Publications - Michelle M. Mielke, Ph.D.

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  1. Petersen RC, Aisen P, Boeve BF, Geda YE, Ivnik RJ, Knopman DS, Mielke M, Pankratz VS, Roberts R, Rocca WA, Weigand S, Weiner M, Wiste H, Jack CR Jr. Criteria for mild cognitive impairment due to alzheimer's disease in the community. Ann Neurol. 2013 May 20. [Epub ahead of print]
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  2. Roberts RO, Knopman DS, Geda YE, Cha RH, Pankratz VS, Baertlein L, Boeve BF, Tangalos EG, Ivnik RJ, Mielke MM, Petersen RC. Association of diabetes with amnestic and nonamnestic mild cognitive impairment. Alzheimers Dement. 2013 Apr 03. [Epub ahead of print]
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  3. Jack CR Jr, Wiste HJ, Lesnick TG, Weigand SD, Knopman DS, Vemuri P, Pankratz VS, Senjem ML, Gunter JL, Mielke MM, Lowe VJ, Boeve BF, Petersen RC. Brain beta-amyloid load approaches a plateau. Neurology. 2013 Mar 5; 80(10):890-6. Epub 2013 Feb 27.
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  4. Roberts RO, Geda YE, Knopman DS, Cha RH, Pankratz VS, Boeve BF, Tangalos EG, Ivnik RJ, Mielke MM, Petersen RC. Cardiac disease associated with increased risk of nonamnestic cognitive impairment: stronger effect on women. JAMA Neurol. 2013 Mar 1; 70(3):374-82.
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  5. Parker DC, Mielke MM, Yu Q, Rosenberg PB, Jain A, Lyketsos CG, Fedarko NS, Oh ES. Plasma neopterin level as a marker of peripheral immune activation in amnestic mild cognitive impairment and Alzheimer's disease. Int J Geriatr Psychiatry PMCID PMC3505262. 2013 Feb; 28(2):149-54.
  6. Geda YE, Ragossnig M, Roberts LA, Roberts RO, Pankratz VS, Christianson TJ, Mielke MM, Levine JA, Boeve BF, Sochor O, Tangalos EG, Knopman DS, Petersen RC. Caloric intake, aging, and mild cognitive impairment: a population-based study. J Alzheimers Dis. 2013 Jan 1; 34(2):501-7.
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  7. Nowrangi MA, Lyketsos CG, Leoutsakos J-MS, Oishi K, Albert M, Mori S, Mielke MM. Longitudinal, region-specific course of diffusion tensor imaging measures in mild cognitive impairment and Alzheimer’s dementia. Alzheimer’s Dement. 2013 (in press).
  8. Miller VM, Garovic VD, Kantarci K, Barnes JN, Jayachandran J, Mielke MM, Joyner MJ, Shuster LT, Rocca WA. Sex-specific risk of cardiovascular disease and cognitive decline Biol Sex Differences. 2013.
  9. Leyhe T, Darreh-Shori T, Laske C, Mielke MM, Maetzler W. Biomarkers in Alzheimer's disease and lewy body disorders with dementia. Int J Alzheimers Dis. 2013; 2013:473181. Epub 2013 Jan 09.
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  10. Trushina, E, Dutta, T, Persson X-MT, Mielke MM, Petersen RC. Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer’s disease using metabolomics approach. PLoS One. 2013 (in press).
  11. Roberts RO, Knopman DS, Geda YE, Cha RH, Pankratz VS, Baertlein L, Boeve BF, Tangalos EG, Ivnik RJ, Mielke MM, Petersen RC. Association of diabetes with amnestic and non-amnestic mild cognitive impairment. Alzheimer's Dement. 2013 (in press).
  12. Rabins PV, Schwartz S, Black BS, Corcoran C, Fauth E, Mielke M, Christensen J, Lyketsos C, Tschanz J. Predictors of progression to severe Alzheimer Disease in an incidence sample. Alzheimer’s Dement. 2013; 9(2):204-7.
