Kidney Development and Cyst Formation - Caroline R. Sussman

Overview

The kidney is composed of several cell types, which are organized into a complex network of tissues for processing the blood and regulating the final composition of urine. Many processes involved in kidney development are also required for proper kidney maintenance and function.

Dr. Sussman's laboratory focuses on pathogenic alterations in kidney development and maintenance leading to cyst formation and polycystic kidney disease (PKD). PKD is primarily characterized by progressive renal cyst formation, ultimately leading to renal failure. It occurs in two major forms: autosomal dominant (ADPKD) and autosomal recessive (ARPKD).

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