Publications - Derek C . Radisky, Ph.D.

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1. McKian KP, Reynolds CA, Visscher DW, Nassar A, Radisky DC, Vierkant RA, Degnim AC, Boughey JC, Ghosh K, Anderson SS, Minot D, Caudill JL, Vachon CM, Frost MH, Pankratz VS, Hartmann LC. Novel Breast Tissue Feature Strongly Associated With Risk of Breast Cancer. J Clin Oncol 2009 Oct 05. [Epub ahead of print]
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2. Vierkant RA, Hartmann LC, Pankratz VS, Anderson SS, Radisky D, Frost MH, Vachon CM, Ghosh K, Distad TJ, Degnim AC, Reynolds CA. Lobular involution: localized phenomenon or field effect? Breast Cancer Res Treat 2009 Sep; 117(1):193-6.
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3. Vierkant RA, Hartmann LC, Pankratz VS, Anderson SS, Radisky D, Frost MH, Vachon CM, Ghosh K, Distad TJ, Degnim AC, Reynolds CA. Lobular involution: localized phenomenon or field effect? Breast Cancer Res Treat 2009 Sep; 117(1):193-6. Epub 2008 Jul 01.
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4. Radisky DC, Hartmann LC. Mammary involution and breast cancer risk: transgenic models and clinical studies. J Mammary Gland Biol Neoplasia 2009 Jun; 14(2):181-91. Epub 2009 Apr 30.
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5. Radisky DC, Hartmann LC. Mammary involution and breast cancer risk: transgenic models and clinical studies. Journal of Mammary Gland Biology & Neoplasia 2009 Jun; 14(2):181-91.
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6. Santisteban M, Reiman JM, Asiedu MK, Behrens MD, Nassar A, Kalli KR, Haluska P, Ingle JN, Hartmann LC, Manjili MH, Radisky DC, Ferrone S, Knutson KL. Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells. Cancer Res 2009 Apr 1; 69(7):2887-95. Epub 2009 Mar 10.
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7. Chen CS, Nelson CM, Khauv D, Bennett S, Radisky ES, Hirai Y, Bissell MJ, Radisky DC. Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis. J Biol Chem 2009 Mar 13; 284(11):6877-84. Epub 2009 Jan 07.
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8. Radisky DC, Stallings-Mann M, Hirai Y, Bissell MJ. Single proteins might have dual but related functions in intracellular and extracellular microenvironments. Nat Rev Mol Cell Biol 2009 Mar; 10(3):228-34. Epub 2009 Feb 04.
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9. Marlow LA, Reynolds LA, Cleland AS, Cooper SJ, Gumz ML, Kurakata S, Fujiwara K, Zhang Y, Sebo T, Grant C, McIver B, Wadsworth JT, Radisky DC, Smallridge RC, Copland JA. Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth. Cancer Res 2009 Feb 15; 69(4):1536-44. Epub 2009 Feb 10.
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10. Alcaraz J, Xu R, Mori H, Nelson CM, Mroue R, Spencer VA, Brownfield D, Radisky DC, Bustamante C, Bissell MJ. Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. EMBO J 2008 Nov 5; 27(21):2829-38. Epub 2008 Oct 09.
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11. Cao Y, Wang L, Nandy D, Zhang Y, Basu A, Radisky D, Mukhopadhyay D. Neuropilin-1 upholds dedifferentiation and propagation phenotypes of renal cell carcinoma cells by activating Akt and sonic hedgehog axes. Cancer Res 2008 Nov 1; 68(21):8667-72.
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12. Nelson CM, Khauv D, Bissell MJ, Radisky DC. Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells. J Cell Biochem 2008 Sep 1; 105(1):25-33 Epub 2008 May 27.
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13. Frederick LA, Matthews JA, Jamieson L, Justilien V, Thompson EA, Radisky DC, Fields AP. Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer. Oncogene 2008 Aug 14; 27(35):4841-53. Epub 2008 Apr 21.
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14. Vierkant RA, Hartmann LC, Pankraz VS, Anderson SS, Radisky D, Frost MH, Vachon CM, Ghosh K, Distad TJ, Degnim AC, Reynolds CA. Lobular involution: localized phenomenon or field effect? Breast Cancer Res Treat 2008 July 1. Epub ahead of print.
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15. Nelson CM, Khauv D, Bissell MJ, Radisky DC. Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells. J. Cell Biochem. 2008 May 27. [Epub ahead of print]
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16. Turley EA, Veiseh M, Radisky DC, Bissell MJ. Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression? Nat Clin Pract Oncol 2008 May; 5(5):280-90. Epub 2008 Mar 18.
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17. Radisky DC, Przybylo JA. Matrix metalloproteinase-induced fibrosis and malignancy in breast and lung. Proc Am Thorac Soc 2008 Apr 15; 5(3):316-22.
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18. Cao Y, Wnag L, Nandy D, Zhang Y, Basu A, Radisky D, Mukhopadhyay D. Neuropilin-1 upholds dedifferentiation and propagation phenotypes of renal cell carcinoma cells by activating Akt and Sonic Hedgehog axes. Cancer Res 2008; 68:8667-72.