  13. Mielke MM, Roberts RO, Savica R, Cha R, Drubach DI, Christianson T, Pankratz VS, Geda YE, Machulda MM, Ivnik RJ, Knopman DS, Boeve BF, Rocca WA, Petersen RC. Assessing the Temporal Relationship Between Cognition and Gait: Slow Gait Predicts Cognitive Decline in the Mayo Clinic Study of Aging. J Gerontol A Biol Sci Med Sci. 2012 Dec 18. [Epub ahead of print]
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  14. Rosenberg PB, Mielke MM, Han D, Leoutsakos JS, Lyketsos CG, Rabins PV, Zandi PP, Breitner JC, Norton MC, Welsh-Bohmer KA, Zuckerman IH, Rattinger GB, Green RC, Corcoran C, Tschanz JT. The association of psychotropic medication use with the cognitive, functional, and neuropsychiatric trajectory of Alzheimer's disease. Int J Geriatr Psychiatry. 2012 Dec; 27(12):1248-57. Epub 2012 Feb 29.
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  15. Knopman DS, Jack CR Jr, Wiste HJ, Weigand SD, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Roberts RO, Boeve BF, Petersen RC. Brain injury biomarkers are not dependent on beta-amyloid in normal elderly. Ann Neurol. 2012 Nov 23. [Epub ahead of print]
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  16. Mielke MM, Wiste HJ, Weigand SD, Knopman DS, Lowe VJ, Roberts RO, Geda YE, Swenson-Dravis DM, Boeve BF, Senjem ML, Vemuri P, Petersen RC, Jack CR Jr. Indicators of amyloid burden in a population-based study of cognitively normal elderly. Neurology. 2012 Oct 9; 79(15):1570-7. Epub 2012 Sep 12.
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  17. Mielke MM, Haughey NJ. Could plasma sphingolipids be diagnostic or prognostic biomarkers for Alzheimer's disease? Clin Lipidol. 2012 Oct; 7(5):525-36.
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  18. Oishi K, Mielke MM, Albert M, Lyketsos CG, Mori S. The fornix sign: A potential sign for Alzheimer's disease based on diffusion tensor imaging. J Neuroimaging PMCID PMC3256282. 2012 Oct; 22(4):365-74.
  19. Leoutsakos JM, Han D, Mielke MM, Forrester SN, Tschanz JT, Corcoran CD, Green RC, Norton MC, Welsh-Bohmer KA, Lyketsos CG. Effects of general medical health on Alzheimer's progression: the Cache County Dementia Progression Study. Int Psychogeriatr. 2012 Oct; 24(10):1561-70. Epub 2012 Jun 12.
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  20. *Tighe SK, Oishi K, Mori S, Smith GS, Albert M, Lyketsos CG, Mielke MM. Diffusion tensor imaging of neuropsychiatric symptoms in mild cognitive impairment and Alzheimer’s dementia. J Neuropsychiatry Clin Neurosci PMCID PMC3533244. 2012 Sept; 24(4):484-8.
  21. Mielke MM, Bandaru VV, Haughey NJ, Xia J, Fried LP, Yasar S, Albert M, Varma V, Harris G, Schneider EB, Rabins PV, Bandeen-Roche K, Lyketsos CG, Carlson MC. Serum ceramides increase the risk of Alzheimer disease: the Women's Health and Aging Study II. Neurology. 2012 Aug 14; 79(7):633-41. Epub 2012 Jul 18.
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  22. Rao V, Mielke M, Xu X, Smith GS, McCann UD, Bergey A, Doshi V, Pham DL, Yousem D, Mori S. Diffusion tensor imaging atlas-based analyses in major depression after mild traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2012 Summer; 24(3):309-15.
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  23. Mielke MM, Leoutsakos J-M, Corcoran CD, Green RC, Norton MC, Welsh-Bohmer KA, Tschanz JT, Lyketsos CG. Effects of Food and Drug Administration-approved medications for Alzheimer's disease on clinical progression. Alzheimer's Dement PMCID PMC3341471. 2012 May; 8(3):180-7.
