David I. Smith, Ph.D.
The laboratory of David I. Smith, Ph.D., uses the most cutting-edge genomic technologies to better understand the molecular alterations that underlie cancer development.
Dr. Smith is also the chairman of the Technology Assessment Committee, which works for the Center for Individualized Medicine at Mayo Clinic. The goal of this committee is to evaluate new technologies that could have a significant impact on research and its clinical translation. Perhaps the most exciting technology has been the recent advancements in DNA sequencing, which now make it possible to completely sequence a person's entire genome for just a few thousand dollars.
There are two major projects ongoing in Dr. Smith's laboratory:
Significance to patient care
The newest sequencing technologies will soon offer an ability to better understand the precise alterations that occur in a specific cancer, and this will lead to tailored therapies more ideal for each patient. Currently, Dr. Smith's laboratory is focusing on head and neck cancer, and how sequencing will better inform clinicians as to which cancers are more aggressive versus less aggressive. The laboratory is also looking for molecular markers that would help to determine which drugs would be more effective on a specific cancer.
Postdoctoral Fellow. Advisor: Dr. John Wasmuth
National Institutes of Health Senior Postdoctoral Fellowship
Advisor: Dr. David Shafritz
Biochemistry. Research Advisor: Dr. Julian Davies. Thesis Title: Purification and characterization of aminoglycoside phosphotransferases
Majors: Mathematics and Molecular Biology
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