Publications - Jun Liu, M.D., Ph.D.

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1. Heckmann BL, Zhang X, Xie X, Liu J. The G0/G1 switch gene 2 (G0S2): regulating metabolism and beyond. Biochim Biophys Acta. 2013 Feb; 1831(2):276-81. Epub 2012 Sep 29.
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2. Yang X, Heckmann BL, Zhang X, Smas CM, Liu J. Distinct mechanisms regulate ATGL-mediated adipocyte lipolysis by lipid droplet coat proteins. Mol Endocrinol. 2013 Jan; 27(1):116-26. Epub 2012 Nov 30.
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3. Heckmann BL, Yang X, Zhang X, Liu J. The autophagic inhibitor 3-methyladenine potently stimulates PKA-dependent lipolysis in adipocytes. Br J Pharmacol. 2013 Jan; 168(1):163-71.
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4. Zeng H, Liu J, Jackson MI, Zhao FQ, Yan L, Combs GF Jr. Fatty liver accompanies an increase in lactobacillus species in the hind gut of C57BL/6 mice fed a high-fat diet. J Nutr. 2013; 143(5):627-31.
5. Langlais P, Dillon JL, Mengos A, Baluch DP, Ardebili R, Miranda DN, Xie X, Heckmann BL, Liu J, Mandarino LJ. Identification of a role for CLASP2 in insulin action. J Biol Chem. 2012 Nov 9; 287(46):39245-53. Epub 2012 Sep 19.
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6. Vachon CM, Scott CG, Fasching PA, Hall P, Tamimi RM, Li J, Stone J, Apicella C, Odefrey F, Gierach GL, Jud SM, Heusinger K, Beckmann MW, Pollan M, Fernandez-Navarro P, Gonzalez-Neira A, Benitez J, van Gils CH, Lokate M, Onland-Moret NC, Peeters PH, Brown Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2012 Jul; 21(7):1156-66. Epub 2012 Mar 27.
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7. Wueest S, Yang X, Liu J, Schoenle EJ, Konrad D. Inverse regulation of basal lipolysis in perigonadal and mesenteric fat depots in mice. Am J Physiol Endocrinol Metab. 2012 Jan 1; 302(1):E153-60. Epub 2011 Oct 11.
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8. Vachon CM, Li J, Scott CG, Hall P, Czene K, Wang X, Liu J, Fredericksen ZS, Rider DN, Wu FF, Olson JE, Cunningham JM, Stevens KN, Sellers TA, Pankratz SV, Couch FJ. No evidence for association of inherited variation in genes involved in mitosis and percent mammographic density. Breast Cancer Res. 2012; 14(1):R7. Epub 2012 Jan 07.
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9. Yang X, Zhang X, Heckmann BL, Lu X, Liu J. Relative contribution of adipose triglyceride lipase and hormone-sensitive lipase to tumor necrosis factor-alpha (TNF-alpha)-induced lipolysis in adipocytes. J Biol Chem. 2011 Nov 25; 286(47):40477-85. Epub 2011 Oct 03.
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10. Stevens KN, Vachon CM, Lee AM, Slager S, Lesnick T, Olswold C, Fasching PA, Miron P, Eccles D, Carpenter JE, Godwin AK, Ambrosone C, Winqvist R, Brauch H, GENICA consortium, Schmidt MK, Cox A, Cross SS, Sawyer E, Hartmann A, Beckmann MW, Schulz-Wendtland Common breast cancer susceptibility loci are associated with triple-negative breast cancer. Cancer Res. 2011 Oct 1; 71(19):6240-9. Epub 2011 Aug 15.
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11. Wang H, Bell M, Sreenevasan U, Hu H, Liu J, Dalen K, Londos C, Yamaguchi T, Rizzo MA, Coleman R, Gong D, Brasaemle D, Sztalryd C. Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein. J Biol Chem. 2011 May 6; 286(18):15707-15. Epub 2011 Mar 09.