  24. Rosenberg PB, Mielke MM, Appleby BS, Oh ES, Geda YE, Lyketsos CG. The Association of Neuropsychiatric Symptoms in MCI With Incident Dementia and Alzheimer Disease. Am J Geriatr Psychiatry. 2012 Apr 27. [Epub ahead of print]
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  25. Mielke MM, Okonkwo OC, Oishi K, Mori S, Tighe S, Miller MI, Ceritoglu C, Brown T, Albert M, Lyketsos CG. Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer's disease. Alzheimers Dement. 2012; 8(2):105-13.
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  26. Tschanz JT, Corcoran CD, Schwartz S, Treiber K, Green RC, Norton MC, Mielke MM, Piercy K, Steinberg M, Rabins PV, Leoutsakos JM, Welsh-Bohmer KA, Breitner JC, Lyketsos CG. Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County Dementia Progression study. Am J Geriatr Psychiatry. 2011 Jun; 19(6):532-42.
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  27. Rosenberg PB, Mielke MM, Appleby B, Oh E, Leoutsakos J-M, Lyketsos CG. Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction. Int J Geriatr Psychiatr. 2011 Apr; 26(4):364-72.
  28. Okonkwo OC, Mielke MM, Griffith HR, Moghekar AR, O'Brien RJ, Shaw LM, Trojanowski JQ, Albert MS, Alzheimer's Disease Neuroimaging Initiative. Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairment. Arch Neurol. 2011 Jan; 68(1):113-9.
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  29. Mielke MM, Leoutsakos JM, Tschanz JT, Green RC, Tripodis Y, Corcoran CD, Norton MC, Lyketsos CG. Interaction between vascular factors and the APOE epsilon4 allele in predicting rate of progression in Alzheimer's disease. J Alzheimers Dis. 2011; 26(1):127-34.
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  30. Oishi K, Akhter K, Mielke M, Ceritoglu C, Zhang J, Jiang H, Li X, Younes L, Miller MI, van Zijl PC, Albert M, Lyketsos CG, Mori S. Multi-modal MRI analysis with disease-specific spatial filtering: initial testing to predict mild cognitive impairment patients who convert to Alzheimer’s disease. Front Neurol (Aug) Volume 2. 2011; Article 54:1-8.
  31. Yasar S, Ko JY, Nothelle S, Mielke MM, Carlson MC. Evaluation of the effect of systolic blood pressure and pulse pressure on cognitive function: the Women's Health and Aging Study II. PLoS One. 2011; 6(12):e27976. Epub 2011 Dec 09.
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  32. Mielke MM, Haughey NJ, Bandaru VV, Weinberg DD, Darby E, Zaidi N, Pavlik V, Doody RS, Lyketsos CG. Plasma sphingomyelins are associated with cognitive progression in Alzheimer's disease. J Alzheimers Dis. 2011; 27(2):259-69.
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  33. Oishi K, Mielke MM, Albert M, Lyketsos CG, Mori S. DTI analyses and clinical applications in Alzheimer's disease. J Alzheimers Dis. 2011; 26 Suppl 3:287-96.
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  34. Gracia-Garcia P, Rao V, Haughey NJ, Bandaru VVR, Smith G, Rosenberg PB, Lobo A, Lyketsos CG, Mielke MM. Elevated plasma ceramides in depression. J Neuropsychiatr Clin Neurosci. 2011; 23(2):215-8.
  35. Mielke MM, Lyketsos CG. Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets? Neuromolecular Med. 2010 Dec; 12(4):331-40. Epub 2010 Jun 23.
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  36. Rao V, Bertrand M, Rosenberg P, Makley M, Schretlen DJ, Brandt J, Mielke MM. Predictors of new-onset depression after mild traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2010 Winter; 22(1):100-4.
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  37. Mielke MM, Zandi PP, Shao H, Waern M, Ostling S, Guo X, Bjorkelund C, Lissner L, Skoog I, Gustafson DR. The 32-year relationship between cholesterol and dementia from midlife to late life. Neurology. 2010 Nov 23; 75(21):1888-95. Epub 2010 Nov 10.
