Publications - Barry A. Borlaug, M.D.

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  1. Borlaug BA. Heart failure with preserved and reduced ejection fraction: different risk profiles for different diseases. Eur Heart J. 2013 May; 34(19):1393-5. Epub 2013 Mar 28.
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  2. Borlaug BA. Heart failure: Aldosterone antagonism for HFpEF. Nat Rev Cardiol. 2013 May; 10(5):244-6. Epub 2013 Apr 02.
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  3. Redfield MM, Chen HH, Borlaug BA, Semigran MJ, Lee KL, Lewis G, LeWinter MM, Rouleau JL, Bull DA, Mann DL, Deswal A, Stevenson LW, Givertz MM, Ofili EO, O'Connor CM, Felker GM, Goldsmith SR, Bart BA, McNulty SE, Ibarra JC, Lin G, Oh JK, Patel MR, Kim RJ, Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial. JAMA. 2013 Mar 27; 309(12):1268-77.
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  4. Lam CS, Shah AM, Borlaug BA, Cheng S, Verma A, Izzo J, Oparil S, Aurigemma GP, Thomas JD, Pitt B, Zile MR, Solomon SD. Effect of antihypertensive therapy on ventricular-arterial mechanics, coupling, and efficiency. Eur Heart J. 2013 Mar; 34(9):676-83. Epub 2012 Sep 10.
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  5. Abudiab MM, Redfield MM, Melenovsky V, Olson TP, Kass DA, Johnson BD, Borlaug BA. Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction. Eur J Heart Fail. 2013 Feb 20. [Epub ahead of print]
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  6. Coutinho T, Borlaug BA, Pellikka PA, Turner ST, Kullo IJ. Sex differences in arterial stiffness and ventricular-arterial interactions. J Am Coll Cardiol. 2013 Jan 8; 61(1):96-103. Epub 2012 Nov 01.
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  7. Fujimoto N, Borlaug BA, Lewis GD, Hastings JL, Shafer KM, Bhella PS, Carrick-Ranson G, Levine BD. Hemodynamic responses to rapid saline loading: the impact of age, sex, and heart failure. Circulation. 2013 Jan 1; 127(1):55-62. Epub 2012 Nov 21.
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  8. Andersen MJ, Ersbll M, Axelsson A, Gustafsson F, Hassager C, Kober L, Borlaug BA, Boesgaard S, Skovgaard LT, Moller JE. Sildenafil and diastolic dysfunction after acute myocardial infarction in patients with preserved ejection fraction: The sildenafil and diastolic dysfunction after acute myocardial infarction (SIDAMI) trial. Circulation. 2013; 127(11):1200-8.
  9. Borlaug BA. Aldosterone antagonism for HFpEF. Nat Rev Cardiol. 2013; 10(5):244-6.
  10. Mohammed SF, Borlaug BA, Roger VL, Mirzoyev SA, Rodeheffer RJ, Chirinos JA, Redfield MM. Comorbidity and ventricular and vascular structure and function in heart failure with preserved ejection fraction: a community-based study. Circ Heart Fail. 2012 Nov; 5(6):710-9. Epub 2012 Oct 17.
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  11. Bishu K, Deswal A, Chen HH, LeWinter MM, Lewis GD, Semigran MJ, Borlaug BA, McNulty S, Hernandez AF, Braunwald E, Redfield MM. Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction. Am Heart J. 2012 Nov; 164(5):763-770.e3. Epub 2012 Oct 16.
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  12. Redfield MM, Borlaug BA, Lewis GD, Mohammed SF, Semigran MJ, Lewinter MM, Deswal A, Hernandez AF, Lee KL, Braunwald E, Heart Failure Clinical Research Network. PhosphdiesteRasE-5 Inhibition to Improve CLinical Status and EXercise Capacity in Diastolic Heart Failure (RELAX) trial: rationale and design. Circ Heart Fail. 2012 Sep 1; 5(5):653-9.
