Dr. Rae's laboratory is interested in ion transport mechanisms in lens, cornea, and ciliary body of the eye with special emphasis on ion channel proteins. These transport proteins are studied by patch voltage clamp techniques, molecular biology procedures, image analysis, and ratio imaging fluorescence microscopy. The goals of the laboratory are to identify and characterize at a molecular level the transporters that are involved in disease processes in ocular tissues and to understand how the transporters are regulated.