Ongoing Research

Anthrax ~

Anthrax Vaccine Adsorbed (AVA): Human Reactogenicity and Immunogenicity Trial to Address Change in Route of Administration and Dose Reduction (CDC)

• The major objective of this study is to determine the safety and effectiveness of AVA through a change in route of administration and a reduction in dose.

Measles ~

Immunogenetics of Measles Immunity (NIH R01)

• The major goal of this study is to examine the lymphoproliferative and cytokine profile response to measles virus vaccine and the immune response following two doses of measles immunization in human subjects.

Rubella ~

Immunogenetic Mechanisms of Rubella Vaccine Response (NIH R01)

• The major, long-term objective of this research study is to determine the genetic mechanisms that influence the immune response (antibody level and lymphoproliferative responses) to viral vaccines. We are using the live viral vaccine, rubella, as a model. We will also determine whether these findings are specific to rubella or generalizable to concomitantly administered live viral (measles and mumps) vaccines.

Smallpox ~

Population Genetics Analysis Program: Immunity to Vaccines/Infections (NIH N01)

• The broad objective of this study is to examine the role of candidate human immune response gene polymorphisms (and their receptors, expression and function) in inter-individual variability in vaccinia vaccine-induced humoral and cell-mediated immune responses among a cohort of 1,000 recently vaccinated subjects.