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  13. Fang JC, DeMarco T, Givertz MM, Borlaug BA, Lewis GD, Rame JE, Gomberg-Maitland M, Murali S, Frantz RP, McGlothlin D, Horn EM, Benza RL. World Health Organization Pulmonary Hypertension group 2: pulmonary hypertension due to left heart disease in the adult--a summary statement from the Pulmonary Hypertension Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2012 Sep; 31(9):913-33.
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  14. Munger TM, Dong YX, Masaki M, Oh JK, Mankad SV, Borlaug BA, Asirvatham SJ, Shen WK, Lee HC, Bielinski SJ, Hodge DO, Herges RM, Buescher TL, Wu JH, Ma C, Zhang Y, Chen PS, Packer DL, Cha YM. Electrophysiological and hemodynamic characteristics associated with obesity in patients with atrial fibrillation. J Am Coll Cardiol. 2012 Aug 28; 60(9):851-60. Epub 2012 Jun 20.
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  15. Guazzi M, Borlaug BA. Pulmonary hypertension due to left heart disease. Circulation. 2012 Aug 21; 126(8):975-90.
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  16. Andersen MJ, Ersboll M, Bro-Jeppesen J, Gustafsson F, Hassager C, Kober L, Borlaug BA, Boesgaard S, Kjaergaard J, Moller JE. Exercise hemodynamics in patients with and without diastolic dysfunction and preserved ejection fraction after myocardial infarction. Circ Heart Fail. 2012 Jul 1; 5(4):444-51. Epub 2012 Jun 15.
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  17. Schwartzenberg S, Redfield MM, From AM, Sorajja P, Nishimura RA, Borlaug BA. Effects of vasodilation in heart failure with preserved or reduced ejection fraction implications of distinct pathophysiologies on response to therapy. J Am Coll Cardiol. 2012 Jan 31; 59(5):442-51.
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  18. Tedford RJ, Hassoun PM, Mathai SC, Girgis RE, Russell SD, Thiemann DR, Cingolani OH, Mudd JO, Borlaug BA, Redfield MM, Lederer DJ, Kass DA. Pulmonary capillary wedge pressure augments right ventricular pulsatile loading. Circulation. 2012 Jan 17; 125(2):289-97. Epub 2011 Nov 30.
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  19. Gharacholou SM, Scott CG, Borlaug BA, Kane GC, McCully RB, Oh JK, Pellikka PA. Relationship between diastolic function and heart rate recovery after symptom-limited exercise. J Card Fail. 2012 Jan; 18(1):34-40. Epub 2011 Nov 09.
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  20. From AM, Lam CS, Pitta SR, Kumar PV, Balbissi KA, Booker JD, Singh IM, Sorajja P, Reeder GS, Borlaug BA. Bedside assessment of cardiac hemodynamics: the impact of noninvasive testing and examiner experience. Am J Med. 2011 Nov; 124(11):1051-7. Epub 2011 Sep 22.
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  21. Scantlebury DC, Borlaug BA. Why are women more likely than men to develop heart failure with preserved ejection fraction? Curr Opin Cardiol. 2011 Nov; 26(6):562-8.
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  22. From AM, Borlaug BA. Heart failure with preserved ejection fraction: pathophysiology and emerging therapies. Cardiovasc Ther. 2011 Aug; 29(4):e6-21. Epub 2010 Mar 29.
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  23. Borlaug BA, Kass DA. Ventricular-vascular interaction in heart failure. Cardiol Clin. 2011 Aug; 29(3):447-59.
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  24. Borlaug BA, Jaber WA, Ommen SR, Lam CS, Redfield MM, Nishimura RA. Diastolic relaxation and compliance reserve during dynamic exercise in heart failure with preserved ejection fraction. Heart. 2011 Jun; 97(12):964-9. Epub 2011 Apr 08.
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  25. Borlaug BA, Redfield MM. Diastolic and systolic heart failure are distinct phenotypes within the heart failure spectrum. Circulation. 2011 May 10; 123(18):2006-13; discussion 2014.
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  26. Borlaug BA, Kass DA. Invasive hemodynamic assessment in heart failure. Cardiol Clin. 2011 May; 29(2):269-80.
