
34. Tatabe S, Unate H, Sinicrope FA, Sakatani T, Sugamura K, Makino M, Ito H, Savaraj N, Kaibara N, Kuo MT. Expression of heavy subunit of y-Glutamylcysteine synthetase (y-GCSh) in human colorectal carcinoma. Int J Cancer 2002; 97:21-7.
    View PubMed
35. Boland CR, Sinicrope FA, Brenner D, Carethers J. Colorectal cancer prevention and treatment. Gastroenterology 2000; 118:S115-S28.
    View PubMed
36. Toyota M, Shen L, Ohe-Toyota M, Hamilton SR, Sinicrope FA, Issa J-P. Aberrant methylation of the COX-2 CpG island in colorectal tumors. Cancer Res 2000; 60:4044-8.
    View PubMed
37. Sinicrope FA, Roddey GR, McDonnell TJ, Shen Y, Stephens LC. Increased apoptosis accompanies neoplastic development in the human colorectum. Clin Cancer Res 1996 Dec;2(12):1999-2006.
38. Sinicrope FA, Roddey GR, McDonnell TJ, Shen Y, Stephens LC. Increased apoptosis accompanies neoplastic development in the human colorectum. Clin Cancer Res 1999; 2:1999-2006.
39. Molina M, Anja-Buta M, Lemoine M, Xi L, Frazier M, Sinicrope FA. Increased cyclooxygenase-2 expression in pancreatic carcinomas and cell lines: Growth inhibition by nonsteroidal anti-inflammatory drugs. Cancer Res 1999; 59:4356-62.
    View PubMed
40. Frazier ML, Sinicrope FA, Amos CI, Cleary KR, Lynch PM, Luthra R. Loci for efficient detection of microsatellite instability in hereditary nonpolyposis colorectal cancer. Oncology Reports 1999; 6:497-505.
    View PubMed
41. Sinicrope FA, Lemoine M, Xi L, Lynch PM, Cleary KR, Shen Y, Frazier ML. Reduced expression of cyclooxygenase-2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers. Gastroenterology 1999; 117:350-8.
    View PubMed
42. Bold RJ, Hess KR, Pearson AS, Grau AM, Sinicrope FA, Jennings M, McConkey DJ, Bucana CD, Cleary KR, Chiao PJ, Abbruzzese JL, Evans DB. Prognostic factors in resectable pancreatic cancer: P53 and bcl-2. J Gastrointest Surg 1999; 3:263-77.
    View PubMed
43. Sinicrope FA, Hart J, Lemoine M, Michelassi F, Lee JJ, Stephens LC. Apoptotic and mitotic indices predict patient survival rates in lymph node-negative colon carcinomas. Clin Cancer Res 1999; 5:1793-804.
    View PubMed
44. Sinicrope FA, Roddey GR, LeMoine M, Frazier M, Stephens LC, Shen Y, Zhang W. Loss of p21WAF1/Cip1 protein expression accompanies neoplastic progression in the sporadic colorectal cancers but not HNPCCs. Clin Cancer Res 1998; 4:1251-61.
    View PubMed
45. Sinicrope FA, Evans DB, Leach S, Cleary KR, Rich TA, Fenoglio C, Lee JJ, Abbruzzese JL. Bcl-2 and p53 expression in resectable pancreatic adenocarcinomas: association with clinical outcome. Clin Cancer Res 1996; 2:2015-22.
    View PubMed
46. Sinicrope FA, Pazdur R, Levin B. Phase I evaluation of sulindac plus 5-fluorouracil and levamisole: potential adjuvant therapy of colon carcinoma. Clin Cancer Res 1996; 2:37-41.
    View PubMed
47. Roubein LD, Lynch PM, Glober G, Sinicrope FA. Interobserver variability in endoscopic ultrasonography: a prospective evaluation. Gastrointest Endosc 1996; 5:573-7.
48. Al-Sabbagh R, Sinicrope FA, Sellin J, Roubein L. Short-chain fatty acid enemas: treatment of radiation proctitis. Am J Gastroenterol 1996; 91:1814-16.
    View PubMed
49. Sinicrope FA, Sugarman S. Role of adjuvant therapy in surgically resected colorectal carcinoma. Gastroenterology 1995; 109:984-93.
    View PubMed
50. Weber D, Dimopoulos M, Sinicrope FA, Alexanian R. VAD-cyclosporin therapy for VAD-resistant multiple myeloma. Leuk Lymphoma 1995; 19:159-63.
    View PubMed
51. Sinicrope FA, Hart J, Michelassi FM, Lee JJ. Prognostic value of bcl-2 oncoprotein expression in stage II colon carcinoma. Clin Cancer Res 1995; 1:1103-10.
    View PubMed
52. Sinicrope FA, Ruan S, Cleary KR, Lee JJ, Levin B. Bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res 1995; 55:237-41.
    View PubMed
53. Sinicrope FA, Levin B. Gastric cancer. Curr Opin in Gastroenterol 1994; 10:610-17.
54. Sinicrope FA, Sugarman SM. Adjuvant therapy of colon carcinoma: current status and future directions. Cancer Bull 1994; 46:344-51.
55. Sinicrope FA, Hart J, Michelassi F, Safa AR, Lee JJ, Brasitus TA. Relationship of P-glycoprotein and carcinoembryonic antigen expression in human colon carcinoma to local invasion, DNA ploidy, and disease relapse. Cancer 1994; 74:2908-17.
    View PubMed
56. Sinicrope FA, Levin B. Gastric cancer. Curr Opin in Gastroenterol 1993; 9:930-7.
57. Kavin H, Sinicrope FA, Esker AH. Perforation of the colon at endoscopy: a review. Am J Gastroenterology 1992; 87:161-7.
58. Sinicrope FA, Dudeja PK, Bissonnette BM, Safa AR, Brasitus TA. Modulation of P- glycoprotein-mediated drug transport by alterations in lipid fluidity of rat liver canalicular membrane vesicles. J Biol Chem 1992; 267:24995-5002.
    View PubMed