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  38. Mielke MM, Bandaru VV, McArthur JC, Chu M, Haughey NJ. Disturbance in cerebral spinal fluid sphingolipid content is associated with memory impairment in subjects infected with the human immunodeficiency virus. J Neurovirol. 2010 Nov; 16(6):445-56. Epub 2010 Nov 18.
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  39. Mielke MM, Haughey NJ, Ratnam Bandaru VV, Schech S, Carrick R, Carlson MC, Mori S, Miller MI, Ceritoglu C, Brown T, Albert M, Lyketsos CG. Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss. Alzheimers Dement. 2010 Sep; 6(5):378-85.
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  40. Okonkwo OC, Alosco ML, Griffith HR, Mielke MM, Shaw LM, Trojanowski JQ, Tremont G, Alzheimer's Disease Neuroimaging Initiative. Cerebrospinal fluid abnormalities and rate of decline in everyday function across the dementia spectrum: normal aging, mild cognitive impairment, and Alzheimer disease. Arch Neurol. 2010 Jun; 67(6):688-96.
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  41. Rosenberg PB, Mielke MM, Xue QL, Carlson MC. Depressive symptoms predict incident cognitive impairment in cognitive healthy older women. Am J Geriatr Psychiatry. 2010 Mar; 18(3):204-11.
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  42. Ewers M, Mielke MM, Hampel H. Blood-based biomarkers of microvascular pathology in Alzheimer's disease. Exp Gerontol. 2010 Jan; 45(1):75-9. Epub 2009 Sep 24.
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  43. Mielke MM, Bandaru VV, Haughey NJ, Rabins PV, Lyketsos CG, Carlson MC. Serum sphingomyelins and ceramides are early predictors of memory impairment. Neurobiol Aging. 2010 Jan; 31(1):17-24. Epub 2008 May 05.
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  44. Oh ES, Mielke MM, Rosenberg PB, Jain A, Fedarko NS, Lyketsos CG, Mehta PD. Comparison of conventional ELISA with electrochemiluminescence technology for detection of amyloid-beta in plasma. J Alzheimers Dis. 2010; 21(3):769-73.
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  45. Carlson MC, Erickson KI, Kramer AF, Voss MW, Bolea N, Mielke M, McGill S, Rebok GW, Seeman T, Fried LP. Evidence for neurocognitive plasticity in at-risk older adults: the Experience Corps program. J Gerontol A Biol Sci Med Sci. 2009 Dec; 64(12):1275-82.
  46. Gustafson DR, Bäckman K, Waern M, Östling S, Guo X, Zandi P, Mielke MM, Skoog I. Adiposity indicators and dementia over 32 years in Sweden. Neurology. 2009 Nov 10; 73(19):1559-66.
  47. Mielke MM, Kozauer NA, Chan GKC, George M, Toroney J, Zerrate M, Bandeen-Roche K, Wang M-C, vanZijl P, Pekar JJ, Mori S, Lyketsos CG, Albert M. Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer’s disease. NeuroImage. 2009 May 15; 46(1):47-55.
  48. Rosenberg PB, Mielke MM, Tschanz JT, Cook L, Corcoran C, Hayden KM, Norton M, Rabins PVR, Green RC, Welsh-Bohmer K, Breitner JCS, Munger R, Lyketsos C. Effects of cardiovascular medications on rate of functional decline in Alzheimer’s Disease. Am J Geriatr Psychiatry. 2008 Nov; 16(11):883-92.
  49. Lyketsos CG, Szekely CA, Mielke MM, Rosenberg PB, Zandi PP. Developing new treatments for Alzheimer’s disease: the who, what, when, and how of biomarker guided therapies. Int Psychogeriatr. 2008 Oct; 20(5):871-89.
  50. Mielke MM, Xue Q-L, Zhou J, Chaves PHM, Fried LP, Carlson MC. Baseline serum cholesterol is selectively associated with motor speed and not rates of cognitive decline: the Women’s Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2008 June; 63:619-24.
  51. Rao V, Spiro J, Vaishnavi S, Rastogi P, Mielke M, Noll K, Cornwell E, Schretlen D, Makley M. Prevalence and types of sleep disturbances acutely after traumatic brain injury. Brain Inj. 2008 May; 22(5):381-6.