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  27. Borlaug BA, Paulus WJ. Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment. Eur Heart J. 2011 Mar; 32(6):670-9. Epub 2010 Dec 07.
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  28. Gharacholou SM, Maleszewski JJ, Borlaug BA, Cosio FG, Dearani JA, Kushwaha SS, Ammash NM. "Carcinoid-like" tricuspid valvulopathy associated with nephrogenic systemic fibrosis. Echocardiography. 2011 Mar; 28(3):E46-9. Epub 2011 Mar 03.
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  29. Park SJ, Nishimura RA, Borlaug BA, Sorajja P, Oh JK. The effect of loading alterations on left ventricular torsion: a simultaneous catheterization and two-dimensional speckle tracking echocardiographic study. Eur J Echocardiogr. 2010 Oct; 11(9):770-7. Epub 2010 May 18.
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  30. Borlaug BA, Olson TP, Lam CS, Flood KS, Lerman A, Johnson BD, Redfield MM. Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction. J Am Coll Cardiol. 2010 Sep 7; 56(11):845-54.
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  31. Borlaug BA, Nishimura RA, Sorajja P, Lam CS, Redfield MM. Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction. Circ Heart Fail. 2010 Sep; 3(5):588-95. Epub 2010 Jun 11.
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  32. Borlaug BA, Redfield MM. Heart Failure with Reduced the Preserved Ejection Fraction Represent Distinct Phenotypes in the Heart Failure Syndrome. Circulation. 2010 Jun 14 (in press).
  33. Lam CS, Grewal J, Borlaug BA, Ommen SR, Kane GC, McCully RB, Pellikka PA. Size, shape, and stamina: the impact of left ventricular geometry on exercise capacity. Hypertension. 2010 May; 55(5):1143-9. Epub 2010 Mar 09.
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  34. Boilson BA, Schirger JA, Borlaug BA. Caveat medicus! Pulmonary hypertension in the elderly: a word of caution. Eur J Heart Fail. 2010 Jan; 12(1):89-93.
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  35. Sobieszczyk P, Borlaug BA, Gornik HL, Knauft WD, Beckman JA. Glycyrrhetinic acid attenuates vascular smooth muscle vasodilatory function in healthy humans. Clin Sci (Lond) 2010; 119(10):437-42. Epub 2010 Aug 05.
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  36. Borlaug BA. Sex, load and relaxation: Are women more susceptible to afterload-dependent diastolic dysfunciton? J Am Coll Cardiol. 2010 (n press).
  37. Madhavan M, Borlaug BA, Lerman A, Rihal CS, Prasad A. Stress hormone and circulating biomarker profile of apical ballooning syndrome (Takotsubo cardiomyopathy): insights into the clinical significance of B-type natriuretic peptide and troponin levels. Heart. 2009 Sep; 95(17):1436-41. Epub 2009 May 24.
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  38. Jaber WA, Sorajja P, Borlaug BA, Nishimura RA. Differentiation of tricuspid regurgitation from constrictive pericarditis: novel criteria for diagnosis in the cardiac catheterisation laboratory. Heart. 2009 Sep; 95(17):1449-54. Epub 2009 May 17.
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  39. Borlaug BA, Lam CS, Roger VL, Rodeheffer RJ, Redfield MM. Contractility and ventricular systolic stiffening in hypertensive heart disease insights into the pathogenesis of heart failure with preserved ejection fraction. J Am Coll Cardiol. 2009 Jul 28; 54(5):410-8.
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  40. Lam CS, Borlaug BA, Kane GC, Enders FT, Rodeheffer RJ, Redfield MM. Age-associated increases in pulmonary artery systolic pressure in the general population. Circulation. 2009 May 26; 119(20):2663-70. Epub 2009 May 11.
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  41. Borlaug BA, Kass DA. Invasive hemodynamic assessment in heart failure. Heart Fail Clin. 2009 Apr; 5(2):217-28.