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19. Radisky DC. Fibroblasts act as co-conspirators for chemotherapy resistance. Cancer Biology and Therapy 2008; 7:1348-49.
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20. Radisky DC, LaBarge MA. Epithelial-Mesenchymal Transition and the Stem Cell Phenotype. Cell Stem Cell 2008; 2:511-12.
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21. Turley EA, Veiseh M, Radisky DC, Bissell MJ. Mechanisms of Disease: epithelial-mesenchymal transition-does cellular plasticity fuel neoplastic progression? Nat. Clin. Pract. Oncol. 2008; 5:280-90.
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22. Orlichenko LS, Radisky DC. Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development. Clin Exp Metastasis 2008; 25(6):593-600. Epub 2008 Feb 20.
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23. Radisky ES, Radisky DC. Stromal induction of breast cancer: Inflammation and invasion. Rev Endocr Metab Disord 2007 Sep; 8(3):279-87.
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24. Radisky DC, Kenny PA, Bissell MJ. Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT? J Cell Biochem 2007 Jul 1; 101(4):830-9.
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25. Hirai Y, Nelson CM, Yamazaki K, Takebe K, Przybylo J, Madden B, Radisky DC. Non-classical export of epimorphin and its adhesion to alphav-integrin in regulation of epithelial morphogenesis. J Cell Sci 2007 Jun 15; 120(Pt 12):2032-43. Epub 2007 May 29.
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26. Radisky ES, Radisky DC. Stromal induction of breast cancer: Inflammation and invasion. Rev Endocr Metab Disord 2007 Apr 20; Epub ahead of print.
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27. Radisky DC, Bissell MJ. NF-kappaB links oestrogen receptor signalling and EMT. Nat Cell Biol 2007 Apr; 9(4):361-3.
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28. Radisky DC, Kenny PA, Bissell MJ. Fibrosis and cancer: Do myofibroblasts come also from epithelial cells via EMT? J Cell Biochem101 2007:830-39.
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29. Hirai Y, Bissell MJ, Radisky DC. Extracellular localization of epimorphin/syntaxin-2. Blood 2007; 110(8):3082.
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30. Przybylo JA, Radisky DC. Matrix metalloproteinase-induced epithelial-mesenchymal transition: tumor progression at Snail's pace. Int J Biochem Cell Biol 2007; 39(6):1082-8. Epub 2007 Mar 12.
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31. Stallings-Mann M, Radisky D. Matrix metalloproteinase-induced malignancy in mammary epithelial cells. Cells Tissues Organs 2007; 185(1-3):104-10.
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32. Liu H, Radisky DC, Nelson CM, Zhang H, Fata JE, Roth RA, Bissell MJ. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci U S A 2006 Mar 14; 103(11):4134-9. Epub 2006 Mar 07.
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33. Radisky DC, Bissell MJ. Matrix metalloproteinase-induced genomic instability. Curr Opin Genet Dev 2006 Feb; 16(1):45-50. Epub 2005 Dec 27.
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34. Radisky DC. Epithelial-mesenchymal transition. J Cell Sci 2005 Oct 1; 118(19):4325-6.
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35. Radisky DC, Levy DD, Littlepage LE, Liu H, Nelson CM, Fata JE, Leake D, Godden EL, Albertson DG, Nieto MA, Werb Z, Bissell MJ. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 2005 Jul 7; 436(7047):123-7.
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36. Radisky DC, Levy DD, Littlepage LE, Liu H, Nelson CM, Fata JE, Leake D, Godden EL, Albertson DG, Nieto MA, Werb Z, Bissell MJ. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 2005 Jul 7; 436(7047):123-7.
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37. Liu H, Radisky DC, Bissell MJ. Proliferation and polarity in breast cancer: untying the gordian knot. Cell Cycle 2005 May; 4(5):646-9.
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38. Bissell MJ, Kenny PA, Radisky DC. Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes. Cold Spring Harb Symp Quant Biol 2005; 70:1-14.
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39. Radisky DC, Levy DD, Littlepage LE, Fata JE, Liu H, Nieto MA, Werb Z, Bissell MJ. MMP-3 induced Rac 1b causes genomic instability and epithelial-to-mesenchymal transition. Nature 2005; 436:123-27.
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40. Liu H, Radisky DC, Wang F, Bissell MJ. Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. J Cell Biol 2004 Feb 16; 164(4):603-12.
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41. Radisky DC, Bissell MJ. Cancer. Respect thy neighbor!. Science 2004 Feb 6; 303(5659):775-7.
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42. Novaro V, Radisky DC, Ramos Castro NE, Weisz A, Bissell MJ. Malignant mammary cells acquire independence from extracellular context for regulation of estrogen receptor alpha. Clin Cancer Res 2004 Jan 1; 10(1 Pt 2):402S-9S.
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43. Takebe K, Oka Y, Radisky D, Tsuda H, Tochigui K, Koshida S, Kogo K, Hirai Y. Epimorphin acts to induce hair follicle anagen in C57BL/6 mice. FASEB J 2003 Nov; 17(14):2037-47.
