Stephen N. Thibodeau, Ph.D.
Stephen N. Thibodeau, Ph.D., is a professor of laboratory medicine and pathology in the College of Medicine, Mayo Clinic, and a co-director of the Molecular Genetics Laboratory, a clinical laboratory in the Department of Laboratory Medicine and Pathology. In addition, he is a member of the Division of Medical Genetics.
The main focus of Dr. Thibodeau's laboratory research is to understand the genetics of both prostate cancer and colon cancer. He and his colleagues want to answer the question: Why is it that some families have more cancers among family members when compared to other families?
Historically, in order to look for genes involved in hereditary cancer, Dr. Thibodeau and his team would examine the involvement of one gene at a time among the families under study. New DNA sequencing technologies, however, continue to evolve at such an extremely rapid rate that it's now possible to easily sequence all of the known genes simultaneously.
Over the last several years, Dr. Thibodeau's laboratory has explored the use of next-generation sequencing technologies for the discovery of genetic susceptibility genes for both hereditary prostate cancer and hereditary colon cancer.
Significance to patient care
Dr. Thibodeau's program has been committed to translational research — that is, work that can be implemented in a clinical laboratory setting for routine patient care.
As Dr. Thibodeau co-directs the clinical Molecular Genetics Laboratory in addition to overseeing his research laboratory, he and his team have been able to take advantage of the work performed in the research laboratory to develop and implement a variety of tests in the Molecular Genetics Laboratory that can be used directly for patient care.
As an example, new technologies in DNA sequencing mentioned are now beginning to be incorporated in routine clinical practice at Mayo Clinic. In addition, there are a number of clinical assays that are routinely used for the diagnosis of hereditary colon cancer.
Biochemistry. Dissertation: Analysis of the Molecular Events Leading to Protein Secretion. Advisor: Kenneth A. Walsh
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