  52. Kozauer NA, Mielke MM, Chan GKC, Rebok GW, Lyketsos CG. Apolipoprotein E genotype and lifetime cognitive decline. Int Psychogeriatr. 2008 Feb; 20(1):109-23 (Epub 2007 Aug; 21-15).
  53. Mielke MM, Rosenberg P, Tschanz JT, Cook L, Corcoran C, Hayden KM, Norton M, Rabins PVR, Green R, Welsh-Bohmer K, Breitner JCS, Munger R, Lyketsos C. Vascular factors predict rate of progression in Alzheimer’s disease. Neurology. 2007 Nov 6; 69(19):1850-8.
  54. Morgan MD, Mielke MM, O’Brien R, Troncoso JC, Zonderman AB, Lyketsos CG. Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study of Aging (BLSA). Alzheimers Dis Assoc Disord. 2007 July-Sept; 21:199-204.
  55. Jerome GJ, Glass TA, Mielke MM, Xue Q-L, Andersen RE, Fried LP. Physical activity participation by presence and type of functional deficits in older women: The Women’s Health and Aging Studies. J Gerontol A Biol Med Sci. 2006 Nov; 61(11):1171-6.
  56. Mielke MM, Lyketsos CG. Lipids and the pathogenesis of Alzheimer’s disease: is there a link? Int Rev Psychiatry. 2006 Apr; 18(2):173-86.
  57. Sjögren M, Mielke MM, Gustafson D, Zandi P, Skoog I. Cholesterol and Alzheimer’s disease – Is there a relation? Mech Ageing Dev. 2006 Feb; 127(2):138-47.
  58. Rosenberg P, Mielke MM, Samus QM, Rosenblass A, Baker A, Brandt J, Rabins PV, Lyketsos CG. Predictors of nursing home placement in assisted living residents. J Am Directors Med Assoc. 2006 Feb; 7(2):73-8.
  59. Mielke MM, Zandi PP, Blennow K, Gustafson D, Sjögren M, Rosengren L, Skoog I. Low serum potassium in mid-life associated with CSF amyloid-beta (1-42) in late-life. Alzheimers Dis Assoc Disord. 2006 Jan-Mar; 20(1):30-6.
  60. Mielke MM, Zandi PP. Hematological risk factors of vascular disease and their relation to dementia. Dement Geriatr Cogn Disord. 2006; 21(5-6):335-52.
  61. Rosenberg PB, Mielke MM, Lyketsos CG. Caregiver assessment of patients’ depression in Alzheimer disease: longitudinal analysis in a drug treatment study. Am J Geriatr Psychiatry. 2005 Sept; 13(9):822-6.
  62. Mielke MM, Zandi PP, Sjögren M, Gustafson D, Östling S, Steen B, Skoog I. High total cholesterol levels in late-life associated with a reduced risk of dementia. Neurology. 2005 May 24; 64(10):1689-95.
  63. Donny EC, Caggiula AR, Rowell PP, Gharib MA, Maldovan V, Booth S, Mielke MM, Hoffman A, McCallum S. Nicotine self-administration in rats: estrous cycle effects, sex differences and nicotinic receptor binding. Psychopharmacology. 2000 Sept; 151(4):392-405.
  64. Donny EC, Caggiula AR, Rose C, Jacobs KS, Mielke MM, Sved AF. Differential effects of response-contingent and response-independent nicotine in rats. Eur J Pharmacol. 2000 Aug 25; 402(3):231-40.
  65. Donny EC, Caggiula AR, Mielke MM, Booth S, Gharib MA, Maldovan V, Hoffman A, McCallum S. Nicotine self-administration in rats on a progressive ratio schedule of reinforcement. Psychopharmacology. 1999 Nov; 147(2):135-42.
  66. Donny EC, Caggiula AR, Mielke MM, Jacobs KS, Rose C, Sved AF. Acquisition of nicotine self-administration in rats: The effects of dose, feeding schedule and drug contingency. Psychopharmacology. 1998 Mar; 136(1):83-90.


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