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12. Lu X, Yang X, Liu J. Differential control of ATGL-mediated lipid droplet degradation by CGI-58 and G0S2. Cell Cycle. 2010 Jul 15; 9(14):2719-25. Epub 2010 Jul 27.
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13. Yang X, Lu X, Liu J. Identification of a novel splicing isoform of murine CGI-58. FEBS Lett. 2010 Mar 5; 584(5):903-10. Epub 2010 Jan 18.
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14. Yang X, Lu X, Lombes M, Rha GB, Chi YI, Guerin TM, Smart EJ, Liu J. The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab. 2010 Mar 3; 11(3):194-205.
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15. White J, Guerin T, Swanson H, Post S, Zhu H, Gong M, Liu J, Everson WV, Li XA, Graf GA, Ballard HO, Ross SA, Smart EJ. Diabetic HDL-associated myristic acid inhibits acetylcholine-induced nitric oxide generation by preventing the association of endothelial nitric oxide synthase with calmodulin. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C295-305. Epub 2007 Oct 31.
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16. Zhang M, Liu J, Cheng A, Deyoung SM, Saltiel AR. Identification of CAP as a costameric protein that interacts with filamin C. Mol Biol Cell. 2007 Dec; 18(12):4731-40. Epub 2007 Sep 26.
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17. Zhang M, Liu J, Cheng A, Deyoung SM, Chen X, Dold LH, Saltiel AR. CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility. EMBO J. 2006 Nov 15; 25(22):5284-93. Epub 2006 Nov 02.
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18. Liu J, DeYoung SM, Zhang M, Zhang M, Cheng A, Saltiel AR. Changes in integrin expression during adipocyte differentiation. Cell Metab. 2005 Sep; 2(3):165-77.
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19. Liu J, Deyoung SM, Zhang M, Dold LH, Saltiel AR. The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes. J Biol Chem. 2005 Apr 22; 280(16):16125-34. Epub 2005 Feb 14.
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20. Hu J, Liu J, Ghirlando R, Saltiel AR, Hubbard SR. Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol Cell. 2003 Dec; 12(6):1379-89.
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21. Liu J, DeYoung SM, Hwang JB, O'Leary EE, Saltiel AR. The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport. J Biol Chem. 2003 Sep 19; 278(38):36754-62. Epub 2003 Jul 02.
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22. Liu J, Kimura A, Baumann CA, Saltiel AR. APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. Mol Cell Biol. 2002 Jun; 22(11):3599-609.
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23. Liu J, Prickett TD, Elliott E, Meroni G, Brautigan DL. Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4. Proc Natl Acad Sci U S A. 2001 Jun 5; 98(12):6650-5. Epub 2001 May 22.
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24. Liu J, Brautigan DL. Glycogen synthase association with the striated muscle glycogen-targeting subunit of protein phosphatase-1. Synthase activation involves scaffolding regulated by beta-adrenergic signaling. J Biol Chem. 2000 Aug 25; 275(34):26074-81.
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25. Liu J, Brautigan DL. Insulin-stimulated phosphorylation of the protein phosphatase-1 striated muscle glycogen-targeting subunit and activation of glycogen synthase. J Biol Chem. 2000 May 26; 275(21):15940-7.
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26. Liu J, Wu J, Oliver C, Shenolikar S, Brautigan DL. Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit. Biochem J. 2000 Feb 15; 346 Pt 1:77-82.
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27. Jewell JE, Orwick J, Liu J, Miller KW. Functional importance and local environments of the cysteines in the tetracycline resistance protein encoded by plasmid pBR322. J Bacteriol. 1999; 181(5):1689-93.
28. Wu J, Liu J, Thompson I, Oliver CJ, Shenolikar S, Brautigan DL. A conserved domain for glycogen binding in protein phosphatase-1 targeting subunits. FEBS Lett. 1998 Nov 13; 439(1-2):185-91.
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29. Guo D, Liu J, Motlagh A, Jewell J, Miller KW. Efficient insertion of odd-numbered transmembrane segments of the tetracycline resistance protein reuires even-numbered segments. J Biol Chem. 1996; 271(48):30829-34.