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  42. Lam CS, Roger VL, Rodeheffer RJ, Borlaug BA, Enders FT, Redfield MM. Pulmonary hypertension in heart failure with preserved ejection fraction: a community-based study. J Am Coll Cardiol. 2009 Mar 31; 53(13):1119-26.
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  43. Borlaug BA. Treatment of heart failure with preserved ejection fraction. Curr Treat Options Cardiovasc Med. 2009 Feb; 11(1):79-87.
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  44. Sorajja P, Borlaug BA. Severe heart failure in the setting of relatively mild mitral stenosis: the role of invasive hemodynamic assessment. Catheter Cardiovasc Interv. 2008 Nov 1; 72(5):739-48.
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  45. Borlaug BA, Kass DA. Ventricular-vascular interaction in heart failure. Heart Fail Clin. 2008 Jan; 4(1):23-36.
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  46. Mudd JO, Borlaug BA, Johnston PV, Kral BG, Rouf R, Blumenthal RS, Kwiterovich PO Jr. Beyond low-density lipoprotein cholesterol: defining the role of low-density lipoprotein heterogeneity in coronary artery disease. J Am Coll Cardiol. 2007 Oct 30; 50(18):1735-41 Epub 2007 Oct 15.
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  47. Borlaug BA, Melenovsky V, Redfield MM, Kessler K, Chang HJ, Abraham TP, Kass DA. Impact of arterial load and loading sequence on left ventricular tissue velocities in humans. J Am Coll Cardiol. 2007 Oct 16; 50(16):1570-7 Epub 2007 Oct 1.
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  48. Melenovsky V, Borlaug BA, Fetics B, Kessler K, Shively L, Kass DA. Estimation of central pressure augmentation using automated radial artery tonometry.[see comment]. J Hypertens. 2007 Jul; 25(7):1403-9.
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  49. Lam CS, Roger VL, Rodeheffer RJ, Bursi F, Borlaug BA, Ommen SR, Kass DA, Redfield MM. Cardiac structure and ventricular-vascular function in persons with heart failure and preserved ejection fraction from Olmsted County, Minnesota. Circulation. 2007 Apr 17; 115(15):1982-90. Epub 2007 Apr 02.
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  50. Melenovsky V, Borlaug BA, Rosen B, Hay I, Ferruci L, Morell CH, Lakatta EG, Najjar SS, Kass DA. Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: the role of atrial remodeling/dysfunction. J Am Coll Cardiol. 2007 Jan 16; 49(2):198-207.
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  51. Borlaug BA, Melenovsky V, Russell SD, Kessler K, Pacak K, Becker LC, Kass DA. Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. Circulation. 2006 Nov 14; 114(20):2138-47. Epub 2006 Nov 06.
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  52. Forfia PR, Fisher MR, Mathai SC, Housten-Harris T, Hemnes AR, Borlaug BA, Chamera E, Corretti MC, Champion HC, Abraham TP, Girgis RE, Hassoun PM. Tricuspid annular displacement predicts survival in pulmonary hypertension. Am J Respir Crit Care Med. 2006 Nov 1; 174(9):1034-41. Epub 2006 Aug 03.
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  53. Borlaug BA, Kass DA. Mechanisms of diastolic dysfunction in heart failure. Trends Cardiovasc Med. 2006 Nov; 16(8):273-9.
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  54. Borlaug BA, Melenovsky V, Marhin T, Fitzgerald P, Kass DA. Sildenafil inhibits beta-adrenergic-stimulated cardiac contractility in humans. Circulation. 2005 Oct 25; 112(17):2642-9.
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  55. Redfield MM, Jacobsen SJ, Borlaug BA, Rodeheffer RJ, Kass DA. Age- and gender-related ventricular-vascular stiffening: a community-based study. Circulation. 2005 Oct 11; 112(15):2254-62. Epub 2005 Oct 03.
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  56. Melenovsky V, Hay I, Fetics BJ, Borlaug BA, Kramer A, Pastore JM, Berger R, Kass DA. Functional impact of rate irregularity in patients with heart failure and atrial fibrillation receiving cardiac resynchronization therapy. Eur Heart J. 2005 Apr; 26(7):705-11.
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