Amir Lerman, M.D.

Coronary physiology and the role of the endothelium in regulating coronary vascular tone.

Most of my research is divided into three main lines:

1. Clinical studies in the Cardiac Cathetherization Laboratory focus on patients with early coronary atherosclerosis and endothelial dysfunction. We use state-of-the-art technology, including intracoronary Doppler, intracoronary pressure assessment and intravascular ultrasound. The Center for Coronary Physiology exists within the Cardiac Catheterization Laboratory for collecting and analyzing data.
2. Animal studies focus on the role of the endothelium and endothelial-derived factors with emphasis on endothelin and nitric oxide as modulators of coronary vascular tone.
3. In vitro studies include large and micro vessels organ bath, immunohistochemical studies for in-depth investigation of the role of the endothelium in cardiovascular diseases.