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44. Radisky DC, Hirai Y, Bissell MJ. Delivering the message: epimorphin and mammary epithelial morphogenesis. Trends Cell Biol 2003 Aug; 13(8):426-34.
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45. Tuttle MS, Radisky D, Li L, Kaplan J. A dominant allele of PDR1 alters transition metal resistance in yeast. J Biol Chem 2003 Jan 10; 278(2):1273-80.
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46. Bhattacharyya C, Grate LR, Rizki A, Radisky D, Molina FJ, Jordan MI, Bissell MJ, Mian IS. Simultaneous classification and relevant feature identification in high-dimensional spaces: application to molecular profiling data. Signal Processing 2003; 83:729-43.
47. Novaro V, Pustovrh C, Colman-Lerner A, Radisky D, Lo Nostro F, Paz D, Jawerbaum A, Gonzalez E. Nitric oxide induces gelatinase A (matrix metalloproteinase 2) during rat embryo implantation. Fertil Steril 2002 Dec; 78(6):1278-87.
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48. Bissell MJ, Radisky DC, Rizki A, Weaver VM, Petersen OW. The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation 2002 Dec; 70(9-10):537-46.
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49. Wang F, Hansen RK, Radisky D, Yoneda T, Barcellos-Hoff MH, Petersen OW, Turley EA, Bissell MJ. Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts. J Natl Cancer Inst 2002 Oct 2; 94(19):1494-503.
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50. Radisky D, Muschler J, Bissell MJ. Order and disorder: the role of extracellular matrix in epithelial cancer. Cancer Invest 2002; 20(1):139-53.
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51. Novaro V, Radisky D. 93rd Annual Meeting of the American Association for Cancer Research, San Francisco, CA, USA, 6-10 April 2002. Breast Cancer Res 2002; 4(4):165-8.
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52. Bissell MJ, Radisky D. Putting tumours in context. Nat Rev Cancer 2001 Oct; 1(1):46-54.
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53. McVey Ward D, Radisky D, Scullion MA, Tuttle MS, Vaughn M, Kaplan J. hVPS41 is expressed in multiple isoforms and can associate with vesicles through a RING-H2 finger motif. Exp Cell Res 2001 Jul 1; 267(1):126-34.
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54. Hirai Y, Radisky D, Boudreau R, Simian M, Stevens ME, Oka Y, Takebe K, Niwa S, Bissell MJ. Epimorphin mediates mammary luminal morphogenesis through control of C/EBPbeta. J Cell Biol 2001 May 14; 153(4):785-94.
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55. Radisky D, Hagios C, Bissell MJ. Tumors are unique organs defined by abnormal signaling and context. Semin Cancer Biol 2001 Apr; 11(2):87-95.
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56. Pujuguet P, Radisky D, Levy D, Lacza C, Bissell MJ. Trichostatin A inhibits beta-casein expression in mammary epithelial cells. J Cell Biochem 2001; 83(4):660-70.
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57. Pujuguet P, Radisky D, Levy D, Lacza C, Bissell MJ. Trichostatin A inhibits beta-casein expression in mammary epithelial cells. J Cell Biochem 2001; 83(4):660-70.
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58. Moler EJ, Radisky DC, Mian IS. Integrating naive Bayes models and external knowledge to examine copper and iron homeostasis in S. cerevisiae. Physiol Genomics 2000 Dec 18; 4(2):127-35.
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59. Radisky D, Kaplan J. Regulation of transition metal transport across the yeast plasma membrane. J Biol Chem 1999 Feb 19; 274(8):4481-4.
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60. Radisky DC, Babcock MC, Kaplan J. The yeast frataxin homologue mediates mitochondrial iron efflux. Evidence for a mitochondrial iron cycle. J Biol Chem 1999 Feb 19; 274(8):4497-9.
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61. Radisky DC, Kaplan J. Iron in cytosolic ferritin can be recycled through lysosomal degradation in human fibroblasts. Biochem J 1998 Nov 15; 336(Pt 1):201-5.
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62. Davis-Kaplan SR, Askwith CC, Bengtzen AC, Radisky D, Kaplan J. Chloride is an allosteric effector of copper assembly for the yeast multicopper oxidase Fet3p: an unexpected role for intracellular chloride channels. Proc Natl Acad Sci U S A 1998 Nov 10; 95(23):13641-5.
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63. Radisky DC, Snyder WB, Emr SD, Kaplan J. Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast. Proc Natl Acad Sci U S A 1997 May 27; 94(11):5662-6.
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64. Barrows LR, Radisky DC, Copp BR, Swaffar DS, Kramer RA, Warters RL, Ireland CM. Makaluvamines, marine natural products, are active anti-cancer agents and DNA topo II inhibitors. Anticancer Drug Des 1993 Oct; 8(5):333-47.
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65. Radisky DC, Radisky ES, Barrows LR, Copp BR, Kramer RA, Ireland CM. Novel cytotoxic topoisomerase II inhibiting pyrroloiminoquinones from Fijian sponges of the genus Zyzzya. J Am Chem Soc 1993; 115:1632-8.